Abstract
Many years of research efforts have led to the large-scale production of poly[(R)-3-hydroxybutyrate], copolymers of (R)-3-hydroxybutyrate and (R)-3-hydroxyvalerate, copolymers of (R)-3-hydroxybutyrate and 4-hydroxybutyrate, as well as copolymers of (R)-3-hydroxybutyrate and (R)-3-hydroxyhexanoate. A small amount of medium-chain-length polyhydroxyalkanoate (PHA) has also been reported to have been produced. Worldwide, 24 companies are known to be engaged in PHA production and applications. Beginning from 2009, more than 10,000 PHA will be available on the market, and new applications are expected to be developed when large amounts of PHA are available for exploitation. In the future, the large scale of PHA applications will be dependent on the production cost. Therefore, it is very urgent to develop low-cost PHA production technology, including those of continuous and nonsterile processes based on mixed cultures and mixed substrates.
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References
Akiyama M, Tsuge T, Doi Y (2003) Environmental life cycle comparison of polyhydroxyalkanoates produced from renewable carbon resources by bacterial fermentation. Polym Degrad Stab 80:183–194
Brandl H, Cross RA, Lenz RW, Fuller C (1988) Pseudomonas oleovorans as a source of poly(β-hydroxyalkanoates) for potential applications as biodegradable polyesters. Appl Environ Microbiol 54:1977–1982
Byrom D (1992) Production of poly-β-hydroxybutyrate and poly-β-hydroxyvalerate copolymers. FEMS Microbiol Rev 103:247–250
Chen GQ (1989) Produktion von Poly-D(-)-3-Hydroxybuttersäure und Poly-D(-)-3-Hydroxyvaleriansäure mit Einzel- und Mischpopulation von Alcaligenes latus DSM 1122, 1123 bzw. 1124. PhD thesis, Graz University of Technology, Graz
Chen GQ (2009) A polyhydroxyalkanoates based bio- and materials industry. Chem Soc Rev. doi:10.1039/B812677C 38:2434–2446
Chen GQ, Wu Q (2005a) Polyhydroxyalkanoates as tissue engineering materials. Biomaterials 26:6565–6578
Chen GQ, Wu Q (2005b) Microbial production and applications of chiral hydroxyalkanoates. Appl Microbiol Biotechnol 67:592–599
Chen GQ, Koenig KH, Lafferty RM (1991) Production of poly-D(-)-3-hydroxybutyrate and poly-D(-)-3-hydroxyvalerate by strains of Alcaligenes latus. Antonie Van Leewenhoek 60:61–66
Chen GQ, Zhang G, Park SJ, Lee SY (2001) Industrial production of poly(hydroxybutyrate-co-hydroxyhexanoate). Appl Microbiol Biotechnol 57:50–55
Hanggi UJ (1990) Pilot scale production of PHB with Alcaligenes latus. In: Dawes ED (ed) Novel biodegradable microbial polymers. Kluwer, Dordrecht, pp 65–70
Hrabak O (1992) Industrial production of poly-β-hydroxybutyrate. FEMS Microbiol Rev 103:251–256
Jung K, Hazenberg W, Prieto M, Witholt B (2001) Two-stage continuous process development for the production of medium-chain-length poly(3-hydroxyalkanoates). Biotechnol Bioeng 72:19–24
Lu XY, Wu Q, Chen GQ (2003) Enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) via manipulating the fatty acid oxidation pathway in E. coli. FEMS Microbiol Lett 221:97–101
Lu XY, Wu Q, Chen GQ (2004) Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) with flexible 3-hydroxyhexanoate content in Aeromonas hydrophila CGMCC 0911. Appl Microbiol Biotechnol 64:41–45
Nonato RV, Mantelatto PE, Rossell CEV (2001) Integrated production of biodegradable plastic, sugar and ethanol. Appl Microbiol Biotechnol 57:1–5
Qiu YZ, Ouyang SP, Wu Q, Chen GQ (2004) Metabolic engineering for production of copolyesters consisting of 3-hydroxybutyrate and 3-hydroxyhexanoate by recombinant Aeromonas hydrophila harboring phbA and phbB genes. Macromol Biosci 4:255–261
Weusthuis RH, Kessler B, Dielissen MPM, Witholt B, Eggink G (2002) Fermentative production of medium-chain-length poly(3-hydroxyalkanoate). In: Doi Y, Steinbüchel A (eds) Biopolymers (polyesters I). Wiley-VCH, Weinheim, pp 291–316
Yao YC, Zhan XY, Zou XH, Wang ZH, Xiong YC, Zhang J, Chen J, Chen GQ (2008) A specific drug targeting system based on polyhydroxyalkanoate granule binding protein PhaP fused with targeted cell ligands. Biomaterials 29:4823–4830
Yu HM, Shi Y, Yin J, Shen ZY, Yang SL (2003) Genetic strategy for solving chemical engineering problems in biochemical engineering. J Chem Technol Biotechnol 78:283–286
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Chen, GQ. (2010). Industrial Production of PHA. In: Chen, GQ. (eds) Plastics from Bacteria. Microbiology Monographs, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03287-5_6
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DOI: https://doi.org/10.1007/978-3-642-03287-5_6
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