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Obstructive Uropathy

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Pediatric Nephrology

Abstract

Urinary tract obstruction initiates a complex sequence of events resulting in impaired renal function (1), and obstructive uropathy is a major cause of renal impairment in infants and children. In early development, chronic urinary tract obstruction impairs renal growth and development. In view of its clinical importance, the pathophysiology of urinary tract obstruction has been studied intensively, leading to the development of numerous experimental models, including complete and partial ureteral obstruction, unilateral and bilateral obstruction, and acute and chronic obstruction. Most experiments have been performed in adult animals: therefore comparisons with obstructive uropathy in human infants and children must be made with caution.

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Acknowledgments

National Institutes of Health grants DK40558, DK44756, DK52612, and DK45179 supported original studies by Dr. Chevalier.

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Authors and Affiliations

  1. University of Virginia, Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, USA

    Robert L. Chevalier

  2. Department of Urology, University of Virginia Health System, Charlottesville, VA, USA

    Craig A. Peters

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  1. Robert L. Chevalier
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  2. Craig A. Peters
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Editors and Affiliations

  1. Medical College of Wisconsin, Wisconsin, USA

    Ellis Avner (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology) (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology)

  2. Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    William Harmon (Professor of Pediatrics, Director, Pediatric Nephrology) (Professor of Pediatrics, Director, Pediatric Nephrology)

  3. Service de Néphrologie Pédiatrique Centre de référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Hôpital Necker‐Enfants Malades, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    Patrick Niaudet

  4. Department of Pediatrics Wakayama Medical University, Wakayama Medical University Hospital, 641–8510811–1, Kimiidera, Wakayama City, Japan

    Norishige Yoshikawa (Professor and Chair Pediatrician‐in‐Chief) (Professor and Chair Pediatrician‐in‐Chief)

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Chevalier, R.L., Peters, C.A. (2009). Obstructive Uropathy. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76341-3_56

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