Abstract
Androgenetic alopecia is a common, progressive, patterned loss of visible scalp hair. It causes psychological distress and negative effects on the quality of life. Adult levels of circulating androgens and functional intracellular receptors are essential prerequisites for the balding processes. Metabolism of circulating androgens, such as testosterone, to the more potent androgen, 5α-dihydrotestosterone, also appears necessary. Thisalso acts via the androgen receptor. The current model for androgen action in the hair follicle focusses on the mesenchyme-derived, regulatory dermal papilla at the base of the follicle. This responds to the circulating hormones and coordinates the rest of the follicular cells by altering the paracrine signals it produces. These may besoluble growth factors or extracellular matrix components. There is also a strong genetic aspect to the incidence of androgenetic alopecia. Since the response to androgens occurs within the follicle, it can differ. Androgen responses vary from stimulation (e.g. beard), no effect (e.g. eyelashes) to inhibition on areas of the scalp (androgenetic alopecia). This paradoxical difference underpins the successful transplant of unaffected follicles from non-balding regions into the androgen-sensitive, balding areas during corrective surgery for androgenetic alopecia.
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References
Ahmad W, Faiyaz ul Haque M, Brancolini V, Tsou HC, ul Haque S, Lam H, Aita VM, Owen J, deBlaquiere M, Frank J, Cserhalmi-Friedman PB, Leask A, McGrath JA, Peacocke M, Ahmad M, Ott J, Christiano AM (1998) Alopecia universalis associated with a mutation in the human hairless gene. Science 279:720–724
Ando Y, Yamaguchi Y, Hamada K, Yoshikawa K, Itami S (1999) Expression of mRNA for androgen receptor, 5α-reductase and 17β-hydroxysteroid dehydrogenase in human dermal papilla cells. Br J Dermatol 141:840–845
Asada Y, Sonoda T, Ojiro M, Kurata S, Sato T, Ezaki T, Takayasu S (2001) 5α-reductase type 2 is constitutively expressed in the dermal papilla and connective tissue sheath of the hair follicle in vivo but not during culture in vitro. J Clin Endocr Metab 86:2875–2880
Bellastella A, Criscuoco T, Mango A et al (1983) Circannual rhythms of LH, FSH, testosterone, prolactin and cortisol during puberty. Clin Endocrinol 19:453–459
Bergfeld WF (1955) Androgenetic alopecia: an autosomal dominant disorder. Am J Med 98:955–985
Birch MP, Messenger AG (2001) Genetic factors predispose to balding and non-balding in men. Eur J Dermatol 11:309–314
Brun-Falco O, Christophers E (1968) Hair root patterns in male pattern alopecia. In: Baccareda-Boy A, Moretti G, Fray JR (eds) Biopathology of pattern alopecia. Kargel, Basel, pp 141–145
Buiazzi M, Calandra P (1968) Testosterone elimination in female patients with acne, chronic alopecia and hirsutism. Ital Gen Rev Dermatol 8:241
Burton JL, Ben Halim MM, Meyrick G (1979) Male pattern alopecia and masculinity. Br J Dermatol 100:507–512
Camacho F, Randall VA, Price VH (eds) (2000) Hair and its disorders: biology, research and management. Martin Dunitz, London
Carey AH, Chan KL, Short F, White D, Williamson R, Franks S (1993) Evidence for a single gene effect causing polycystic ovaries and male pattern baldness. Clin Endocrinol 38(6):653–658
Cash TF (1992) The psychological effects of androgenetic alopecia in men. J Am Acad Dermatol 26:926–931
Cash TF (1993) Psychological effects of androgenetic alopecia on women: comparisons with balding men and with female control subjects. J Am Acad Dermatol 29: 568–575
Cela E, Robertson C, Rush K, Kousta E, White DM, Wilson H, Lyons G, Kingsley P, McCarthy MI, Franks S (2003) Prevalence of polycystic ovaries in women with androgenetic alopecia. Eur J Endocrinol 149:439–442
Choudhry R, Hodgins MB, Van der Kwast TH et al (1992) Localisation of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 133:467–475
Cipriani R, Ruzza G, Foresta C et al (1983) Sex hormone binding globulin and saliva testosterone levels in men with androgenetic alopecia. Br J Dermatol 109:249–252
Cobb JE, White SJ, Harrap SB, Ellis JA (2009) Androgen receptor copy number variation and androgenetic alopecia: a case-control study. PLoS One 4:e5081
Cotsarelis G, Sun T, Lavker R (1990) Label-retaining cells reside in the bulge area of the pilosebaceous unit; implications for follicular stem cells, hair cycle and skin carcinogenesis. Cell 61:1329–1337
Courtois M, Loussouarn G, Howseau S et al (1996) Periodicity in the growth and shedding of hair. Br J Dermatol 134:47–54
Covato F, Morreti G, Bertamino R (1968) In: Baccareda-Boy A, Moretti G, Fray JR (eds) Biopathology of pattern alopecia. Kargel, Basel, pp 191–199, 141
Croft NJ, Randall VA (2003) The antler of the red deer (Cervus elaphus): an androgen target organ. In: Van Neste D (ed) Hair science & technology. Brussels, pp 69–74
Cunha GR (2005) Endocrine actions of the prostate and benign prostatic hypertrophy. In: DeGroot LJ, Jameson J L (eds) Endocrinology, 5th edn. WB Saunders, Philadelphia, pp 3311–3324
Dawber R (2000) Update on minoxidil treatment of hair loss. In: Camacho F, Randall VA, Price VH (eds) Hair and its disorders: biology, research and management. Martin Dunitz, London, pp 169–173
Dawber RPP, de Berker D, Wojnarowska F (1998) Disorders of hair. In: Champion RH, Burton JL, Durns DA (eds) Rook/Wilkinson/Ebling textbook of dermatology, 6th edn. Blackwell Science, Oxford, pp 2869–2973
De Villez RL, Dunn J (1986) Female androgenetic alopecia. The 3α-17α androstanediol glucuronide/sex hormone binding globulin ratio as a possible marker for female pattern baldness. Arch Dermatol 122:1011–1014
Denmark-Wahnefried W, Lesko S, Conway MR et al (1997) Serum androgens: associations with prostate cancer risk and hair patterning. J Androl 18:495–500
Dry FW (1926) The coat of the mouse (Mus musculus). J Genet 16:32–35
Ebling FJG (1985) Age changes in cutaneous appendages. J Appl Cosmetol 3:243–250
Ebling FG, Hale PA, Randall VA (1991) Hormones and hair growth. In: Goldsmith LA (ed) Biochemistry and physiology of the skin, 2nd edn. Clarendon Press, Oxford, pp 660–690
El-Domyati M, Attia S, Saleh F, Abdel-Wahab H (2009) Androgenetic alopecia in males: a histopathological and ultrastructural study. J Cosmet Dermatol 8:83–91
Elliot K, Stephenson TJ, Messenger AG (1999) Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. J Invest Derm 113:873–877
Ellis JA, Harrap SB (2001) The genetics of androgenetic alopecia. Clin Dermatol 19:149–154
Ellis JA, Stebbing M, Harrap SB (1998) Genetic analysis of male pattern baldness and the 5alpha-reductase genes. J Invest Dermatol 110:849–853
Ellis JA, Stebbing M, Harrap SB (2001) Polymorphism of androgen receptor gene is associated with male pattern baldness. J Invest Dermatol 116:452–455
Ellis JA, Stebbing M, Harrap SB (2001) Male pattern baldness is not associated with established cardiovascular risk factors in the general population. Clin Sci 100:401–404
Franzoi SL, Anderson J, Frommelt S (1990) Individual differences in men’s perceptions of and reactions to thinning hair. J Soc Psychol 130:209–218
Fruzetti F (1997) Treatment of hirsutism: antiandrogen and 5α-reductase inhibitor therapy. In: Azziz R, Nestler JE, Dewailly D (eds) Androgen excess disorders in women. Lippincott-Raven, Philadelphia, pp 787–797
Futterweit W, Dunif Y, Yeh H-C, Kingsley P (1988) The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia. J Am Acad Dermatol 19:831
Georgala G, Papasotirion V, Stavropoulos P (1986) Serum testosterone and sex hormone binding levels in women with androgenetic alopecia. Acta Dermatol Venereol (Scand) 66:532
Giacometti L (1967) Facts, legends and myths about the scalp throughout history. Arch Dermatol 95:629–635
Giacometti L, Montagna W (1968) The nerve fibers in male pattern alopecia. In: Baccareda-Boy A, Moretti G, Fray JR (eds) Biopathology of pattern alopecia. Kargel, Basel, pp 208–216
Girman CJ, Rhodes T, Lilly FRW et al (1998) Effects of self-perceived hair loss in a community sample of men. Dermatology 197:223–229
Goodhart DB (1960) The evolutionary significance of human hair patterns and skin coloring. Adv Sci 17:53–59
Gormbey GJ, Stener E, Briskewitz RC et al (1992) The effect of finasteride in men with benign prostate hyperplasia. N Engl J Med 327:1185–1191
Ha SJ, Kim JS, Myung JW, Lee HJ, Kim JW (2003) Analysis of genetic polymorphisms of steroid 5 alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. J Dermatol Sci 31:135–141
Hamada K, Randall VA (2003) Balding scalp dermal papilla cells secrete a soluble factor(s) which delays the onset of anagen in mice in vivo. J Invest Derm Symp Proc 8:139
Hamada K, Randall VA (2006) Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness. B J Dermatol 154:609–618
Hamada K, Thornton MJ, Liang I et al (1996) Pubic and axillary dermal papilla cells do not produce 5α-dihydrotestosterone in culture. J Invest Dermatol 106:1017–1022
Hamilton JB (1942) Male hormone stimulation is a prerequisite and an incitant in common baldness. Am J Anat 71:451–480
Hamilton JB (1946) A secondary sexual character that develops in men but not in women upon aging of an organ present in both sexes. Anat Rec 94:466–467
Hamilton JB (1951) Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 53:708–728
Hamilton JB (1958) Age, sex and genetic factors in the regulation of hair growth in man: a comparison of Caucasian and Japanese populations. In: Montagna W, Ellis RA (eds) The biology of hair growth. Academic Press, New York, pp 399–433
Hamilton JB (1960) Effect of castration in adolescent and young adult males upon further changes in the proportions of bare and hairy scalp. J Clin Endocrinol Metabol 20:1309–1318
Handelsman DJ (2005) Androgens and androgen action. In: DeGroot LJ, Jameson J L (eds) Endocrinology, 5th edn. WB Saunders, Philadelphia, pp 3121–3138
Hayes VM, Saveri G, Padilla E, Morris H, Tilley W, Southey M, English D, Sutherland R, Hopper J, Boyle P, Giles G (2006) 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia. Int J Cancer 120:776–780
Hibberts NA, Randall VA (1996) Testosterone inhibits the capacity of cultured cells from human balding scalp dermal papilla cells to produce keratinocyte mitogenic factors. In: Van Neste DV, Randall VA (eds) Hair research for the next millennium. Elsevier, Amsterdam, pp 303–306
Hibberts NA, Messenger AG, Randall VA (1996) Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts. Biochem Biophys Res Commun 222:401–405
Hibberts NA, Howell AE, Randall VA (1998) Dermal papilla cells from human balding scalp hair follicles contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol 156:59–65
Hillmer AM, Kruse R, Macciardi F, Heyn U, Betz RC, Ruzicka T, Propping P, Nothen MM, Cichon S (2002) The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach. Br J Dermatol 146:601–608
Hillmer AM, Brockschmidt FF, Hanneken S, Eigelshoven S, Steffens M, Flaquer A, Herms S, Becker T, Kortüm AK, Nyholt DR, Zhao ZZ, Montgomery GW, Martin NG, Mülenisen TW, Alblas MA, Moebus S, Jöckel KH, Bröcker-Preuss M, Erbel R, Reinartz R, Betz RC, Cichon S, Propping P, Baur MP, Wienker TF, Kruse R, Nöthen MM (2008) Susceptibility variants for male pattern baldness on chromosome 20p11. Nat Genet 40:1279–1281
Hillmer AM, Freudenberg J, Myles S, Herms S, Tang K, Hughes DA, Brockschmidt FF, Ruan Y, Stonkeking M, Nöthen MM (2009) Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness. Hum Genet 126:255–264
Hoffmann R, Happle R (2000) Current understanding of androgenetic alopecia. Part II: clinical aspects and treatment. Eur J Dermatol 10:410–417
Ibanez L, Ong KK, Mongan N, Jaaskelainen J, Marcos MV, Hughes IA, De Zegher F, Dunger DB (2003) Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. J Clin Endocr Metab 88:3333–3338
Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S (2003) Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia. J Investig Dermatol Symp Proc 8:69–71
Itami S, Kurata S, Takayasu S (1990) 5α-Reductase activity in cultured human dermal papilla cells from beard compared with reticular dermal fibroblasts. J Invest Dermatol 94:150–152
Itami S, Kurata S, Takayasu S (1995) Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor I from dermal papilla cells. Biochem Biophys Res Commun 212:988–994
Itami S, Kurata S, Sonada T, Takayasu S (1995) Interactions between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen. Br J Dermatol 132:527–532
Jahoda CAB, Reynolds AJ (1996) Dermal-epidermal interactions; adult follicle-derived cell populations and hair growth. In: Whiting DA (ed) Dermatologic clinics 14: update on hair disorders. WB Saunders, Philadelphia, PA, pp 573–583
Kaufman KD, Olsen EA, Whiting D et al (1998) Finasteride in the treatment of men with androgenetic alopecia. J Am Acad Dermatol 39:578–589
Kaufman KD, Girman CJ, Round EM, Johnson-Levonas AO, Shah AK, Rotonda J (2008) Progression of hair loss in men with androgenetic alopecia (male pattern hair loss): long-term (5-year) controlled observational data in placebo-treated patients. Eur J Dermatol 18:407–411
Kaufman KD, Rotonda J, Shah AK, Meehan AG (2008) Long-term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss). Eur J Dermatol 18:400–406
Kitagawa T, Matsuda K, Inui S, Takenaka H, Katoh N, Itami S, Kishimoto S, Kawata M (2009) Keratinocyte growth inhibition through the modification of Wnt signalling by androgen in balding dermal papilla cells. J Clin Endrocrinol Metab 94:1288–1294
Kligman AG (1959) The human hair cycle. J Invest Dermatol 33:307–316
Kligman AM (1988) The comparative histopathology of male-pattern baldness and senescent baldness. Clin Dermatol 6:108–118
Konig A, Happle R, Tchitcherina E, Schaefer JR, Sokolowski P, Kohler W, Hoffmann R (2000) An X-linked gene involved in androgenetic alopecia: a lesson to be learned from adrenoleukodystrophy. Dermatology 200:213–218
Kuster W, Happle R (1984) The inheritance of common baldness: two B or not two B? J Am Acad Dermatol 11:921–926
Kwack MH, Sung YK, Chung EJ, Im SU, Ahn JS, Kim MK, Kim JC (2008) Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes. J Invest Dermatol 128: 262–269
Lambert G (1961) The conquest of baldness. The wonderful story of hair. Souvenir Press, London
Ludwig E (1968) The role of sexual hormones in pattern alopecia. In: Baccareda-Boy A, Moretti G, Fray JR (eds) Biopathology of pattern alopecia. Kargel, Basel, pp 50–60
Ludwig E (1977) Classification of the types of androgenetic alopecia (common baldness) arising in the female sex. Br J Dermatol 97:249–256
Maffei C, Fossati A, Reialdi F, Ruia E (1994) Personality disorders and psychopathologic symptoms in patients with androgenetic alopecia. Arch Dermatol 130:868–872
Maguire HC, Kligman AM (1963) Common baldness in women. Geriatrics 18:329–334
Marshall WA, Tanner JM (1969) Variations in pattern of pubertal change in girls. Arch Dis Child 44:291–303
Marshall WA, Tanner JM (1970) Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:13–23
McPhaul MJ (2004) Androgen receptors and androgen insensitivity syndromes. In: DeGroot LJ, Jameson JL (eds) Endocrinology, 5th edn. WB Saunders, Philadelphia
Merrick AE, Randall VA, Messenger AG, Thornton MJ Beard dermal sheath cells contain androgen receptors: implications for future inductions of human hair follicles. (np unpublished observations)
Messenger AG, Rundegren J (2004) Minoxidil: mechanisms of action on hair growth. Br J Dermatol 150:186–194
Miller JA, Darley CR, Karkavitsas K et al (1982) Low sex-hormone binding globulin levels in young women with diffuse hair loss. Br J Dermatol 106:331–336
Norwood OTT (1975) Male pattern baldness: classification and incidence. South Med J 68:1359–1370
Obana N, Chang C, Uno H (1997) Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the post-pubertal stump-tailed macaque. Endocrinology 138:356–361
O’Driscoll JB, Mamtora H, Higginson J, Pollock A, Kane J, Anderson DC (1994) A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenetic alopecia. Clin Endocrinol 4:231–236
Oliver RF, Jahoda CAB (1989) The dermal papilla and maintenance of hair growth. In: Rogers GE, Reis PR, Ward KA et al (eds) The biology of wool and hair. Chapman and Hall, London, pp 51–67
Olsen EA (1994) Androgenetic alopecia. In: Olsen EA (ed) Disorders of hair growth, diagnosis and treatment. McGraw-Hill, New York, pp 257–283
Olsen EA (ed) (2003) Disorders of hair growth. Diagnosis and treatment. McGraw-Hill, New York
Olsen EA, Dunlap FE, Funicella T, Koperski JA, Swinehart JM, Tschen EH, Trancik RJ (2002) A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 47:377–385
Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, Wilson T, Rittmaster RS, Dutasteride Alopecis Research Team (2006) The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. J Am Acad Dermatol 55:1014–1023
Orentreich N (1969) Scalp hair replacement in men. In: Montagna W, Dobson RL (eds) Advances in biology of skin. Vol 9: hair growth. Pergamon Press, Oxford, pp 99–108
Orentreich N, Durr NP (1982) Biology of scalp hair growth. Clin Plast Surg 9:197–205
Osbourn D (1916) Inheritance of baldness. J Hered 7:347–355
Pecoran V, Astore I, Barman JM (1968) The prenatal and postnatal hair cycles in men. In: Baccareda-Boy A, Moretti G, Fray JR (eds) Biopathology of pattern alopecia. Kargel, Basel, pp 29–38
Phillipou G, Kirke J (1981) Significance of steroid measurements in male pattern alopecia. Clin Exp Dermatol 6:53
Philpott MP (2000) The roles of growth factors in hair follicles: investigations using cultured hair follicles. In: Camacho F, Randall VA, Price VH (eds) Hair and its disorders: biology, research and management. Martin Dunitz, London, pp 103–113
Pitts RL (1987) Serum elevation of dehydroepiandrosterone sulfate associated with male pattern baldness in young men. J Am Acad Dermatol 16:571–573
Price VH, Roberts JL, Hordinsky M, Olsen EA, Savin R, Bergfeld W, Fiedler V, Lucky A, Whiting DA, Pappas F, Culbertson J, Kotey P, Meehan A, Waldstreicher J (2000) Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. J Am Acad Dermatol 43:768–776
Randall VA (1994) Androgens and human hair growth. Clin Endocrinol 40:439–457
Randall VA (2004) Androgens and hair: a biological paradox. In: Nieschlag E, Behre HM (eds) Testosterone: action, deficiency, substitution, 3rd edn. Cambridge University Press, Berlin, pp 207–231
Randall VA (2007) Hormonal regulation of hair follicles exhibits a biological paradox. In: Seminars cell & developmental biology: development of epidermal appendages. Headon D (ed), 18:274–285
Randall VA, Ebling EJG (1991) Seasonal changes in human hair growth. Br J Dermatol 124:146–151
Randall VA, Thornton MJ, Hamada K et al (1991) Androgens and the hair follicle: cultured human dermal papilla cells as a model system. Ann N Y Acad Sci 642:355–375
Randall VA, Thornton MJ, Messenger AG (1992) Cultured dermal papilla cells from androgen-dependent human follicles (e.g., beard) contain more androgen receptors than those from non-balding areas. J Endocrinol 133:141–147
Randall VA, Hibberts NA, Hamada K (1996) A comparison of the culture and growth of dermal papilla cells derived from normal and balding (androgenetic alopecia) scalp. Br J Dermatol 134:437–444
Randall VA, Hibberts NA, Thornton MJ, Hamada K, Merrick AE, Kato S, Jenner TJ, De Oliveria I, Messenger AG (2001) The hair follicle: a paradoxical androgen target organ. Horm Res 54:243–250
Randall VA, Hibberts NA, Thornton MJ, Merrick AE, Hamada K, Kato S, Jenner TJ, De Oliveira I, Messenger AG (2001) Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells? Eur J Dermatol 11:315–320
Randall VA, Jenner T, Hibberts N, De Oliveira I, Vafaee T (2008) Stem cell factor/c-kit signalling in normal and androgenetic alopecia hair follicles. J Endocrinol 197:1–14
Reinberg A, Lagoguey M, Chauffourinier JM, Cesselin F (1975) Circannual and circadian rhythms in plasma testosterone in five healthy young Parisian males. Acta Endocrinol 80:732–743
Reynolds AJ, Lawrence C, Cserhalmi-Friedman PB, Christiano AM, Jahoda CAB (1999) Trans-gender induction of hair follicles. Nature 402:33–34
Richards JB, Yuan X, Geller F, Waterworth D, Bataille V, Glass D, Song K, Waeber G, Vollenweider P, Aben KK, Kiemeney LA, Walters B, Soranzo N, Thorsteinsdottir U, Kong A, Rafnar T, Deloukas P, Sulem P, Stefansson H, Stefansson K, Spector TD, Mooser V (2008) Male pattern baldness susceptibility locus at 20p11. Nat Genet 40:1282–1284
Rushton DH, Ramsay ID, Norris MJ, Gilkes JJH (1991) Natural progression of male pattern baldness in young men. Clin Exp Dermatol 16:188–192
Saitoh M, Sakamoto M (1970) Human hair cycle. J Invest Dermatol 54:65–81
Schweikert H, Wilson JD (1974) Regulation of human hair growth by steroid hormones. I: testosterone metabolism in isolated hair. J Clin Endocr Metab 40:413–417
Setty LR (1970) Hair patterns of the scalp of white and negro males. Am J Phys Anthropol 33:49–55
Shapiro J, Kaufman KD (2003) Use of finasteride in the treatment of men with androgenetic alopecia (male pattern hair loss). J Invest Derm Symp Proc 8:20–23
Shapiro J, Price VH (1998) Hair regrowth: therapeutic agents: dermatologic therapy. Dermatol Clin 16:341–356
Shorter K, Farjo NP, Picksley SM, Randall VA (2008) Human hair follicles contain two forms of ATP sensitive potassium channels, only one of which is sensitive to minoxidil. FASEB J 22:1725–1736
Smals AGH, Kloppenberg PWC, Benrad THJ (1976) Circannual cycle in plasma testosterone levels in man. J Clin Endocrinol Metabol 42:979–982
Sonada T, Asada Y, Kurata S, Takayasu S (1999) The mRNA for protease nexin-1 is expressed in human dermal papilla cells and its level is affected by androgen. J Invest Derm 113:308–313
Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, Ostrander EA (1997) Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res 57:1194–1198
Stenn K, Parimoo S, Prouty S (1998) Growth of the hair follicle: a cycling and regenerating biological system. In: Chuong CM (ed) Molecular basis of epithelial appendage morphogenesis. Laudes, Austin
Stickler JH, Algin BG (1997) Androgen excess and hair loss in women. In: Azziz R, Nestler JE, Dewailly D (eds) Androgen excess disorders. Lippincot-Raven, New York, pp 141–147
Takashima I, Iju M, Sudo M (1981) Alopecia androgenetica – its incidence in Japanese and associated conditions. In: Orfanos CE, Montagna W, Stuttgen G (eds) Hair research status and future aspects. Springer, New York, pp 287–293
Terry RL, Davis JS (1976) Components of facial attractiveness. Percept Mot Skills 42:918
Thornton MJ, Liang I, Hamada K et al (1993) Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells. Clin Endocrinol 39:633–639
Thornton MJ, Hamada K, Messenger AG, Randall VA (1998) Beard, but not scalp, dermal papilla cells secrete autocrine growth factors in response to testosterone in vitro. J Invest Dermatol 111:727–732
Unger WP (2000) Innovations in hair transplanting: progress versus promotion. Adv Dermatol 16:427–450
Uno H, Imamura K, Pan H (2000) Androgenetic alopecia in the stump-tailed macaque: an important model for investigating the pathology and antiandrogenic therapy of male-pattern baldness. In: Camacho F, Randall VA, Price VH (eds) Hair and its disorders: biology, research and management. Martin Dunitz, London, pp 137–151
Van der Dank J, Passchier J, Knegt-Junk C et al (1991) Psychological characteristics of women with androgenetic alopecia: a controlled study. Br J Dermatol 125: 248–252
Venning VA, Dawber R (1988) Patterned androgenetic alopecia. J Am Acad Dermatol 18:1073–1078
Vexiau P, Chaspoux C, Boudou P, Fiet J, Jouanique C, Hardy N, Reygagne P (2002) Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial. Br J Dermatol 146:992–999
Wells PA, Willmoth T, Russell RJH (1995) Does fortune favor the bald? Psychological correlates of hair loss in males. Br J Psychol 86:337–344
Whiting DA (1993) Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia. J Am Acad Dermatol 28: 755–763
Whiting DA, Olsen EA, Savin R, Halper L, Rodgers A, Wang L, Hustad C, Palmisano J, Male Pattern Hair Loss Study Group (2003) Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. Eur J Dermatol 13:150–160
Wilson JD, Griffin JE, Russell DW (1993) Steroid 5α-reductase 2 deficiency. Endocr Rev 14:577–593
Winter JSD, Faiman C (1972) Pituitary-gonadal relations in male children and adolescents. Pediatr Res 6: 125–135
Winter JSD, Faiman C (1973) Pituitary-gonadal relations in female children and adolescents. Pediatr Res 7: 948–953
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Randall, V.A. (2010). Molecular Basis of Androgenetic Alopecia. In: Trüeb, R., Tobin, D. (eds) Aging Hair. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02636-2_2
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