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Receptor/Ligand Sorting Along the Endocytic Pathway

  • Book
  • © 1989

Overview

Authors:
  1. Jennifer J. Linderman

    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, USA

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  2. Douglas A. Lauffenburger

    1. Department of Chemical Engineering, University of Pennsylvania, Philadelphia, USA

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    You can also search for this author in PubMed   Google Scholar

Part of the book series: Lecture Notes in Biomathematics (LNBM, volume 78)

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Table of contents (7 chapters)

  1. Front Matter

    Pages I-VI
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  2. Introduction and Overview

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 1-2

  3. Receptor — Mediated Endocytosis and Receptor/Ligand Sorting

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 3-17

  4. An Equilibrium Model of the Sorting Process

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 18-21

  5. Simple Kinetic Models of Sorting

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 22-55

  6. A Whole Cell Kinetic Model of the Endocytic Cycle: Focus on Sorting

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 56-79

  7. A Kinetic Model of Sorting that Predicts Ligand Effects

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 80-129

  8. Conclusions

    • Jennifer J. Linderman, Douglas A. Lauffenburger
    Pages 130-133

  9. Back Matter

    Pages 134-166
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Keywords

About this book

This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.

Authors and Affiliations

  • Department of Chemical Engineering, University of Michigan, Ann Arbor, USA

    Jennifer J. Linderman

  • Department of Chemical Engineering, University of Pennsylvania, Philadelphia, USA

    Douglas A. Lauffenburger

Bibliographic Information

  • Book Title: Receptor/Ligand Sorting Along the Endocytic Pathway

  • Authors: Jennifer J. Linderman, Douglas A. Lauffenburger

  • Series Title: Lecture Notes in Biomathematics

  • DOI: https://doi.org/10.1007/978-3-642-48892-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1989

  • Softcover ISBN: 978-3-540-50849-6Published: 22 February 1989

  • eBook ISBN: 978-3-642-48892-4Published: 08 March 2013

  • Series ISSN: 0341-633X

  • Series E-ISSN: 2196-9981

  • Edition Number: 1

  • Number of Pages: VI, 164

  • Topics: Applications of Mathematics, Algebra, Mathematical and Computational Biology

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