Abstract
Nucleotide metabolism occurs in all living organisms. The most prominent biomolecule, in terms of the number of reactions that it participates in, is the nucleotide, ATP. Although nucleotide metabolism is universal, it does differ to some extent in different organisms, e.g., the enzymes of purine nucleotide biosynthesis are separate enzymes in Escherichia coli, whereas some of these same enzymes are part of dual-functional proteins in humans.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Stevens RC, Lipscomb WN (1992) A molecular mechanism for pyrimidine nucleotide control of aspartate transcarbamoylase. Proc Natl Acad Sci USA 89:5281–5285
Portet RW, Modebe MO, Stark GR (1969) Kinetic studies of the catalytic subunit. J Biol Chem 244:1846–1859
Parmentier LE, Weiss PM, O’Leary MH, Schachman HK, Cleland WW (1992) 13C and 15N isotope effects as a probe of the chemical mechanism of Escherichia coli aspartate transcarbamoylase. Biochemistry 31:6577–6584
Kornberg A (1955) Enzymatic synthesis of pyrimidine nucleotides:orotidine-5′-phosphate and uridine-5′-phosphate. J Biol Chem 215:403–451
Goiten RK, Chelsky D, Parsons SM (1978) Primary 14C and α secondary 3H substrate kinetic isotope effects for some phosphoribosyltransferases. J Biol Chem 253:2963–2971
Appleby TC, Kinsland C, Begley TP, Ealick SE (2000) The crystal structure and mechanism of orotidine 5′-monophosphate decarboxylase. Proc Natl Acad Sci USA 97:2005–2010
Gerhart JC, Pardee AB (1962) The enzymology of control by feedback inhibition. J Biol Chem 237:891–896
Buchanan JM (1994) Aspects of nucleotide enzymology and biology. Protein Sci 3:2151–2157
Buchanan JM, Sonne JC, Delluva AM (1948) Biological precursors of uric acid: the role of lactate, glycine, and carbon dioxide as precursors of the carbon chain and nitrogen atom 7 of uric acid. J Biol Chem 173:81–98
Sonne JC, Buchanan JM, Delluva AM (1948) Biological precursors of uric acid: the role of lactate, acetate, and formate in the synthesis of the ureido groups uric acid. J Biol Chem 173:69–79
Bass MB, Fromm HJ, Rudolph FB (1984) The mechanism of the adenylosuccinate synthetase reaction as studied by positional exchange. J Biol Chem 259:12330–12333
Kornberg A, Lieberman I, Simms ES (1955) Enzymatic synthesis of purine nucleotides. J Biol Chem 215:417–427
Ginder ND, Binkowski DJ, Fromm HJ, Honzatko RB (2006) Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazolesuccino-carboxamide synthetase. J Biol Chem 281:20680–20688
Vergis JM, Beardsley GP (2004) Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formy-transferase/inosine monophosphate cyclohydrolase. Biochemistry 43:1184–1192
Zhang Y, Morar M, Ealick SE (2008) Structural biology of the purine biosynthetic pathway. Cell Mol Life Sci 65:3699–3724
Jordan A, Reichard P (1998) Ribonucleotide reductases. Annu Rev Biochem 67:71–98
Carreras CW, Santi DV (1995) The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 64:721–762
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Fromm, H.J., Hargrove, M.S. (2012). Nucleotide Metabolism. In: Essentials of Biochemistry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19624-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-19624-9_14
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19623-2
Online ISBN: 978-3-642-19624-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)