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Messenger RNA 3′ End Formation in Plants

  • Chapter
Nuclear pre-mRNA Processing in Plants

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 326))

Messenger RNA 3′ end formation is an integral step in the process that gives rise to mature, translated messenger RNAs in eukaryotes. With this step, a premessenger RNA is processed and polyadenylated, giving rise to a mature mRNA bearing the characteristic poly(A) tract. The poly(A) tract is a fundamental feature of mRNAs, participating in the process of translation initiation and being the focus of control mechanisms that define the lifetime of mRNAs. Thus messenger RNA 3′ end formation impacts two steps in mRNA biogenesis and function. Moreover, mRNA 3′ end formation is something of a bridge that integrates numerous other steps in mRNA biogenesis and function. While the process is essential for the expression of most genes, it is also one that is subject to various forms of regulation, such that both quantitative and qualitative aspects of gene expression may be modulated via the polyadenylation complex. In this review, the current status of understanding of mRNA 3′ end formation in plants is discussed. In particular, the nature of mRNA 3′ ends in plants is reviewed, as are recent studies that are beginning to yield insight into the functioning and regulation of plant polyadenylation factor subunits.

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Abbreviations

CPSF:

Cleavage and polyadenylation specificity factor

CstF:

Cleavage stimulatory factor

CFIm:

Mammalian cleavage factor I

CFIy:

Yeast cleavage factor

CPF:

Yeast cleavage and polyadenylation factor

PAP:

Poly(A) polymerase

UTR:

Untranslated region

nts:

Nucleotides

FUE:

Far upstream element

NUE:

Near upstream element

CS:

Cleavage site

CE:

Cleavage element

ETR1:

Ethylene receptor 1

TIR:

Toll/interleukin-1 receptor homology domain

Fip:

Factor interacting with poly(A) polymerase

FLAG:

So-called FLAG epitope

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Authors and Affiliations

  1. Department of Plant and Soil Sciences, University of Kentucky, 301A Plant Science Building, Lexington, KY, 40546-0312, USA

    A. G. Hunt

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  1. A. G. Hunt
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  1. Department of Biology and Program in Molecular Plant Biology, Colorado State University, Fort Collins, CO, 80523, USA

    Anireddy S. N. Reddy

  2. Department of Microbiology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

    Maxim Golovkin

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Hunt, A.G. (2008). Messenger RNA 3′ End Formation in Plants. In: Reddy, A.S.N., Golovkin, M. (eds) Nuclear pre-mRNA Processing in Plants. Current Topics in Microbiology and Immunology, vol 326. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76776-3_9

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