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Monamine Oxidase

  • Chapter
Catecholamines I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 90 / 1))

Abstract

The enzyme monoamine oxidase (amine: oxygen oxidoreductase (deaminating) EC 1.4.3.4.) (MAO) catalyses the oxidative deamination of amines according to the overall reaction:

$$RC{{H}_{2}}N{{H}_{2}}+{{O}_{2}}+{{H}_{2}}O\to RCHO+N{{H}_{3}}+{{H}_{2}}{{O}_{2}}$$

It is present in the central nervous system as well as in peripheral tissues, and it functions in the breakdown of neurotransmitter and hormonal amines as well as those aristing from the diet or from bacterial action. The history of its discovery and the earlier work on its properties have been described in detail (see e.g., Blaschko 1952, 1963; Tipton 1975; Youdim 1975, Kinemuchi et al. 1987) and this review will concentrate on the knowledge gained from more recent studies.

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  1. M. B. H. Youdim
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  2. J. P. M. Finberg
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  3. K. F. Tipton
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-8700, Würzburg, Germany

    U. Trendelenburg (Professor Dr.) (Professor Dr.)

  2. Department of Pharmacology, Colorado University, Medical Center, 4200 East Ninth Street, 802 62, Denver, CO, USA

    N. Weiner (Professor Dr.) (Professor Dr.)

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Youdim, M.B.H., Finberg, J.P.M., Tipton, K.F. (1988). Monamine Oxidase. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines I. Handbook of Experimental Pharmacology, vol 90 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46625-0_3

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