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Glycosaminoglycan and Chemokine/Growth Factor Interactions

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Heparin - A Century of Progress

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 207))

Abstract

Heparin and glycosaminoglycans (GAGs) related structurally to heparin, notably heparan sulphate, bind to most, if not all, chemokines and many growth factors. The chemokine and growth factor interactions with GAGs localise the peptide mediators to specific sites in tissues and influence their stability and function. This chapter discusses the nature of these interactions and the effect on the function of a number of chemokines (PF-4, interleukin-8, RANTES and SDF-1) and growth factors (FGF, HGF, VEGF) in normal physiology and the disease setting. Novel therapeutic interventions that target chemokine and growth factor interactions with GAGs are also discussed.

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Authors and Affiliations

  1. Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2UP, UK

    Janis Shute

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  1. Janis Shute
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Correspondence to Janis Shute .

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Editors and Affiliations

  1. School of Pharmacy, University of London, Brunswick Square 29-39, London, WC1N 1AX, United Kingdom

    Rebecca Lever

  2. Standards and Control, National Institute for Biological, Blanche Lane, Potters Bar, Herts., EN6 3QG, United Kingdom

    Barbara Mulloy

  3. King's College London, Sackler Inst. Pulmonary Pharmacology, Waterloo Campus, London, SE1 9NH, United Kingdom

    Clive P. Page

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Shute, J. (2012). Glycosaminoglycan and Chemokine/Growth Factor Interactions. In: Lever, R., Mulloy, B., Page, C. (eds) Heparin - A Century of Progress. Handbook of Experimental Pharmacology, vol 207. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23056-1_13

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