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Immune-mediated Glomerular Injury

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Pediatric Nephrology

Abstract

Glomerular injury is the central basis of renal insufficiency. Accumulated immunohistopathologic evidence from human kidney diseases and experimental glomerular disease models indicates that immunologic mechanisms are often pivotally involved in glomerular injury. Founded on the classical evidence, recent advances in basic immunology, the molecular and cellular biology of intrinsic glomerular cells, and genetic engineering in mice have provided significant clues to understanding the immune mechanisms that target the glomerulus.

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Acknowledgment

Author’s research and academic efforts are supported by Grants-in-Aid for Scientific Research (C) 19,590,932 and Scientific Research (S) 16,109,005 from the Japan Society for the Promotion of Science. Author thanks Drs Masaomi Nangaku and Takashi Wada for critical reading of the corresponding parts of the text. Most of the references sited here have been published after 2003. Given a limited capacity for citation, the reference includes many recent review articles, despite numerous important original works published before 2002. The author suggests the readers to reference Chapter 29 of fifth edition and Chapter 40 of the fourth edition which reference earlier published works.

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Authors and Affiliations

  1. Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    Michio Nagata

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  1. Michio Nagata
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Editors and Affiliations

  1. Medical College of Wisconsin, Wisconsin, USA

    Ellis Avner (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology) (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology)

  2. Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    William Harmon (Professor of Pediatrics, Director, Pediatric Nephrology) (Professor of Pediatrics, Director, Pediatric Nephrology)

  3. Service de Néphrologie Pédiatrique Centre de référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Hôpital Necker‐Enfants Malades, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    Patrick Niaudet

  4. Department of Pediatrics Wakayama Medical University, Wakayama Medical University Hospital, 641–8510811–1, Kimiidera, Wakayama City, Japan

    Norishige Yoshikawa (Professor and Chair Pediatrician‐in‐Chief) (Professor and Chair Pediatrician‐in‐Chief)

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© 2009 Springer-Verlag Berlin Heidelberg

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Nagata, M. (2009). Immune-mediated Glomerular Injury. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76341-3_29

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  • DOI: https://doi.org/10.1007/978-3-540-76341-3_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-76327-7

  • Online ISBN: 978-3-540-76341-3

  • eBook Packages: MedicineReference Module Medicine

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