Abstract
Gender accounts for important differences in the incidence, prevalence, and course of many immunoinflammatory diseases. However, similar treatment strategies, such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor-α (TNF-α) inhibitors, have been advocated for both genders. Experimental studies found that molecular mechanisms of inflammation differ in males and females. In our chapter we summarize the data concerning gender-specific aspects about prevalence of use, drug survival, responsiveness, and adverse drug effects of NSAIDs and TNF-α inhibitors. Gender-related differences in the prevalence and course of many autoimmune diseases as well as differences in effects of anti-inflammatory drugs should be considered for the tailored treatment options for these patients.
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Abbreviations
- COX:
-
Cyclooxygenase
- ERK:
-
Extracellular signal-regulated kinase
- FDA:
-
Food and Drug Administration
- IFN:
-
Interferon
- IL:
-
Interleukin
- IL-1Ra:
-
IL-1 receptor antagonist
- NF-κB:
-
Nuclear factor-κB
- NSAIDs:
-
Nonsteroidal anti-inflammatory drugs
- RA:
-
Rheumatoid arthritis
- TNF-α:
-
Tumor necrosis factor-α
- UGIB:
-
Upper gastrointestinal bleeding
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Demyanets, S., Wojta, J. (2013). Sex Differences in Effects and Use of Anti-inflammatory Drugs. In: Regitz-Zagrosek, V. (eds) Sex and Gender Differences in Pharmacology. Handbook of Experimental Pharmacology, vol 214. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30726-3_20
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