Abstract
A novel method is presented for creating a probability map from histologically defined cytoarchitectonic data, customised for the anatomy of individual fMRI volunteers. Postmortem structural and cytoarchitectonic information from a published dataset is combined with high resolution structural MR images using deformable registration of a region of interest. In this paper, we have targeted the three sub-areas of the primary auditory cortex (located on Heschl’s gyrus); however, the method could be applied to any other cytoarchitectonic region. The resulting probability maps show a significantly higher overlap than previously generated maps using the same cytoarchitectonic data, and more accurately span the macroanatomical structure of the auditory cortex. This improvement indicates a high potential for spatially accurate fMRI analysis, allowing more reliable correlation between anatomical structure and function. We validate the approach using fMRI data from nine individuals, taken from a published dataset. We compare activation for stimuli evoking a pitch percept to activation for acoustically matched noise, and demonstrate that the primary auditory cortex (Te1.0) and the lateral region Te1.2 are sensitive to pitch, whereas Te1.1 is not.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Patterson, R., Uppenkamp, S., Johnsrude, I., Griffiths, T.: The processing of temporal pitch and melody information in auditory cortex. Neuron 36, 767–776 (2002)
Amunts, K., Zilles, K.: Advances in cytoarchitectonic mapping of the human cerebral cortex. Neuroimaging Clin N Am. 11, 151–169 (2001)
Zilles, K., Palomero-Gallagher, N., Grefkes, C., Scheperjans, F., Boy, C., Amunts, K., Schleicher, A.: Architectonics of the human cerebral cortex and transmitter receptor fingerprints: reconciling functional neuroanatomy and neurochemistry. Euro. Neuropsychopharmacology 12, 587–599 (2002)
Felleman, D., Van Essen, D.: Distributed hierarchical processing in the primate cerebral cortex. Cereb. Cortex 1, 1–47 (1991)
Passingham, R., Stephan, K., Kotter, R.: The anatomical basis of functional localization in the cortex. Nat. Rev. Neurosci. 3, 606–616 (2002)
Morosan, P., Rademacher, J., Schleicher, A., Amunts, K., Schormann, T., Zilles, K.: Human primary auditory cortex: Cytoarchitectonic subdivisions and mapping into a spatial reference system. NeuroImage 13, 684–701 (2001)
Schleicher, A., Amunts, K., Geyer, S., Morosan, P., Zilles, K.: Observer-independent method for microstructural parcellation of cerebral cortex: A quantitative approach to cytoarchitectonics. Neuroimage 9, 165–177 (1999)
Zilles, K., Schleicher, A., Palomero-Gallagher, N., Amunts, K.: Quantitative analysis of cyto- and receptorarchitecture of the human brain. In: Brain Mapping: The Methods 2nd edn., pp. 573–602 (2002)
Rademacher, J., Morosan, P., Schormann, T., Schleicher, A., Werner, C., Freund, H., Zilles, K.: Probabilistic mapping and volume measurement of human primary auditory cortex. Neuroimage 13, 669–683 (2001)
Penhune, V.B., Zatorre, R.J., MacDonald, J.D., Evans, A.C.: Interhemispheric anatomical differences in human primary auditory cortex: Probabilistic mapping and volume measurement from magnetic resonance scans. Cereb. Cortex 6, 661–672 (1996)
Crivello, F., Schormann, T., Tzourio-Mazoyer, N., Roland, P.E., Zilles, K., Mazoyer, B.M.: Comparison of spatial normalization procedures and their impact on functional maps. Human Brain Mapp. 16, 228–250 (2002)
Bendor, D., Wang, Q.: The neuronal representation of pitch in primate auditory cortex. Nature 436, 1161–1165 (2005)
Zatorre, R.J.: Finding the missing fundamental. Nature 436, 1093–1094 (2005)
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bailey, L. et al. (2007). Customised Cytoarchitectonic Probability Maps Using Deformable Registration: Primary Auditory Cortex. In: Ayache, N., Ourselin, S., Maeder, A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007. MICCAI 2007. Lecture Notes in Computer Science, vol 4792. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75759-7_92
Download citation
DOI: https://doi.org/10.1007/978-3-540-75759-7_92
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-75758-0
Online ISBN: 978-3-540-75759-7
eBook Packages: Computer ScienceComputer Science (R0)