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Fetal and Adult Exposure to Bisphenol-A as a Contributing Factor in the Etiology of the Metabolic Syndrome

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Multi-System Endocrine Disruption

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Abstract

Metabolic disorders such as type 2 diabetes and obesity are among the most challenging health problems on a global scale. The number of patients is increasing worldwide at an alarming rate. Although the underlying cause of the problem is still puzzling, genetic and environmental factors are thought to have a causal influence. Furthermore, widespread human exposure to significant doses of bisphenol-A (BPA) has been reported. BPA is a product commonly used in food and beverage containers that has been demonstrated to interfere with endocrine signaling pathways at low doses during fetal, neonatal or perinatal periods as well as in adulthood. There is also increasing experimental evidence revealing the deleterious effects of BPA on energy balance and glucose homeostasis. In the present review, we will summarize the most relevant findings that confirm the critical role of BPA in the development of metabolic disorders.

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Authors and Affiliations

  1. Instituto de Bioingeniería and CIBERDEM, Universidad Miguel Hernández de Elche, Elche, Spain

    Paloma Alonso-Magdalena & Angel Nadal

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  1. Paloma Alonso-Magdalena
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  2. Angel Nadal
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Correspondence to Paloma Alonso-Magdalena .

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Editors and Affiliations

  1. , Developmental Neuroendocrinology Unit, G, University of Liège, Place du XX Aout 7, Liège, Belgium

    Jean-Pierre Bourguignon

  2. Campus de Beaulieu, GERHM Inserm U625, Avenue du Général Leclerc, Rennes, 35042, France

    Bernard Jégou

  3. Inserm U648, UFR Biomédicale, Centre Universitaire des Saints-Pères, Paris Cedex 06, 75270, France

    Bernard Kerdelhué

  4. , Departments of Physiology and, University of Turku, Kiinamyllynkatu 10, Turku, 20520, Finland

    Jorma Toppari

  5. Fondation Ipsen, Quai Georges Gorse 65, Boulogne-Billancourt, 92100, France

    Yves Christen

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Alonso-Magdalena, P., Nadal, A. (2011). Fetal and Adult Exposure to Bisphenol-A as a Contributing Factor in the Etiology of the Metabolic Syndrome. In: Bourguignon, JP., Jégou, B., Kerdelhué, B., Toppari, J., Christen, Y. (eds) Multi-System Endocrine Disruption. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22775-2_8

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