Abstract
Assessment of dopamine and serotonin metabolites in cerebrospinal fluid (CSF) can provide a valuable insight into the integrity of the metabolism of these neurotransmitters. Using HPLC with electrochemical detection, homovanillic acid, 5-hydroxyindoleacetic acid and 3-methyldopa are quantified and the values obtained compared to appropriate age related reference intervals. Appreciation of the CSF biochemical profile associated with tyrosine hydroxylase deficiency, aromatic amino acid decarboxylase deficiency, pterin disorders and inborn errors of vitamin B6 metabolism allow diagnoses to be made and appropriate treatment regimes instigated.
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© 2008 Springer-Verlag Berlin Heidelberg
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Heales, S. (2008). Biogenic Amines. In: Blau, N., Duran, M., Gibson, K. (eds) Laboratory Guide to the Methods in Biochemical Genetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76698-8_29
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DOI: https://doi.org/10.1007/978-3-540-76698-8_29
Publisher Name: Springer, Berlin, Heidelberg
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