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Malignant Melanoma

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Neutron Capture Therapy

Abstract

In 1972, an experimental study on boron neutron capture therapy (BNCT) for malignant melanoma was initiated by Mishima and his colleagues. They first proposed employing BNCT for malignant melanomas, utilizing the specific melanin synthesis activity of melanoma cells. For that purpose, 10B-para-boronophenylalanine (BPA) was reevaluated by his group (Kobe University group). Clinical investigations of BNCT for melanoma were started for patients with cutaneous melanomas using BPA and a thermal neutron beam and using an epithermal beam to treat patients with brain metastases of malignant melanoma. Five groups have carried out BNCT of melanoma in the world: at the Massachusetts Institute of Technology (MIT) for cutaneous melanoma and for intracerebral melanoma (Harvard/MIT group), at the high flux reactor in Petten for brain metastases of melanoma (Petten/Essen group), at RA-6 reactor in Argentina for cutaneous melanoma (Argentina group), and at KUR and JRR-4 in Japan for mucosal melanomas of the head and neck. The local responses and survival of patients with cutaneous and mucosal malignant melanomas treated with BNCT are summarized in this chapter.

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Authors and Affiliations

  1. Department of Radiation Oncology, Kawasaki Medical School, Okayama, 701-0192, Japan

    Junichi Hiratsuka

  2. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan

    Hiroshi Fukuda

Authors
  1. Junichi Hiratsuka
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  2. Hiroshi Fukuda
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Correspondence to Junichi Hiratsuka .

Editor information

Editors and Affiliations

  1. Zentrum für Konservative Onkologie, Klinik für Strahlentherapie, Univ.Klinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    Wolfgang Sauerwein

  2. Philipps-University Marburg, Department of Radiation Oncology, University Hospital Marburg,, Baldingerstrasse 1, Marburg, 35043, Germany

    Andrea Wittig

  3. Joint Research Centre, Institute for Engergy, European Commission, Westerduinweg 3, LE Petten, 1755, Netherlands

    Raymond Moss

  4. , Department of Neurosurgery, Kagawa National Children's Hospital, Zentsuji-cho 2603, Zentsuji, 765-8501, Kagawa, Japan

    Yoshinobu Nakagawa

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© 2012 Springer-Verlag Berlin Heidelberg

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Hiratsuka, J., Fukuda, H. (2012). Malignant Melanoma. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_26

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  • DOI: https://doi.org/10.1007/978-3-642-31334-9_26

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31333-2

  • Online ISBN: 978-3-642-31334-9

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