Skip to main content
SpringerLink
Log in

Simultaneous Topography and Recognition Imaging

  • Chapter
  • First Online:
Scanning Probe Microscopy in Nanoscience and Nanotechnology

Part of the book series: NanoScience and Technology ((NANO))

Summary

Atomic force microscopy (AFM) has developed into a key technique for the investigation of biological samples. In contrast to other microscopy methods, high lateral resolution down to the nanometer scale and measurements under physiological conditions are possible. Additionally, the piconewton force sensitivity allows accurate data collection for single-molecule interactions. This chapter describes the combination of high-resolution imaging and single-molecule interaction measurements. In the so-called topography and recognition imaging (TREC) mode, the scanning AFM tip is upgraded into a molecular sensor by anchoring a ligand to the tip. Enhanced electronics, including a recently developed feedback loop, allow measurement of the sample topography while simultaneously mapping ligand-binding sites. This results in topography images recorded alongside with recognition images, thereby allowing accurate allocation of the binding sites with a lateral resolution of one to a few nanometers. TREC has been successfully used for recognition imaging on isolated proteins, native and artificial membranes, and cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. Binnig, C.F. Quate, C. Gerber, Phys. Rev. Lett. 56, 930 (1986).

    Article  PubMed  ADS  Google Scholar 

  2. B.P. Jena, S.J. Cho, Methods Cell. Biol. 68, 33 (2002).

    Article  PubMed  CAS  Google Scholar 

  3. E.L. Florin, V.T. Moy, H.E. Gaub, Science 264, 415 (1994).

    Article  PubMed  ADS  CAS  Google Scholar 

  4. G.U. Lee, A.C. Chrisey, R.J. Colton, Langmuir 10, 354 (1994).

    Article  CAS  Google Scholar 

  5. P. Hinterdorfer, W. Baumgartner, H.J. Gruber, K. Schilcher, H. Schindler, Proc. Natl. Acad. Sci. USA 93, 3477 (1996).

    Article  PubMed  ADS  CAS  Google Scholar 

  6. A.F. Oberhauser, P.E. Marszalek, H.P. Erickson, J.M. Fernandez, Nature 393, 181 (1998).

    Article  PubMed  ADS  CAS  Google Scholar 

  7. E. Evans, K. Ritchie, Biophys. J. 72, 1541 (1997).

    Article  PubMed  CAS  Google Scholar 

  8. J. Fritz, A.G. Katopodis, F. Kolbinger, D. Anselmetti, Proc. Natl. Acad. Sci. USA 95, 12283 (1998).

    Article  PubMed  ADS  CAS  Google Scholar 

  9. R. Ros, F. Schwesinger, D. Anselmetti, M. Kubon, R. Schafer, A. Pluckthun, L. Tiefenauer, Proc. Natl. Acad. Sci. USA 95, 7402 (1998).

    Article  PubMed  ADS  CAS  Google Scholar 

  10. T. Strunz, K. Oroszlan, R. Schafer, H.J. Guntherodt, Proc. Natl. Acad. Sci. USA 96, 11277 (1999).

    Article  PubMed  ADS  CAS  Google Scholar 

  11. F. Schwesinger, R. Ros, T. Strunz, D. Anselmetti, H.J. Guntherodt, A. Honegger, L. Jermutus, L. Tiefenauer, A. Pluckthun, Proc. Natl. Acad. Sci. USA 97, 9972 (2000).

    Article  PubMed  ADS  CAS  Google Scholar 

  12. W. Baumgartner, P. Hinterdorfer, W. Ness, A. Raab, D. Vestweber, H. Schindler, D. Drenckhahn, Proc. Natl. Acad. Sci. USA 97, 4005 (2000).

    Article  PubMed  ADS  CAS  Google Scholar 

  13. F. Kienberger, G. Kada, H.J. Gruber, V. Pastushenko, C. Riener, M. Trieb, H.-G. Knaus, H. Schindler, P. Hinterdorfer, Single Mol. 1, 59 (2000).

    Article  ADS  CAS  Google Scholar 

  14. C. Yuan, A. Chen, P. Kolb, V.T. Moy, Biochemistry 39, 10219 (2000).

    Article  PubMed  CAS  Google Scholar 

  15. P. Hinterdorfer, K. Schilcher, W. Baumgartner, H.J. Gruber, H. Schindler, Nanobiol. 4, 177 (1998).

    CAS  Google Scholar 

  16. V.T. Moy, E.L. Florin, H.E. Gaub, Science 266, 257 (1994).

    Article  PubMed  ADS  CAS  Google Scholar 

  17. A. Chilkoti, T. Boland, B.D. Ratner, P.S. Stayton, Biophys. J. 69, 2125 (1995).

    Article  PubMed  ADS  CAS  Google Scholar 

  18. R. Merkel, P. Nassoy, A. Leung, K. Ritchie, E. Evans, Nature 397, 50 (1999).

    Article  PubMed  ADS  CAS  Google Scholar 

  19. M. Rief, M. Gautel, F. Oesterhelt, J.M. Fernandez, H.E. Gaub, Science 276, 1109 (1997).

    Article  PubMed  CAS  Google Scholar 

  20. P.E. Marszalek, A.F. Oberhauser, Y.P. Pang, J.M. Fernandez, Nature 396, 661 (1998).

    Article  PubMed  ADS  CAS  Google Scholar 

  21. F. Kienberger, V.P. Pastushenko, G. Kada, H.J. Gruber, C. Riener, H. Schindler, P. Hinterdorfer, Single Mole. 1, 123 (2000).

    Article  ADS  CAS  Google Scholar 

  22. J. Preiner, H. Janovjak, C. Rankl, H. Knaus, D.A. Cisneros, A. Kedrov, F. Kienberger, D.J. Muller, P. Hinterdorfer, Biophys. J. 93, 930 (2007).

    Article  PubMed  ADS  CAS  Google Scholar 

  23. G. Hummer, A. Szabo, Proc. Natl. Acad. Sci. USA 98, 3658 (2001).

    Article  PubMed  ADS  CAS  Google Scholar 

  24. H.A. Mizes, K.G. Loh, R.J.D. Miller, S.K. Ahuja, E.F. Grabowski, Appl. Phys. Lett. 59, 2901 (1991).

    Article  ADS  CAS  Google Scholar 

  25. M. Radmacher, J.P. Cleveland, M. Fritz, H.G. Hansma, P.K. Hansma, Biophys. J. 66, 2159 (1994).

    Article  PubMed  ADS  CAS  Google Scholar 

  26. C.A.J. Putman, K.O. Vanderwerf, B.G. Degrooth, N.F. Vanhulst, J. Greve, Appl. Phys. Lett. 64, 2454 (1994).

    Article  ADS  CAS  Google Scholar 

  27. M. Ludwig, W. Dettmann, H.E. Gaub, Biophys. J. 72, 445 (1997).

    Article  PubMed  ADS  CAS  Google Scholar 

  28. O.H. Willemsen, M.M. Snel, K.O. van der Werf, B.G. de Grooth, J. Greve, P. Hinterdorfer, H.J. Gruber, H. Schindler, Y. van Kooyk, C.G. Figdor, Biophys. J. 75, 2220 (1998).

    Article  PubMed  CAS  Google Scholar 

  29. M. Grandbois, W. Dettmann, M. Benoit, H.E. Gaub, J. Histochem. Cytochem. 48, 719 (2000).

    PubMed  CAS  Google Scholar 

  30. P.P. Lehenkari, G.T. Charras, A. Nykanen, M.A. Horton, Ultramicroscopy 82, 289 (2000).

    Article  PubMed  CAS  Google Scholar 

  31. N. Almqvist, R. Bhatia, G. Primbs, N. Desai, S. Banerjee, R. Lal, Biophys. J. 86, 1753 (2004).

    Article  PubMed  ADS  CAS  Google Scholar 

  32. M.B. Viani, T.E. Schaffer, A. Chand, M. Rief, H.E. Gaub, P.K. Hansma, J. Appl. Phys. 86, 2258 (1999).

    Article  ADS  CAS  Google Scholar 

  33. T.E. Schaffer, Y.K. Jiao, Biophys. J. 80, 303A (2001).

    Google Scholar 

  34. A. Raab, W. Han, D. Badt, S.J. Smith-Gill, S.M. Lindsay, H. Schindler, P. Hinterdorfer, Nat. Biotechnol. 17, 901 (1999).

    Article  PubMed  CAS  Google Scholar 

  35. H. Schindler, D. Badt, P. Hinterdorfer, F. Kienberger, A. Raab, S. Wielert-Badt, V. Pastushenko, Ultramicroscopy 82, 227 (2000).

    Article  PubMed  CAS  Google Scholar 

  36. W.H. Han, S.M. Lindsay, T.W. Jing, Appl. Phys. Lett. 69, 4111 (1996).

    Article  ADS  CAS  Google Scholar 

  37. W. Han, M. Dlakic, Y.J. Zhu, S.M. Lindsay, R.E. Harrington, Proc. Natl. Acad. Sci. USA 94, 10565 (1997).

    Article  PubMed  ADS  CAS  Google Scholar 

  38. W. Han, S.M. Lindsay, M. Dlakic, R.E. Harrington, Nature 386, 563 (1997).

    Article  PubMed  ADS  CAS  Google Scholar 

  39. F. Kienberger, C. Stroh, G. Kada, R. Moser, W. Baumgartner, V. Pastushenko, C. Rankl, U. Schmidt, H. Muller, E. Orlova, C. LeGrimellec, D. Drenckhahn, D. Blaas, P. Hinterdorfer, Ultramicroscopy 97, 229 (2003).

    Article  PubMed  CAS  Google Scholar 

  40. C.M. Stroh, A. Ebner, M. Geretschlager, G. Freudenthaler, F. Kienberger, A.S.M. Kamruzzahan, S.J. Smith-Gill, H.J. Gruber, P. Hinterdorfer, Biophys. J. 87, 1981 (2004).

    Article  PubMed  ADS  CAS  Google Scholar 

  41. A. Ebner, F. Kienberger, G. Kada, C.M. Stroh, M. Geretschlager, A.S. Kamruzzahan, L. Wildling, W.T. Johnson, B. Ashcroft, J. Nelson, S.M. Lindsay, H.J. Gruber, P. Hinterdorfer, Chem. Phys. Chem. 6, 897 (2005).

    PubMed  CAS  Google Scholar 

  42. C.M. Stroh, A. Ebner, M. Geretschlager, G. Freudenthaler, F. Kienberger, A.S. Kamruzzahan, S.J. Smith-Gill, H.J. Gruber, P. Hinterdorfer, Biophys. J. 87, 1981 (2004).

    Article  PubMed  ADS  CAS  Google Scholar 

  43. J. Preiner, N. Losilla, A. Ebner, P. Annibale, F. Biscarini, R. Garcia, P. Hinterdorfer, Nano Lett. 9, 571 (2009).

    Article  PubMed  ADS  CAS  Google Scholar 

  44. C. Stroh, H. Wang, R. Bash, B. Ashcroft, J. Nelson, H. Gruber, D. Lohr, S.M. Lindsay, P. Hinterdorfer, Proc. Natl. Acad. Sci. USA 101, 12503 (2004).

    Article  PubMed  ADS  CAS  Google Scholar 

  45. J. Tang, A. Ebner, H. Badelt-Lichtblau, C. Vollenkle, C. Rankl, B. Kraxberger, M. Leitner, L. Wildling, H.J. Gruber, U.B. Sleytr, Nano Lett. 8, 4312 (2008).

    Article  PubMed  ADS  CAS  Google Scholar 

  46. A. Ebner, D. Nikova, T. Lange, J. Haberle, S. Falk, A. Dubbers, R. Bruns, P. Hinterdorfer, H. Oberleithner, H. Schillers, Nanotechnology 19 (2008).

    Google Scholar 

  47. L. Chtcheglova, J. Waschke, L. Wildling, D. Drenckhahn, P. Hinterdorfer, Biophys. J. (2007).

    Google Scholar 

  48. L. Chtcheglova, F. Atalar, U. Ozbek, L. Wildling, A. Ebner, P. Hinterdorfer, Pflügers Archiv Eur. J. Physiol.ogy (2008).

    Google Scholar 

  49. S. Lee, J. Mandic, K.V. Vliet, Proc. Natl. Acad. Sci. 104, 9609 (2007).

    Article  PubMed  ADS  CAS  Google Scholar 

  50. K.C. Langry, T.V. Ratto, R.E. Rudd, M.W. McElfresh, Langmuir 21, 12064 (2005).

    Article  PubMed  CAS  Google Scholar 

  51. T.V. Ratto, K.C. Langry, R.E. Rudd, R.L. Balhorn, M.J. Allen, M.W. McElfresh, Biophys. J. 86, 2430 (2004).

    Article  PubMed  ADS  CAS  Google Scholar 

  52. B. Cross, F. Ronzon, B. Roux, J.P. Rieu, Langmuir 21, 5149 (2005).

    Article  PubMed  CAS  Google Scholar 

  53. P. Desmeules, M. Grandbois, V.A. Bondarenko, A. Yamazaki, C. Salesse, Biophys. J. 82, 3343 (2002).

    Article  PubMed  CAS  Google Scholar 

  54. A. Touhami, B. Hoffmann, A. Vasella, F.A. Denis, Y.F. Dufrene, Langmuir 19, 1745 (2003).

    Article  CAS  Google Scholar 

  55. A. Touhami, M.H. Jericho, T.J. Beveridge, Langmuir 23, 2755 (2007).

    Article  PubMed  CAS  Google Scholar 

  56. L. Schmitt, M. Ludwig, H.E. Gaub, R. Tampe, Biophys. J. 78, 3275 (2000).

    Article  PubMed  CAS  Google Scholar 

  57. M. Conti, G. Falini, B. Samori, Angewandte Chemie 112 (2000).

    Google Scholar 

  58. A. Ebner, F. Kienberger, G. Kada, C.M. Stroh, M. Geretschlager, A.S.M. Kamruzzahan, L. Wildling, W.T. Johnson, B. Ashcroft, J. Nelson, S.M. Lindsay, H.J. Gruber, P. Hinterdorfer, Chem. Phys. Chem. 6, 897 (2005).

    PubMed  CAS  Google Scholar 

  59. C.K. Riener, C.M. Stroh, A. Ebner, C. Klampfl, A.A. Gall, C. Romanin, Y.L. Lyubchenko, P. Hinterdorfer, H.J. Gruber, Analytica Chimica Acta 479, 59 (2003).

    Article  CAS  Google Scholar 

  60. R. Ros, F. Schwesinger, D. Anselmetti, M. Kubon, R. Schäfer, A. Plückthun, L. Tiefenauer, Proc. Natl. Acad. Sci. USA, 95, 7402.

    Google Scholar 

  61. A.S.M. Kamruzzahan, A. Ebner, L. Wildling, F. Kienberger, C.K. Riener, C.D. Hahn, P.D. Pollheimer, P. Winklehner, M. Holzl, B. Lackner, D.M. Schorkl, P. Hinterdorfer, H.J. Gruber, Bioconjug. Chem. 17, 1473 (2006).

    Article  PubMed  CAS  Google Scholar 

  62. T. Haselgrubler, A. Amerstorfer, H. Schindler, H.J. Gruber, Bioconjug. Chem. 6, 242 (1995).

    Article  PubMed  CAS  Google Scholar 

  63. S. Wielert-Badt, P. Hinterdorfer, H.J. Gruber, J.-T. Lin, D. Badt, B. Wimmer, H. Schindler, R.K.-H. Kinne, Biophys. J. 82, 2767 (2002).

    Article  PubMed  CAS  Google Scholar 

  64. T. Puntheeranurak, L. Wildling, H.J. Gruber, R.K.H. Kinne, P. Hinterdorfer, J. Cell Sci. 119, 2960 (2006).

    Article  PubMed  CAS  Google Scholar 

  65. T. Puntheeranurak, B. Wimmer, F. Castaneda, H.J. Gruber, P. Hinterdorfer, R.K.H. Kinne, Biochemistry 46, 2797 (2007).

    Article  PubMed  CAS  Google Scholar 

  66. M. Morpurgo, F.M. Veronese, D. Kachensky, J.M. Harris, Bioconjug. Chem. 7, 363 (1996).

    Article  PubMed  CAS  Google Scholar 

  67. W. Grange, T. Strunz, I. Schumakovitch, H.J. Guntherodt, M. Hegner, Single Mole. 2, 75 (2001).

    Article  ADS  CAS  Google Scholar 

  68. L. Lin, H. Wang, Y. Liu, H. Yan, S. Lindsay, Biophys. J. 90, 4236 (2006).

    Article  PubMed  ADS  CAS  Google Scholar 

  69. T. Strunz, K. Oroszlan, I. Schumakovitch, H. Guntherodt, M. Hegner, Biophys. J. 79, 1206 (2000).

    Article  PubMed  CAS  Google Scholar 

  70. H.G. Linde, J. Appl. Polym. Sci. 40, 613 (1990).

    Article  CAS  Google Scholar 

  71. R. Nevo, C. Stroh, F. Kienberger, D. Kaftan, V. Brumfeld, M. Elbaum, Z. Reich, P. Hinterdorfer, Nat. Struc. Biol. 10, 553 (2003).

    Article  CAS  Google Scholar 

  72. C.K. Riener, F. Kienberger, C.D. Hahn, G.M. Buchinger, I.O.C. Egwim, T. Haselgrubler, A. Ebner, C. Romanin, C. Klampfl, B. Lackner, Analytica Chimica Acta 497, 101 (2003).

    Article  CAS  Google Scholar 

  73. B. Bonanni, A.S.M. Kamruzzahan, A.R. Bizzarri, C. Rankl, H.J. Gruber, P. Hinterdorfer, S. Cannistraro, Biophys. J. 89, 2783 (2005).

    Article  PubMed  CAS  Google Scholar 

  74. A. Ebner, L. Wildling, A.S.M. Kamruzzahan, C. Rankl, J. Wruss, C.D. Hahn, M. Holzl, R. Zhu, F. Kienberger, D. Blaas, P. Hinterdorfer, H.J. Gruber, Bioconjug. Chem. 18, 1176 (2007).

    Article  PubMed  CAS  Google Scholar 

  75. E.J. Hukkanen, J.A. Wieland, D.E. Leckband, R.D. Braatz, 2005, pp. 3265.

    Google Scholar 

  76. J.A. Wieland, A.A. Gewirth, D.E. Leckband, J. Biologic. Chem. 280, 41037 (2005).

    Article  CAS  Google Scholar 

  77. A. Ebner, P. Hinterdorfer, H.J. Gruber, Ultramicroscopy 107, 922 (2007).

    Article  PubMed  CAS  Google Scholar 

  78. R. Avci, M. Schweitzer, R.D. Boyd, J. Wittmeyer, A. Steele, J. Toporski, W. Beech, F.T. Arce, B. Spangler, K.M. Cole, D.S. McKay, Langmuir 20, 11053 (2004).

    Article  PubMed  CAS  Google Scholar 

  79. R. Horn, S. Ding, H.J. Gruber, J. General Physiol. 116, 461 (2000).

    Article  CAS  Google Scholar 

  80. K.L. Prime, G.M. Whitesides, 252, 1164 (1991).

    Google Scholar 

  81. C. Verbelen, H.J. Gruber, Y.F. Dufrene, J. Molecul. Recog. 20 (2007).

    Google Scholar 

  82. J.L. Tang, A. Ebner, N. Ilk, H. Lichtblau, C. Huber, R. Zhu, D. Pum, M. Leitner, V. Pastushenko, H.J. Gruber, U.B. Sleytr, P. Hinterdorfer, Langmuir 24, 1324 (2008).

    Article  PubMed  CAS  Google Scholar 

  83. L. Wildling, P. Hinterdorfer, K. Kusche-Vihrog, Y. Treffner, H. Oberleithner, Pflugers Arch. 2008, in press.

    Google Scholar 

  84. W. Han, S.M. Lindsay, T. Jing, Appl. Phys. Lett. 69, 4111 (1996).

    Article  ADS  CAS  Google Scholar 

  85. A. Ebner, L. Wildling, R. Zhu, C. Rankl, T. Haselgrubler, P. Hinterdorfer, H.J. Gruber, Stm And Afm Studies On (Bio)Molecular Systems: Unravelling The Nanoworld 285, 29 (2008).

    Google Scholar 

  86. J. Preiner, J.L. Tang, V. Pastushenko, P. Hinterdorfer, Phys. Rev. Lett. 99 (2007).

    Google Scholar 

  87. Q. Zhong, D. Inniss, K. Kjoller, V.B. Elings, Surf. Sci. 290, L688 (1993).

    Article  CAS  Google Scholar 

  88. Y. Martin, C.C. Williams, H.K. Wickramasinghe, J. Appl. Phys. 61, 4723 (1987).

    Article  ADS  CAS  Google Scholar 

  89. M. Lantz, Y.Z. Liu, X.D. Cui, H. Tokumoto, S.M. Lindsay, Interface Anal. 27, 354 (1999).

    Article  CAS  Google Scholar 

  90. C. Stroh, H. Wang, R. Bash, B. Ashcroft, J. Nelson, H. Gruber, D. Lohr, S.M. Lindsay, P. Hinterdorfer, Proc. Natl. Acad. Sci. USA 101, 12503 (2004).

    Article  PubMed  ADS  CAS  Google Scholar 

  91. J. Preiner, N. Losilla, A. Ebner, P. Annibale, F. Biscarini, R. Garcia, P. Hinterdorfer, Nano Lett. 9, 571 (2009).

    Article  PubMed  ADS  CAS  Google Scholar 

  92. P. Hinterdorfer, Y.F. Dufrene, Nat. Method. 3, 347 (2006).

    Article  CAS  Google Scholar 

  93. J.L. Tang, A. Ebner, H. Badelt-Lichtblau, C. Vollenkle, C. Rankl, B. Kraxberger, M. Leitner, L. Wildling, H.J. Gruber, U.B. Sleytr, N. Ilk, P. Hinterdorfer, Nano Lett. 8, 4312 (2008).

    Article  PubMed  ADS  CAS  Google Scholar 

  94. L.A. Chtcheglova, J. Waschke, L. Wildling, D. Drenckhahn, P. Hinterdorfer, Biophys. J. 93, L11 (2007).

    Article  PubMed  CAS  Google Scholar 

  95. L.A. Chtcheglova, F. Atalar, U. Ozbek, L. Wildling, A. Ebner, P. Hinterdorfer, Pflugers Archiv-Eur. J. Physiol. 456, 247 (2008).

    Article  CAS  Google Scholar 

  96. U.B. Sleytr, P. Messner, D. Pum, M. Sara, Angewandte Chemie – Int. Ed. 38, 1035 (1999).

    Google Scholar 

  97. U.B. Sleytr, M. Sara, D. Pum, B. Schuster, Prog. Surface Sci. 68, 231 (2001).

    Article  ADS  CAS  Google Scholar 

  98. U.B. Sleytr, C. Huber, N. Ilk, D. Pum, B. Schuster, E.M. Egelseer, Fems. Microbiol. Lett. 267, 131 (2007).

    Article  PubMed  CAS  Google Scholar 

  99. U.B. Sleytr, E.M. Egelseer, N. Ilk, D. Pum, B. Schuster, Febs J. 274, 323 (2007).

    Article  PubMed  CAS  Google Scholar 

  100. E.M. Schwiebert, D.J. Benos, C.M. Fuller, Am. J. Med. 104, 576 (1998).

    Article  PubMed  CAS  Google Scholar 

  101. G.M. Braunstein, R.M. Roman, J.P. Clancy, B.A. Kudlow, A.L. Taylor, V.G. Shylonsky, B. Jovov, K. Peter, T. Jilling, Ismailov, II, D.J. Benos, L.M. Schwiebert, J.G. Fitz, E.M. Schwiebert, J. Biologic. Chem. 276, 6621 (2001).

    Google Scholar 

  102. N. Kalin, A. Claass, M. Sommer, E. Puchelle, B. Tummler, J. Clin. Invest. 103, 1379 (1999).

    Article  PubMed  CAS  Google Scholar 

  103. F. Dupuit, N. Kalin, S. Brezillon, J. Hinnrasky, B. Tummler, E. Puchelle, J. Clin. Invest. 96, 1601 (1995).

    Article  PubMed  CAS  Google Scholar 

  104. C. Haws, W.E. Finkbeiner, J.H. Widdicombe, J.J. Wine, Am. J. Physiol. 266, L502 (1994).

    PubMed  CAS  Google Scholar 

  105. M.J. Hug, I.E. Thiele, R. Greger, Pflugers Archiv-Eur. J. Physiol. 434, 779 (1997).

    Article  CAS  Google Scholar 

  106. D. Penque, F. Mendes, S. Beck, C. Farinha, P. Pacheco, P. Nogueira, J. Lavinha, R. Malho, M.D. Amaral, Lab. Invest. 80, 857 (2000).

    PubMed  CAS  Google Scholar 

  107. K.M. Sterling, S. Shah, R.J. Kim, N.I.F. Johnston, A.Y. Salikhova, E.H. Abraham, J. Cell. Biochem. 91, 1174 (2004).

    Article  PubMed  CAS  Google Scholar 

  108. R.S. Sprague, M.L. Ellsworth, A.H. Stephenson, M.E. Kleinhenz, A.J. Lonigro, Am. J. Physiol.-Heart Circulat. Physiol. 275, H1726 (1998).

    CAS  Google Scholar 

  109. T. Lange, P. Jungmann, J. Haberle, S. Falk, A. Duebbers, R. Bruns, A. Ebner, P. Hinterdorfer, H. Oberleithner, H. Schillers, Mole. Memb. Biol. 23, 317 (2006).

    Article  CAS  Google Scholar 

  110. K.I. Willig, S.O. Rizzoli, V. Westphal, R. Jahn, S.W. Hell, Nature 440, 935 (2006).

    Article  PubMed  ADS  CAS  Google Scholar 

  111. M. Koopman, A. Cambi, B.I. de Bakker, B. Joosten, C.G. Figdor, N.F. van Hulst, M.F. Garcia-Parajo, Febs Lett. 573, 6 (2004).

    Article  PubMed  CAS  Google Scholar 

  112. T. Schmidt, G.J. Schutz, W. Baumgartner, H.J. Gruber, H. Schindler, Proc. Natl. Acad. Sci. USA 93, 2926 (1996).

    Article  PubMed  ADS  CAS  Google Scholar 

  113. J.K. Horber, M.J. Miles, Science 302, 1002 (2003).

    Article  PubMed  ADS  CAS  Google Scholar 

  114. P.A. Vincent, K.Y. Xiao, K.M. Buckley, A.P. Kowalczyk, Am. J. Physiol.-Cell Physiol. 286, C987 (2004).

    Article  CAS  Google Scholar 

  115. H. Oberleithner, S.W. Schneider, L. Albermann, U. Hillebrand, T. Ludwig, C. Riethmüller, V. Shahin, C. Schäfer, H. Schillers, J. Memb. Biol. 196, 163 (2003).

    Article  CAS  Google Scholar 

  116. G.B. Gurrola, B. Rosati, M. Rocchetti, G. Pimienta, A. Zaza, A. Arcangeli, M. Olivotto, L.D. Possani, E. Wanke, Faseb J. 13, 953 (1999).

    PubMed  CAS  Google Scholar 

  117. L. Pardo-Lopez, M. Zhang, J. Liu, M. Jiang, L.D. Possani, G.N. Tseng, J. Biologic. Chem. 277, 16403 (2002)

    Article  CAS  Google Scholar 

  118. A.M. Torres, P. Bansal, P.F. Alewood, J.A. Bursill, P.W. Kuchel, J.I. Vandenberg, Febs Lett. 539, 138 (2003).

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the European community projects BioLightTouch (FP6–2004-NEST-C-1–028781), Imunanomap (MRTN-CT-2006–035946), and SMW (MNT-2007–213717), the Austrian Science Foundation (F 3503-B11), and the Austrian Christian Doppler Society.

Author information

Authors and Affiliations

  1. Institute for Biophysics University of Linz, Altenbergerstr. 69, 4040, Linz, Austria

    A. Ebner, L. A. Chtcheglova, J. Preiner, J. Tang, L. Wildling, H. J. Gruber & P. Hinterdorfer

Authors
  1. A. Ebner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. A. Chtcheglova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Preiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Wildling
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. J. Gruber
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. Hinterdorfer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Ebner .

Editor information

Editors and Affiliations

  1. Nanoprobe Lab. Bio- & Nanotechnology &, Ohio State University, West 19th Avenue 201, Columbus, 43210-1142, U.S.A.

    Bharat Bhushan

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ebner, A. et al. (2010). Simultaneous Topography and Recognition Imaging. In: Bhushan, B. (eds) Scanning Probe Microscopy in Nanoscience and Nanotechnology. NanoScience and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03535-7_10

Download citation

Publish with us

Policies and ethics

Search

Navigation