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Construction of Immunogenic Tumor Cell Surfaces by Somatic Gene Transfer

  • Conference paper
Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 144))

Abstract

A contemporary model of T-lymphocyte activation (two-signal hypothesis) strongly suggests that in addition to recognition of peptide/MHC and, thus, tumor antigens by the T-cell antigen receptor, costimulatory signals are required for optimal T-cell clonal expansion and their differentiation into effector cells (Mueller et al. 1989; Schwartz 1990). Receptors for costimulatory signals have been identified and defined, among which CD 2, CD 11/18, CD 28, CD 4, and CD 8 appear to play important roles. Their respective ligands/coreceptors are CD 58, CD 54, CD 80/CD 86, MHC II, and MHC I, respectively.

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Authors and Affiliations

  1. Institute for Immunology, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany

    S. C. Meuer

  2. University Women’s Hospital, Vossstrasse 7, 69115, Heidelberg, Germany

    B. Gückel

  3. German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    M. Lindauer & U. Moebius

Authors
  1. S. C. Meuer
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  2. B. Gückel
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  3. M. Lindauer
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  4. W. Rudy
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  5. U. Moebius
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© 1998 Springer-Verlag Berlin · Heidelberg

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Meuer, S.C., Gückel, B., Lindauer, M., Rudy, W., Moebius, U. (1998). Construction of Immunogenic Tumor Cell Surfaces by Somatic Gene Transfer. In: Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy. Recent Results in Cancer Research, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46836-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-46836-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46838-4

  • Online ISBN: 978-3-642-46836-0

  • eBook Packages: Springer Book Archive

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