Abstract
Immunoglobulin (Ig) preparations are widely used as adjunctive sepsis therapies. The rationale for this treatment concept is the hypothesis that low endogenous serum levels of IgG, IgM or IgA may dispose to severe infection and sepsis, and that substitution with the respective immunoglobulins — either one of the many intravenous IgG preparations or the intravenous IgGMA preparation, Pentaglobin®, might improve prognosis. The following article offers an overview on adjunctive immunoglobulin therapy in adult patients with severe sepsis. For prophylaxis of sepsis in adults see [1], for prophylaxis and therapy of sepsis in neonates and infants see [1, 2].
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Päsler, M., Dietz, S., Werdan, K. (2012). Hypogammaglobulinemia in Sepsis. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2012. Annual Update in Intensive Care and Emergency Medicine, vol 2012. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25716-2_10
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