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Mechanics and Regulation of Cell Shape During the Cell Cycle

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Cell Cycle in Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS))

Abstract

Many cell types undergo dramatic changes in shape throughout the cell cycle. For individual cells, a tight control of cell shape is crucial during cell division, but also in interphase, for example during cell migration. Moreover, cell cycle-related cell shape changes have been shown to be important for tissue morphogenesis in a number of developmental contexts. Cell shape is the physical result of cellular mechanical properties and of the forces exerted on the cell. An understanding of the causes and repercussions of cell shape changes thus requires knowledge of both the molecular regulation of cellular mechanics and how specific changes in cell mechanics in turn effect global shape changes. In this chapter, we provide an overview of the current knowledge on the control of cell morphology, both in terms of general cell mechanics and specifically during the cell cycle.

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Acknowledgments

We thank B. Baum, J.S. Bois, S.W. Grill, C. Norden, and G. Salbreux for their comments on the manuscript, A. Rudnick for assistance with the illustrations, and The Polish Ministry for Science and Higher Education, the Max Planck Society, and the Human Frontier Science Program for financial support.

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  1. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany

    Andrew G. Clark & Ewa Paluch

  2. International Institute of Molecular and Cell Biology, Warsaw, Poland

    Andrew G. Clark & Ewa Paluch

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Correspondence to Andrew G. Clark or Ewa Paluch .

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  1. CNRS UMR 6061, Fac. Médecine, Université de Rennes 1, Rennes CX, 35043, France

    Jacek Z. Kubiak

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Clark, A.G., Paluch, E. (2011). Mechanics and Regulation of Cell Shape During the Cell Cycle. In: Kubiak, J. (eds) Cell Cycle in Development. Results and Problems in Cell Differentiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19065-0_3

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