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The Enterohepatic Circulation

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Concepts in Biochemical Pharmacology

Abstract

Substances are said to undergo an enterohepatic circulation (EHC) when they are excreted into the bile, pass into the lumen of the intestine, are reabsorbed and then return to the liver via the circulation. Many endogenous and exogenous substances can undergo an EHC. Among the endogenous substances are the bile salts, the biliary lipids and biliary phospholipids; the degree of reabsorbability varies considerably for each of these types of substances. Other endogenous substances include estrone and estriol (Sandberg et al., 1967), folic acid (Baker et al., 1965; Herbert, 1965), vitamin B12 (Grasbeck et al., 1958), and urobilinogen (Lester et al., 1965). Ibrahim and Watson (1968) demonstrated that an EHC exists for protoporphyrin in man. The oral administration of cholestyramine, an anionic exchange resin, improves the clinical condition of patients suffering from porphyria cutanea tarda (Stathers, 1966) or from erythropoietic protoporphyria (Lischner, 1966) apparently by interrupting the EHC for the porphyrins.

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  1. G. L. Plaa
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Plaa, G.L. (1975). The Enterohepatic Circulation. In: Gillette, J.R., Mitchell, J.R. (eds) Concepts in Biochemical Pharmacology. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 28 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46314-3_5

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