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Anti-Inflammatory and Anticancer Drugs from Nature

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Advances in Nutrition and Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 159))

Abstract

Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to reduce tumor growth. The recent discovery of new natural products has been accelerated by novel technologies (high throughput screening of natural products in plants, animals, marine organisms, and microorganisms). Vincristine, irinotecan, etoposide, and paclitaxel are examples of compounds derived from plants that are used in cancer treatment. Similarly, actinomycin D, mitomycin C, bleomycin, doxorubicin, and L-asparaginase are drugs derived from microorganisms. In this review, we describe the molecular mechanisms of natural compounds with anti-inflammatory and anticancer activities.

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Abbreviations

VEGF:

Vascular endothelial growth factor

ROS:

Reactive oxygen species

NF-κB:

Transcription factor nuclear factor κB

N-pyrazinecarbonyl-L-phenyl-alanine-l-leucine boronic acid:

Bortezomib

BAFF:

B-cell activating factor

NIK:

NF-κB-inducing kinase

STAT:

Signal transducer and activator of transcription

COX-2:

Cyclooxygenase-2

CDK:

Cyclin-dependent kinase

EEF2:

Eukaryotic elongation factor 2

PKC:

Protein kinase C

PI3K:

Phosphoinositide 3-kinase

MAPK:

Mitogen-activated protein kinase

MLCK:

Myosin light-chain kinase

ATM:

Ataxia telangiectasia mutated

PAL:

Phenylalanine ammonia-lyase

EGCG:

Epigallocatechin gallate

IKK:

Inhibits IκB kinase

DHA:

Docosahexaenoic acid

EPA:

Eicosapentaenoic acid

ETA:

11,14,17-eicosatrienoic acid

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Acknowledgments

BO and NL are recipients of doctoral Télévie-Luxembourg grants. Research at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer is supported by “Recherche Cancer et Sang” foundation, “Recherches Scientifiques Luxembourg” association, “Een Haerz fir kriibskrank Kanner” association, the Action Lions “Vaincre le Cancer” association and Télévie Luxembourg. Further support was received from the European Union (ITN “RedCat” 215009, Interreg IVa project “Corena”).

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Authors and Affiliations

  1. Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540, Luxembourg, Luxembourg

    Barbora Orlikova, Noémie Legrand, Jana Panning, Mario Dicato & Marc Diederich

  2. College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea

    Marc Diederich

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  1. Barbora Orlikova
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  2. Noémie Legrand
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  3. Jana Panning
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  4. Mario Dicato
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  5. Marc Diederich
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Correspondence to Marc Diederich .

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Editors and Affiliations

  1. Dept. of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

    Vincenzo Zappia

  2. Clinical and Experimental Medicine, University of Naples "Federico II", Naples, Italy

    Salvatore Panico

  3. Institute of Food Sciences National Research Council, Avellino, Italy

    Gian Luigi Russo

  4. Dept. of Experimental Oncology, National Cancer Institute, Naples, Italy

    Alfredo Budillon

  5. Dept. of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

    Fulvio Della Ragione

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Orlikova, B., Legrand, N., Panning, J., Dicato, M., Diederich, M. (2014). Anti-Inflammatory and Anticancer Drugs from Nature. In: Zappia, V., Panico, S., Russo, G., Budillon, A., Della Ragione, F. (eds) Advances in Nutrition and Cancer. Cancer Treatment and Research, vol 159. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38007-5_8

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