Abstract
The neighbour-joining method reconstructs phylogenies by iteratively joining pairs of nodes until a single node remains. The criterion for which pair of nodes to merge is based on both the distance between the pair and the average distance to the rest of the nodes. In this paper, we present a new search strategy for the optimisation criteria used for selecting the next pair to merge and we show empirically that the new search strategy is superior to other state-of-the-art neighbour-joining implementations.
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References
Elias, I., Lagergren, J.: Fast neighbour joining. In: Caires, L., Italiano, G.F., Monteiro, L., Palamidessi, C., Yung, M. (eds.) ICALP 2005. LNCS, vol. 3580, pp. 1263–1274. Springer, Heidelberg (2005)
Elias, I., Lagergren, J.: Fast computation of distance estimators. BMC Bioinformatics 8, 89 (2007)
Evans, J., Sheneman, L., Foster, J.A.: Relaxed neighbor joining: A fast distance-based phylogenetic tree construction method. Journal of Molecular Evolution 62(6), 785–792 (2006)
Finn, R.D., Mistry, J., Schuster-Böckler, B., Griffiths-Jones, S., Hollich, V., Lassmann, T., Moxon, S., Marshall, M., Khanna, A., Durbin, R., Eddy, S.R., Sonnhammer, E.L.L., Bateman, A.: Pfam: Clans, web tools and services. Nucleic Acids Research, Database Issue 34, D247–D251 (2006)
Howe, K., Bateman, A., Durbin, R.: QuickTree: Building huge neighbour-joining trees of protein sequences. Bioinformatics 18(11), 1546–1547 (2002)
Mailund, T., Brodal, G.S., Fagerberg, R., Pedersen, C.N.S., Philips, D.: Recrafting the neighbor-joining method. BMC Bioinformatics 7(29) (2006)
Mailund, T., Pedersen, C.N.S.: QuickJoin – fast neighbour-joining tree reconstruction. Bioinformatics 20, 3261–3262 (2004)
Saitou, N., Nei, M.: The neighbor-joining method: A new method for reconstructing phylogenetic trees. Molecular Biology and Evolution 4, 406–425 (1987)
Sanderson, M.L.: Inferring absolute rates of molecular evolution and divergence times in the absence of molecular clock. Bioinformatics 19, 301–302 (2003)
Sheneman, L., Evans, J., Foster, J.A.: Clearcut: A fast implementation of relaxed neighbor-joining. Bioinformatics 22(22), 2823–2824 (2006)
Studier, J.A., Kepler, K.J.: A note on the neighbour-joining method of Saitou and Nei. Molecular Biology and Evolution 5, 729–731 (1988)
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Simonsen, M., Mailund, T., Pedersen, C.N.S. (2008). Rapid Neighbour-Joining. In: Crandall, K.A., Lagergren, J. (eds) Algorithms in Bioinformatics. WABI 2008. Lecture Notes in Computer Science(), vol 5251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87361-7_10
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DOI: https://doi.org/10.1007/978-3-540-87361-7_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-87360-0
Online ISBN: 978-3-540-87361-7
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