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The Incorporation of 5-Fluorouracil Into RNA and its Molecular Consequences

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Progress in Molecular and Subcellular Biology

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 1))

Abstract

It was recognized about two decades ago that analogs of nucleic acid bases could be utilized as substrates for incorporation into polynucleotides, resulting in the formation of “fraudulent” nucleic acids containing an aberrant base. Among the compounds most extensively studied which are able to replace a base in nucleic acids are 8-azaguanine, 2-thiouracil, 5-bromouracil, 5-fluorouracil, 6-azathymine and 6-thioguanine. The total number of analogs which are incorporated into polynucleotides is quite limited. A general review on metabolite analog incorporation appeared in 1958 (Matthews, 1958) which described the functions associated with the presence of such an abnormal base in nucleic acids. Because most of the analogs had carcinostatic activity, the anabolism and catabolism of such compounds in relation to their biochemical and chemotherapeutic actions was the subject of another review (Mandel, 1959).

This review was supported in part by USPHS Grant CA 02978 from the National Cancer Institute, N.I.H., Bethesda, Maryland.

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  1. H. George Mandel
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  1. Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C., USA

    Fred E. Hahn (Chief) (Chief)

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Mandel, H.G. (1969). The Incorporation of 5-Fluorouracil Into RNA and its Molecular Consequences. In: Hahn, F.E. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46200-9_4

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