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Principles of Therapeutic Drug Monitoring

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Pediatric Clinical Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 205))

Abstract

Therapeutic drug monitoring (TDM) is central to optimize drug efficacy in children, because the pharmacokinetics and pharmacodynamics of most drugs differ greatly between children and adults. Many factors should be analyzed to implement TDM in the pediatric population, including a validated pharmacological parameter and an analytical method adapted to children as limited sampling volumes and high sensitivity are required. The use of population approaches, new analytical methods such as saliva and dried blood spots, and pharmacodynamic monitoring give attractive options to improve TDM, individualize therapy in order to optimize efficacy and reduce adverse drug reactions.

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Authors and Affiliations

  1. Department of Pediatric Pharmacology and Pharmacogenetics, Clinical Investigation Center, CIC Inserm 9202, French network of Pediatric Investigation Centers (CICPaed), Hôpital Robert Debré, 48 Boulevard Sérurier, 75935, Paris, France

    Wei Zhao & Evelyne Jacqz-Aigrain

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  1. Wei Zhao
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  2. Evelyne Jacqz-Aigrain
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Correspondence to Evelyne Jacqz-Aigrain .

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Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Univ.Klinikum Marburg, Baldingerstr. 12, Marburg, 35043, Germany

    Hannsjörg W. Seyberth

  2. Karolinska Institutet, Dept. Laboratory Medicine, Karolinska University Hostpital, Stockholm, 141 86, Sweden

    Anders Rane

  3. für Klinische Pharmakologie (IKP), Dr. Margarete Fischer-Bosch Institut, Auerbachstr. 112, Stuttgart, 70376, Germany

    Matthias Schwab

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Zhao, W., Jacqz-Aigrain, E. (2011). Principles of Therapeutic Drug Monitoring. In: Seyberth, H., Rane, A., Schwab, M. (eds) Pediatric Clinical Pharmacology. Handbook of Experimental Pharmacology, vol 205. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20195-0_3

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