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Disorders at the Testicular Level

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Andrology

Abstract

Bilateral congenital anorchia occurs only in one of 20,000 males. Unilateral congenital anorchia is about four times as frequent. Vascular and genetic disturbances, intrauterine infections, trauma or terato-genic factors are discussed as causes for the loss of one or both testes. A suspected abnormality in the sex-determining region of the Y chromosome, the SRY gene, could not be confirmed so far (Lobacarro et al. 1993). Nor could mutations in other genes responsible for testicular development and descent be clearly identified to date (Vinci et al. 2004; Philibert et al. 2007). Currently intrauterine torsion is favored as the most probable cause.

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  1. Centre for Reproductive Medicine and Andrology of the University, Domagkstr. 11, Mönster, 48149, Germany

    Eberhard Nieschlag & Sabine Kliesch

  2. Centre for Reproductive Medicine and Andrology of the University, Ernst-Grube-Str. 40, Halle/Saale, 06120, Germany

    Hermann M. Behre

  3. Institute of Human Genetics of the University, Vesaliusweg 12-14, Münster, 48149, Germany

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  4. Herbert-Lewin-Straße 9, Köln, 50931, Germany

    Dieter Meschede

  5. University Women's Hospital Lübeck, Ratzeburger Allee 160, Lübeck, 23538, Germany

    Axel Kamischke

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Nieschlag, E., Behre, H.M., Wieacker, P., Meschede, D., Kamischke, A., Kliesch, S. (2010). Disorders at the Testicular Level. In: Nieschlag, E., Behre, H.M., Nieschlag, S. (eds) Andrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78355-8_13

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  • DOI: https://doi.org/10.1007/978-3-540-78355-8_13

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