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The Use of Ribozymes in Gene Therapy Approaches to AIDS

  • Conference paper
Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 144))

Abstract

The development of effective therapies or promising vaccines for AIDS has been a goal of international research for more than a decade but the mutability of the virus and complex pathogenesis of the disease have made these goals extremely elusive. Only recently have traditional chemotherapeutic approaches begun to look promising. As an alternative, a number of groups have been investigating the potential of antiviral RNAs expressed from recombinant viral vectors to form the basis of a gene therapy for the disease. In this paper, I outline several challenges to the efficient deployment of a gene therapy for AIDS, particularly the efficient transduction of heamopoietic cells and their engraftment in a physiologically competent form, and review the current approaches designed to overcome them.

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Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK

    W. James

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  1. W. James
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© 1998 Springer-Verlag Berlin · Heidelberg

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James, W. (1998). The Use of Ribozymes in Gene Therapy Approaches to AIDS. In: Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy. Recent Results in Cancer Research, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46836-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-46836-0_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46838-4

  • Online ISBN: 978-3-642-46836-0

  • eBook Packages: Springer Book Archive

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