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Stoichiometric Foundation of Large-Scale Biochemical System Analysis

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Modelling in Molecular Biology

Part of the book series: Natural Computing Series ((NCS))

Abstract

The traditional approach to unraveling functions of a biochemical system is to study isolated enzymes and/or complexes, and to determine their kinetic mechanisms for catalyzing given biochemical reactions along with estimates of the associated parameter values [41,47]. While this reductionist approach has been fruitful, the buzzwords of the present are integration and systems. One of the important tasks in current computational biology is to assimilate and integrate the behaviour of interacting systems of many enzymes and reactants. Understanding of such systems lays the foundation for modelling and simulation of whole-cell systems, a defining goal of the current era of biomedical science.

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Author information

Authors and Affiliations

  1. Bioengineering, University of Washington, Seattle, WA

    Daniel A. Beard & James B. Bassingthwaighte

  2. Applied Mathematics and Bioengineering, University of Washington, Seattle

    Hong Qian

Authors
  1. Daniel A. Beard
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  2. Hong Qian
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  3. James B. Bassingthwaighte
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Editor information

Editors and Affiliations

  1. Institute of Computer Science, Romanian Academy of Sciences, 700506, Iasi, Romania

    Gabriel Ciobanu

  2. Institute of Advanced Computer Science, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands

    Grzegorz Rozenberg

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Beard, D.A., Qian, H., Bassingthwaighte, J.B. (2004). Stoichiometric Foundation of Large-Scale Biochemical System Analysis. In: Ciobanu, G., Rozenberg, G. (eds) Modelling in Molecular Biology. Natural Computing Series. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18734-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-18734-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62269-4

  • Online ISBN: 978-3-642-18734-6

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