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Advanced Biomimetic Implants Based on Nanostructured Coatings Synthesized by Pulsed Laser Technologies

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Laser-Surface Interactions for New Materials Production

Part of the book series: Springer Series in Materials Science ((SSMATERIALS,volume 130))

Summary

Calcium phosphates (CaPs) are alternative substitutes for human bones and so primary candidates for the manufacture of medical implants. Unfortunately, they do not withstand stress in bulk. To overcome this obstacle, a solution was developed to cover metallic implants with functional biomimetic layers.

Pulsed laser deposition (PLD) has proved to be a competitive method to grow high-quality biomaterial thin films. Nevertheless, in case of very complex, delicate biomolecules (such as organic and biopolymeric materials), PLD provokes an irreversible damage of the chemical bonds and thus the compositional change in the deposited film. This disadvantage is eliminated by matrix-assisted pulsed laser evaporation (MAPLE), capable of transferring large-molecular-mass compounds at very low temperatures.

In this chapter, we review the potential of PLD applied to different types of simple and/or doped CaP coatings. We also scrutinize the extension of MAPLE to the synthesis of hybrid organic–inorganic bionanocomposites for advanced biomimetic implants. Expected development and progress of the new in vitro and in vivo studies are discussed.

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Acknowledgements

AB, INM and CR acknowledge the mobility exchange under the 15th Italian–Romanian Executive Programme of S&T Co-operation project “New Biomimetic Calcium Phosphate Coatings for Metallic Implants.” IM, INM and CR acknowledge also the bilateral Agreement for Scientific Cooperation between the Israel Academy of Sciences and Humanities and Romanian Academy under the theme “Thin films and structures for medical, chemical and biological applications.” All authors acknowledge with thanks the partial support of the work by EU under the contract SIMI G5RD-CT-2000–00423.

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Authors and Affiliations

  1. National Institute for Lasers, Plasma and Radiation Physics, MG-54, RO-77125, Bucharest, Magurele, Romania

    Ion N. Mihailescu & Carmen Ristoscu

  2. Department of Chemistry “G. Ciamician,”, University of Bologna, via Selmi, 2, Bologna, 40126, Italy

    Adriana Bigi

  3. Institute of Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel

    Isaac Mayer

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  1. Ion N. Mihailescu
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  2. Carmen Ristoscu
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Correspondence to Ion N. Mihailescu .

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  1. Dipto. Fisica , Universita di Trento, Via Sommarive 14, Povo, 38050, Italy

    Antonio Miotello

  2. Dipto. Ingegneria Nucleare, Politecnico di Milano, Via Ponzio 34-3, Milano, 20133, Italy

    Paolo M. Ossi

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Mihailescu, I.N., Ristoscu, C., Bigi, A., Mayer, I. (2010). Advanced Biomimetic Implants Based on Nanostructured Coatings Synthesized by Pulsed Laser Technologies. In: Miotello, A., Ossi, P. (eds) Laser-Surface Interactions for New Materials Production. Springer Series in Materials Science, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03307-0_10

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