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Killer Cell Inhibitory Receptor Expression by T Cells

  • Chapter
Specificity, Function, and Development of NK Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 230))

Abstract

The killer cell inhibitory receptors (KIR) are a family of immunoglobulin (Ig)-like cell surface receptors which are differentially expressed by cytotoxic lymphocyte populations and recognize subsets of human leukocyte antigen (HLA) class I molecules on potential target cells (Long et al. 1996). Originally identified as inhibitory receptors of natural killer (NK) cells having discrete specificities for HLA class I allotypes, KIR are also expressed by a small but significant population of T cells (Ferrini et al. 1994; Mingari et al. 1995; Phillips et al. 1995). Importantly, KIR recognition of their complementary class I ligands can modulate T cell function in a manner comparable to that observed for NK cells. This contribution summarizes recent advances in understanding the functional significance of T cell expression of KIR family members.

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Authors and Affiliations

  1. Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA, 94304, USA

    A. D’Andrea & L. L. Lanier

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  1. A. D’Andrea
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  2. L. L. Lanier
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Editors and Affiliations

  1. Karolinska Institute, Microbiology and Tumor Biology Center, S-17177, Stockholm, Sweden

    Klas Kärre

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Marco Colonna M.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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D’Andrea, A., Lanier, L.L. (1998). Killer Cell Inhibitory Receptor Expression by T Cells. In: Kärre, K., Colonna, M. (eds) Specificity, Function, and Development of NK Cells. Current Topics in Microbiology and Immunology, vol 230. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46859-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-46859-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-46859-9

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