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Zebrafish as a Suitable Model for Evaluating Nanocosmetics and Nanomedicines

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Nanocosmetics and Nanomedicines

Abstract

The assessment of complex in vivo phenotypes using the teleost zebrafish provides an alternative tool to combine detailed toxicological studies with the large-scale screening of chemicals. The zebrafish, Danio rerio, represents a versatile model organism with many molecular, morphological, and physiological similarities to mammals. It is well suited for studies in genetics, embryology, development, and cell biology, and, in recent years, it has become an important vertebrate model for small molecule studies. Several characteristics contribute to the growing interest in this tropical fish for high-throughput screening such as its small size, high reproductive capacity, accessibility for genetic manipulation, optical transparency which allows visual assessment of developing cells and organs, suitability for treatment by water exposure, low maintenance costs, and a large and growing biological database. In the present chapter, we outline the use of the zebrafish in biomaterial nanotoxicity studies and the potential of this model for the phenotype-based screening of skin care products.

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Author information

Authors and Affiliations

  1. Laboratory of Bioassays and Signal Transduction, Instituto de Biologia, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, s/n, CP 6109, 13083-970, Campinas, SP, Brazil

    Carmen V. Ferreira

  2. Department of Gastroenterology and Hepatology, Erasmus Medical Center, room L-459,Gravendijkwal 230, NL-3015, CE, Rotterdam, The Netherlands

    Maria A. Sartori-da-Silva

  3. Departamento de Bioquímica (Campus São Paulo), Universidade Federal de São Paulo, 3 de Maio, 100, 04044-020, São Paulo, SP, Brazil

    Giselle Z. Justo

  4. Departamento de Ciências Biológicas (Campus Diadema), Universidade Federal de São Paulo, 3 de Maio, 100, 04044-020, São Paulo, SP, Brazil

    Giselle Z. Justo

Authors
  1. Carmen V. Ferreira
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  2. Maria A. Sartori-da-Silva
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  3. Giselle Z. Justo
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Editor information

Editors and Affiliations

  1. Dept. de Produção e Controle de Medicame, Faculdade de Farmácia, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Brazil

    Ruy Beck

  2. Faculty of Pharmacy, Dept. de Produção e Controle de Medicame, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Brazil

    Silvia Guterres

  3. Institut of Chemistry, Departamento de Química Orgânica, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, Brazil

    Adriana Pohlmann

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Ferreira, C.V., Sartori-da-Silva, M.A., Justo, G.Z. (2011). Zebrafish as a Suitable Model for Evaluating Nanocosmetics and Nanomedicines. In: Beck, R., Guterres, S., Pohlmann, A. (eds) Nanocosmetics and Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19792-5_12

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