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Transient Receptor Potential Channels on Sensory Nerves

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Sensory Nerves

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 194))

Abstract

The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of “thermoTRPs” TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 in nociception. In concert, through the efforts of many industrial and academic teams, a number of agonists and antagonists of these channels have been discovered, paving the way for a better understanding of sensory biology and, potentially, for novel treatments for diseases.

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Abbreviations

2-APB:

2-Aminoethoxydiphenyl borate

CFA:

Complete Freund's adjuvant

DRG:

Dorsal root ganglion

PIP2 :

Phosphatidylinositol 4,5-bisphosphate

RTX:

Resiniferatoxin

TRP:

Transient receptor potential

TRPA1:

Transient receptor potential ankyrin subfamily, member 1

TRPM8:

Transient receptor potential melastatin subfamily, member 8

TRPV1:

Transient receptor potential vanilloid subfamily, member 1

TRPV2:

Transient receptor potential vanilloid subfamily, member 2

TRPV3:

Transient receptor potential vanilloid subfamily, member 3

TRPV4:

Transient receptor potential vanilloid subfamily, member 4

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Authors and Affiliations

  1. Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, West Point, Philadelphia, USA

    S.R. Eid

  2. Department of Biochemistry and Molecular Biology, Neurogen Corporation, 35 N.E. Industrial Road, Branford, CT, USA

    D.N. Cortright

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  1. S.R. Eid
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  2. D.N. Cortright
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Correspondence to S.R. Eid .

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Editors and Affiliations

  1. Dept. Medicine, Johns Hopkins Asthma & Allergy Center, Hopkins Bayview Circle 5501, Baltimore, 21224, U.S.A.

    Brendan J. Canning

  2. School of Biomedical & Health Sciences, King's College London, Guy's Campus, London, SE1 9RT, United Kingdom

    Domenico Spina

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© 2009 Springer-Verlag Berlin Heidelberg

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Eid, S., Cortright, D. (2009). Transient Receptor Potential Channels on Sensory Nerves. In: Canning, B., Spina, D. (eds) Sensory Nerves. Handbook of Experimental Pharmacology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79090-7_8

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