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Giant-Cell Tumour of Bone (GCT)

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European Surgical Orthopaedics and Traumatology

Abstract

Giant-cell tumour of the bone (GCT) is an aggressive, benign lesion with a high rate of local recurrence. Ten percent undergo malignant transformation and 1–4 % give pulmonary metastases even when the histological appearance is benign. Local oncological control (recurrence rate of 0–5 %) is best achieved by en bloc resection of the GCT with normal tissue, which means sacrificing the joint in most cases because of the epiphyseal location of the tumour. Curettage of the defect is therefore the initial treatment of choice. The high rate of recurrence of 20–50 % can be decreased by using different adjuvants such as phenol, bone cement or liquid nitrogen, etc. The indications for curettage and resection are discussed and the various possibilities for reconstruction of the defects in different sites are described. Disease-free survival can be achieved in 96–100 % by adequate treatment.

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Authors and Affiliations

  1. Department of Orthopaedics, Semmelweis University, H-1113 Budapest, Karolina út 27, Budapest, Hungary

    Miklós Szendrői

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  1. Miklós Szendrői
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Correspondence to Miklós Szendrői .

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  1. Royal National Orthopaedic Hospital, Stanmore, United Kingdom

    George Bentley

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Szendrői, M. (2014). Giant-Cell Tumour of Bone (GCT). In: Bentley, G. (eds) European Surgical Orthopaedics and Traumatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34746-7_186

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  • DOI: https://doi.org/10.1007/978-3-642-34746-7_186

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-34745-0

  • Online ISBN: 978-3-642-34746-7

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