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Arrestins in Host–Pathogen Interactions

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Arrestins - Pharmacology and Therapeutic Potential

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 219))

Abstract

In the context of host–pathogen interaction, host cell receptors and signaling pathways are essential for both invading pathogens, which exploit them for their own profit, and the defending organism, which activates early mechanism of defense, known as innate immunity, to block the aggression. Because of their central role as scaffolding proteins downstream of activated receptors, β-arrestins are involved in multiple signaling pathways activated in host cells by pathogens. Some of these pathways participate in the innate immunity and the inflammatory response. Other β-arrestin-dependent pathways are actually hijacked by microbes and toxins to penetrate into host cells and spread in the organism.

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Authors and Affiliations

  1. Inserm, U1016, Institut Cochin, Paris, France

    Stefano Marullo

  2. CNRS, UMR8104, Paris, France

    Stefano Marullo

  3. Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Stefano Marullo & Mathieu Coureuil

  4. Inserm, U1002, Unité de Pathogénie des Infections Systémiques, Paris, France

    Mathieu Coureuil

Authors
  1. Stefano Marullo
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  2. Mathieu Coureuil
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Correspondence to Stefano Marullo .

Editor information

Editors and Affiliations

  1. Professor of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Vsevolod V. Gurevich

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Marullo, S., Coureuil, M. (2014). Arrestins in Host–Pathogen Interactions. In: Gurevich, V. (eds) Arrestins - Pharmacology and Therapeutic Potential. Handbook of Experimental Pharmacology, vol 219. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41199-1_18

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