Skip to main content

The Conventional Gastric Bypass

  • Chapter
Principles of Metabolic Surgery

Abstract

After the Second World War during the 1950's, subtotal gastrectomy with the Billroth II reconstruction was the surgical treatment of choice for peptic ulcer disease. Post-operative weight loss and early satiety were frequently observed in these patients, and these observations led Mason in 1966 to begin restrictive bariatric surgery by introducing the gastric bypass procedure. The initial technique involved a horizontal proximal gastric division of 10% of the stomach with a gastric pouch of approximately 100–150 ml. Mason reconstructed the alimentary passage with a short afferent biliopancreatic limb and a 12-mm in diameter end-side gastrojejunal anastomosis, and then left the residual distal stomach in place. Later on, Mason improved early satiety and postoperative weight loss by reducing the gastric pouch to 50 ml. Further improvements and modifications were made by Ward Griffen, who introduced the retrocolic Roux-en-Y loop reconstruction. He excluded the biliopancreatic juices and thereby reduced the risk of gastrojejunal fistulas. Griffen and Alden modified this technique with a simple division of the stomach without performing a complete transection. Jose Torres and Clemente Oca introduced the prototype of the modern gastric bypass procedure. They created the gastric pouch on the lesser curvature, 4 cm distal to the cardia, and separated the gastric pouch from the rest of the stomach. They created a gastric pouch with 35 ml volume. The jejunum was dissected 45 cm from the ligament of Treitz, and the gastroentero-anastomosis (GEA) was performed with a 21-mm circular stapler, with the anvil inserted through a gastrostomy in the upper part of the anterior wall of the pouch. The end-loop with the end-side anastomosis was created at 90 cm. The first laparoscopic gastric bypass was performed by Wittgrove in 1994. Later, several technical variations were introduced with sometimes mechanical, sometimes manual, gastroenteroanastomosis. The stomach is always transected, and the gastric pouch is usually vertical and on the lesser gastric curvature. The alimentary, common, and biliopancreatic limbs are of variable length and depend on the intention to enhance either the restrictive or the malabsorptive potency of the procedure.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Deitel M (2008) The change in the dumping syndrome concept. Obes Surg 18:1622–1624

    Article  PubMed  Google Scholar 

  2. Ernst B, Thurnheer M, Wilms B, Schultes B (2009) Differential Changes in dietary habits after gastric bypass versus gastric banding operations. Obes Surg 19:274–280

    Article  PubMed  Google Scholar 

  3. Cummings DE, Weigle DS, Frayo RS et al (2002) Plasma ghrelin levels after diet induced weight loss or gastric bypass surgery. N Engl J Med 346:1623–1630

    Article  PubMed  Google Scholar 

  4. Holst JJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87:1409–1439

    Article  PubMed  CAS  Google Scholar 

  5. Kreymann B, Williams G, Ghatei MA et al (1987) Glucagon peptide- 1: a physiological incretin in man. Lancet 2:1300–1304

    Article  PubMed  CAS  Google Scholar 

  6. Buteau J, Roduit R, Susini S et al (1999) Glucagon like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1) cells. Diabetologia 42:856–864

    Article  PubMed  CAS  Google Scholar 

  7. Fehmann HC, Habener JF (1992) Insulinotropic hormone glucagon- like peptide-1 stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130:159–166

    Article  PubMed  CAS  Google Scholar 

  8. Zander M, Madsbad S, Madsen JL et al (2002) Effect of 6-week course of glucagon like peptide-1 on glycaemic control, insulin sensitivity, and beta cell function in type 2 diabetes: a parallelgroup study. Lancet 359:824–830

    Article  PubMed  CAS  Google Scholar 

  9. Meier JJ, Gallwitz B, Salmen S et al (2003) Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagons like peptide-1 in patients with type 2 diabetes. J Clin Endocrinol Metab 88:2719–2725

    Article  PubMed  CAS  Google Scholar 

  10. Hvidberg A, Nielsen MT, Hilsted J et al (1994) Effect of glucagon like peptide-1 on hepatic glucose production in healthy man. Metabolism 43:104–108

    Article  PubMed  CAS  Google Scholar 

  11. Borg CM, le Roux CW, Ghatei MA et al (2006) Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg 93:210–215

    Article  PubMed  CAS  Google Scholar 

  12. Morinigo R, Lacy AM, Casamitjana R et al (2006) GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese subjects. Obes Surg 16:1594–1601

    Article  PubMed  Google Scholar 

  13. Laferrere B, Teixeira J, McGinty J et al (2008) Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 93:2479–2485

    Article  PubMed  CAS  Google Scholar 

  14. le Roux CW, Welbourn R, Werling M et al (2007) Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 246:780–785

    Article  PubMed  Google Scholar 

  15. Laferrere B, Tran , Egger JR et al (2007) The increase in GLP-1 levels and incretin effect after Roux-en-Y gastric bypass surgery persists up to 1 year in patients with type 2 diabetes mellitus. The Obesity Society Annual Meeting, October 20, 2007; New Orleans, Nature Publishing Group, p A7

    Google Scholar 

  16. Laferrere B, Heshka S, Wang K et al (2007) Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes 30:1709–1716

    Article  CAS  Google Scholar 

  17. Rodieux F, Giusti V, Dalessio DA et al (2008) Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Obesity (Silver Spring) 16:298–305

    Article  CAS  Google Scholar 

  18. Vrang N, Madsen AN, Tang-Christensen M et al (2006) PYY (3–36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 291:R367–375

    Article  PubMed  CAS  Google Scholar 

  19. Sun Y, Asnicar M, Saha PK et al (2006) Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice Cell Metab 3:379–386

    Article  PubMed  CAS  Google Scholar 

  20. Bóse M, Olivan B, Teixeira J, Pi-Sunyer FX, Laferrere B (2009) Do incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: what is the evidence? Obes Surg 19:217–229

    Article  PubMed  Google Scholar 

  21. Polyzogopoulou EV, Kalfarentzos F, Vagenakis AG et al (2003) Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. Diabetes 52:1098–1103

    Article  PubMed  CAS  Google Scholar 

  22. Wickremesekera K, Miller G, Naotunne TD et al (2005) Loss of insulin resistance after Roux-en-Y gastric bypass surgery: a time course study. Obes Surg 15:474–481

    Article  PubMed  Google Scholar 

  23. Maggs D, MacDonald I, Nauck MA (2008) Glucose homeostasis and the gastrointestinal tract: insights into the treatment of diabetes. Diabetes Obes Metab 10:18–33

    PubMed  CAS  Google Scholar 

  24. Morinigo R, Moize V, Musri M et al (2006) Glucagon-like peptide- 1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 91:1735–1740

    Article  PubMed  CAS  Google Scholar 

  25. le Roux CW, Aylwin SJ, Battwerham RL et al (2006) Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 243:108–114

    Article  PubMed  Google Scholar 

  26. Batterham RL, Cowley MA, Small CJ et al (2003) Inhibition of food intake in obese subjects by peptide YY3–36. N Engl J Med 349:941–948

    Article  PubMed  CAS  Google Scholar 

  27. Morinigo R, Vidal J, Lacy AM et al (2008) Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects. Ann Surg 247:270–275

    Article  PubMed  Google Scholar 

  28. Jequier E (2002) Leptin signalling, adiposity, energy balance. Ann N Y Acad Sci 967:79–88

    Google Scholar 

  29. Korner, Bessler M, Cirilo LJ et al (2005) Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 90:359–365

    Article  PubMed  CAS  Google Scholar 

  30. Faraj M, Havel PJ, Phelis S et al (2003) Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 88:1594–1602

    Article  PubMed  CAS  Google Scholar 

  31. Dhabuwala A, Cannan RJ, Stubbs RS (2000) Improvement in co-morbidities following weight loss from gastric bypass surgery. Obes Surg 10:428–435

    Article  PubMed  CAS  Google Scholar 

  32. MacLean LD, Rhode BM, Nohr CW (2000) Late outcome of isolated gastric bypass. Ann Surg 231:524–528

    Article  PubMed  CAS  Google Scholar 

  33. Oh CH, Kim HJ, Oh S (1997) Weight loss following transected gastric bypass with proximal Roux-en-Y. Obes Surg 7:142–147

    Article  PubMed  CAS  Google Scholar 

  34. Smith SC, Goodman GN, Edwards CB (1995) Roux-en-Y gastric bypass: a 7-year retrospective review of 3855 patients. Obes Surg 5:314–318

    Article  PubMed  Google Scholar 

  35. Pories WJ, MacDonald KG Jr., Morgan EJ et al (1992) Surgical treatment of obesity and its effect on diabetes: 10-y follow-up. Am J Clin Nutr 55:582S–585S

    PubMed  CAS  Google Scholar 

  36. Adams TD, Gress RE, Smith SC, Halverson RC et al (2007) Longterm mortality after gastric bypass surgery. N Engl J Med 357:753–761

    Article  PubMed  CAS  Google Scholar 

  37. Sjöström L, Lindroos AK, Peltonen M, Torgerson J et al (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351:2683–2693

    Article  PubMed  Google Scholar 

  38. White S, Brooks E, Jurikova L, Stubbs RS (2005) Long-term outcomes after gastric bypass. Obes Surg 15:155–163

    Article  PubMed  Google Scholar 

  39. Deitel M (1998) Overview of operations for morbid obesity. World J Surg 22:913–918

    Article  PubMed  CAS  Google Scholar 

  40. Deitel M, Shahi B (1992) Morbid obesity: selection of patients for surgery. J Am Coll Nutr 11:457

    PubMed  CAS  Google Scholar 

  41. Shauer P, Ikramuddin S, Gourash W, Ramanathan R, Luketich J (2000) Outcomes after laparoscopic Roux-en-Y gastric bypass for morbid obesity. Ann Surg 232:515–529

    Article  Google Scholar 

  42. Lujan JA, Hernandez Q, Frutos MD, Valero G, Cuenca JR, Parrilla P (2002) Laparoscopic gastric bypass in the treatment of morbid obesity. Surg Endosc 16:1658–1662

    Article  PubMed  CAS  Google Scholar 

  43. Nguyen NT, Goldman C, Rosenquist J, Arango A, Cole CJ, Lee SJ, Wolfe BM (2001) Laparoscopic versus open gastric bypass: A randomized study of outcomes, quality of life, and costs. Ann Surg 234:279–291

    Article  PubMed  CAS  Google Scholar 

  44. Higa KD, Boone KB, Ho T (2000) Complications of the laparoscopic Roux-en-Y gastric bypass: 1040 patients: what have we learned? Obes Surg 10:509–613

    Article  PubMed  CAS  Google Scholar 

  45. DeMaria EJ, Sugerman HJ, Kellum JM, Meador JG, Wolfe LG (2002) Results of 281 consecutive total laparoscopic Roux-en-Y-gastric bypasses to treat morbid obesity. Ann Surg 235:640–645

    Article  PubMed  Google Scholar 

  46. Nguyen NT, Tivers R, Wolfe BM (2003) Early gastrointestinal hemorrhage after laparoscopic gastric bypass. Obes Surg 13:62–65

    Article  PubMed  Google Scholar 

  47. Bakhos C, Alkhoury F, Kyriakides T, Reinhold R, Nadzam G (2009) Early postoperative hemorrhage after open and laparoscopic Roux-en-Y gastric bypass. Obes Surg 19:153–157

    Article  PubMed  Google Scholar 

  48. Allieta R, Fabozzi M, Loffredo A, Parini U (2007) Laparoscopic Roux-en-Y gastric bypass. In: Parini U, Nebiolo PE (eds) Bariatric surgery, 2nd ed. Musumeci Editore

    Google Scholar 

  49. Csendes A, Burgos AM, Altuve J, Bonacic S (2009) Incidence of marginal ulcer 1 month and 1 to 2 years after gastric bypass: A prospective consecutive endoscopic evaluation of 442 patients with morbid obesity. Obes Surg 19:135–138

    Article  PubMed  Google Scholar 

  50. Mejia-Rivas MA, Herrera-Lopez A, Hernandez-Alleros J, Herrera MF, Valdovinos MA (2008) Gastroesophageal reflux disease in morbid obesity: the effect of Roux-en-Y gastric bypass. Obes Surg 18:1217–1224

    Article  PubMed  Google Scholar 

  51. Parkes E (2006) Nutritional management of patients after bariatric surgery. Am J Med Sci 331:207–213

    Article  PubMed  Google Scholar 

  52. Vargas-Ruiz AG, Hernandez-Rivera G, Herrera MF (2008) Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. Obes Surg 18:288–293

    Article  PubMed  Google Scholar 

  53. Borlin RE, Gorman JH, Gorman RC et al (1998) Prophylactic iron supplementation after Roux-en-Y gastric bypass: a prospective, double-blind, randomized study. Arch Surg 122:740–744

    Google Scholar 

  54. Decker GA, Swain JM, Crowell MD (2007) Gastrointestinal and nutritional complications after bariatric surgery. Am J Gastroenterol 102:1–10

    Article  Google Scholar 

  55. Mahdy T, Atia S, Farid M, Adulatif A (2008) 1Effect of Roux-en-Y gastric bypass on bone metabolism in patients with morbid obesity: Mansoura experiences Obes Surg 8:1526–1531

    Article  Google Scholar 

  56. Halverson, JD, Zuckerman GR, Koheler RE et al (1981) Gastric bypass for morbid obesity. A medical-surgical assessment. Ann Surg 194:152–160 57. Amaral JF, Thompson WR, Caldwell MD et al (1985) Prospective hematologic evaluation of gastric exclusion surgery for morbid obesity. Ann Surg 201:186–193

    Google Scholar 

  57. Mallory GN, Macgregor AM (1991) Folate status following gastric bypass surgery (the great folate mystery). Obes Surg 1:69–72

    Article  PubMed  Google Scholar 

  58. Simard B, Turcette H, Marceau P et al (2004) Asthma and sleep apnea in patients with morbid obesity: outcome of bariatric surgery. Obes Surg 14:1381–1388

    Article  PubMed  Google Scholar 

  59. Arterburn D, Schauer DP, Wise RE, Gersin KS, Fischer DR, Selwyn CA, Risman A, Tsevat J (2009) Change in predicted 10-year cardiovascular risk following laparoscopic Roux-en-Y gastric bypass surgery. Obes Surg 19:184–189

    Article  PubMed  Google Scholar 

  60. Carson L, Ruddy ME, Duff AE, Holmes NJ, Cody RP, Brolin RE (1994) The effect of gastric bypass surgery on hypertension in morbidly obese patients. Arch Intern Med 154:193–200

    Article  PubMed  CAS  Google Scholar 

  61. Jones KB (1992) The effect of gastric bypass on cholesterol, HDL, and the risk of coronary heart disease. Obes Surg 2:83–85

    Article  PubMed  Google Scholar 

  62. Buchwald H, Avidor Y, Braunwald E et al (2004) Bariatric surgery: a systemic review and meta-analysis. JAMA 292:1724–1737

    Article  PubMed  CAS  Google Scholar 

  63. Mottin CC, Padoin AV, Schroer CE, Barancelli FT, Glock L, Repetto G (2008) Behavior of type 2 diabetes mellitus in morbid obese patients submitted to gastric bypass. Obes Surg 18:179–181

    Article  PubMed  Google Scholar 

  64. Alexandrides TK, Skroubis G, Kalfarentzos F (2007) Resolution of diabetes mellitus and metabolic syndrome following Roux-en-Y gastric bypass and variant of biliopancreatic diversion in patients with morbid obesity. Obes Surg 17:176–184

    Article  PubMed  Google Scholar 

  65. Scheen AJ, Luyckx FH, Lefebvre PJ (1998) The place of bariatric surgery in the management of the obese type 2 diabetic patient. Int Diab Monitor 10:1–7

    Google Scholar 

  66. Foley EF, Benotti PN, Borlase BC et al (1992) Impact of gastricrestrictive surgery on hypertension in the morbidly obese. Am J Surg 163:294–297

    Article  PubMed  CAS  Google Scholar 

  67. Cowan GS jr, Buffington CK (1998) Significant changes in blood pressure, glucose, and lipids with gastric bypass surgery. World J Surg 22:987–992

    Article  PubMed  Google Scholar 

  68. Gleysteen JJ (1992) Results of surgery: long-term effects on hyperlipidemia. Am J Clin Nutr 55:591S–593S

    PubMed  CAS  Google Scholar 

  69. Reaven GM, Lithell H, Landsberg L (1996) Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med 334:374–381

    Article  PubMed  CAS  Google Scholar 

  70. Ferrannini E, Buzzigoli G, Bonadonna R et al (1987) Insulin resistance in essential hypertension N Engl J Med 317:350–357

    Article  PubMed  CAS  Google Scholar 

  71. DeFronzo RA, Ferrannini E (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173–194

    Article  PubMed  CAS  Google Scholar 

  72. Stubbs RS, Wickremesekera SK (2001) Insulin resistance and type 2 diabetes: time for a new hypothesis. NZ Med J 114:239–240

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Thomusch, O., Karcz, W.K. (2012). The Conventional Gastric Bypass. In: Karcz, W.K., Thomusch, O. (eds) Principles of Metabolic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02411-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-02411-5_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02410-8

  • Online ISBN: 978-3-642-02411-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics