Abstract
Spiders from four families [Atrax and Hadronyche (Hexathelidae), Loxosceles (Sicariidae), Latrodectus (Theridiidae) and Phoneutria (Ctenidae), with several species each] may cause severe symptoms when biting humans. This is mainly due to a combination of factors: (1) synanthropic way of living (all taxa), (2) high densities in urban areas (Latrodectus, Loxosceles, Phoneutria), (3) large body size (Atrax, Hadronyche, Phoneutria), (4) ion-channel targeting neuropeptides or other venom compounds which are very potent and/or to which vertebrates/humans are very sensitive (Atrax, Hadronyche, Latrodectus, Phoneutria), (5) a venom enzyme causing necrosis (Loxosceles) and (6) aggressive behaviour towards humans (Phoneutria). For each spider genus, envenomation symptoms, therapy, venom peculiarity and frequency of bites are described in detail. Several decades ago, fatal issues were reported for all four groups, but medical documentation as well as medical standards in many countries was poor. In the last 2–3 decades, no fatalities were reported for Atrax, Hadronyche, Latrodectus and Phoneutria. The situation with Loxosceles is less clear, but on a global scale, it is obvious that fatalities due to spider bites are now close to zero, which refers to an annual mortality of <0.001 per million humans. Thus, spiders are by far less dangerous than bees and wasps.
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References
American Association of Poison Control Centers (2012) National Poison Data System. Available at www.aapc.org
Binford G (2013) The evolution of a toxic enzyme in sicariid spiders. In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg (this volume)
Bucaretchi F, Deus Reinaldo CR, Hyslop S, Madureira PR, De Capitani EM, Vieira RJ (2000) A clinico-epidemiological study of bites by spiders of the genus Phoneutria. Rev Inst Med Trop Sao Paulo 42:17–21
Chippaux J-P (1998) Snake-bites: appraisal of the global situation. Bull World Health Organ 76:515–524
Chippaux J-P, Goyffon M (2008) Epidemiology of scorpionism: a global appraisal. Acta Trop 107:71–79
Gaisford K, Kautz DD (2011) Black widow spider: a case study. Dimens Crit Care Nurs 30:79–86
Herzig V, King G (2013) The neurotoxic mode of action of venoms from the spider family Theraphosidae. In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg (this volume)
Hoxha R (2006) Two Albanians die from black widow spider bites. BMJ 333:278
Isbister GK, Gray MR (2002a) A prospective study of definite spider bites, with expert spider identification. Q J Med 95:723–731
Isbister GK, Gray MR (2002b) Bites by Australian mygalomorph spiders (Araneae, Mygalomorphae), including funnel-web spiders (Atracinae) and mouse spiders (Actinopodidae: Missulena spp.). Toxicon 43:133–140
Isbister GK, Gray MR (2003) Latrodectism: a prospective cohort study of bites by formally identified redback spiders. Med J Aust 179:88–91
Isbister GK, White J (2004) Clinical consequences of spider bites: recent advances in our understanding. Toxicon 43:477–492
Isbister GK, Gray MR, Balit CR, Raven RJ, Stokes BJ, Porges K, Tankel AS, Turner E, White J, Fisher MMD (2005) Funnel-web spider bites: a systematic review of recorded clinical cases. Med J Aust 182:407–411
Kuhn-Nentwig L, Stöcklin R, Nentwig W (2011) Venom composition and strategies in spiders: is everything possible? Adv Insect Physiol 60:1–86
Langley RL (2005) Animal-related fatalities in the United States – an update. Wilderness Environ Med 16:67–74
Lucas SM, Da Silva PJ, Bertani R, Costa Cardoso JL (1994) Mygalomorph spider bites: a report on 91 cases in the State of Sao Paulo, Brazil. Toxicon 32:1211–1215
McGain F, Harrison J, Winkel KD (2000) Wasp sting mortality in Australia. Med J Aust 173:198–200
Nicholson GM, Little MJ, Birinyi-Strachan LC (2004) Structure and function of δ-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel. Toxicon 43:587–599
Peterson ME (2006) Black widow envenomation. Clin Tech Small Anim Pract 21:187–190
Russell FE (1991) Venomous arthropods. Vet Hum Toxicol 33:505–508
Sams HH, Dunnick CA, Smith ML, King LE (2001) Necrotic arachnidism. J Am Acad Dermatol 44:561–573
Suter RB, Stratton GE (2013) Predation by spitting spiders—elaborate venom gland, intricate delivery system. In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg (this volume)
Vetter RS (2008) Spiders of the genus Loxosceles (Araneae, Sicariidae): a review of biological, medical and psychological aspects regarding envenomation. J Arachnol 36:150–163
Vetter RS (2012) Envenomation by spiders of the genus Hololena (Araneae: Agelenidae). Toxicon 60:312–314
Vetter RS, Isbister GK (2008) Medical aspects of spider bites. Annu Rev Entomol 53:409–429
Vetter RS, Isbister GK, Bush SP, Boutin LJ (2006) Verified bites by yellow sac spiders (genus Cheiracanthium) in the United States and in Australia: where is the necrosis? Am J Trop Med Hyg 74:1043–1048
White J, Cardoso JL, Fan HW (1995) Clinical toxicology of spider bites. In: Meier J, White J (eds) Clinical toxicology of animal venom and poisons. CRC, Boca Raton
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Nentwig, W., Kuhn-Nentwig, L. (2013). Spider Venoms Potentially Lethal to Humans. In: Nentwig, W. (eds) Spider Ecophysiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33989-9_19
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DOI: https://doi.org/10.1007/978-3-642-33989-9_19
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