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Molecular Mechanisms of Campylobacter Infection

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Molecular Mechanisms of Bacterial Infection via the Gut

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 337))

Abstract

Campylobacter jejuni is the principal bacterial foodborne pathogen. A major challenge still is to identify the virulence strategies exploited by C. jejuni. Recent genomics, proteomics, and metabolomics approaches indicate that C. jejuni displays extensive inter- and intrastrain variation. The diverse behavior enables bacterial adaptation to different environmental conditions and directs interactions with the gut mucosa. Here, we report recent progress in understanding the molecular mechanisms and functional consequences of the phenotype diversity. The results suggest that C. jejuni actively penetrates the intestinal mucus layer, secretes proteins mainly via its flagellar apparatus, is engulfed by intestinal cells, and can disrupt the integrity of the epithelial lining. C. jejuni stimulates the proinflammatory pathway and the production of a large repertoire of cytokines, chemokines, and innate effector molecules. Novel experimental infection models suggest that the activation of the innate immune response is important for the development of intestinal pathology.

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Acknowledgements

The authors are financially supported by grants from the Netherlands Organization of Health Research and Development (ZonMW-grant 9120-6150 and VIDI-grant 917.66.330).

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  1. Department of Infectious Diseases & Immunology, Utrecht University, Yalelaan 1, 3584, CL, Utrecht, The Netherlands

    Jos P. M. van Putten, Lieke B. van Alphen, Marc M. S. M. Wösten & Marcel R. de Zoete

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  1. Institute of Medical Science, University of Tokyo, Shirokanedai 1, Tokyo, 108-8639, Japan

    Chihiro Sasakawa

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van Putten, J.P.M., van Alphen, L.B., Wösten, M.M.S.M., de Zoete, M.R. (2009). Molecular Mechanisms of Campylobacter Infection. In: Sasakawa, C. (eds) Molecular Mechanisms of Bacterial Infection via the Gut. Current Topics in Microbiology and Immunology, vol 337. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01846-6_7

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