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Pharmacology of Neurotransmitter Transport into Secretory Vesicles

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Pharmacology of Neurotransmitter Release

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 184))

Many neuropsychiatric disorders appear to involve a disturbance of chemical neurotransmission, and the mechanism of available therapeutic agents supports this impression. Postsynaptic receptors have received considerable attention as drug targets, but some of the most successful agents influence presynaptic processes, in particular neurotransmitter reuptake. The pharmacological potential of many other presynaptic elements, and in particular the machinery responsible for loading transmitter into vesicles, has received only limited attention. The similarity of vesicular transporters to bacterial drug resistance proteins and the increasing evidence for regulation of vesicle filling and recycling suggest that the pharmacological potential of vesicular transporters has been underestimated. In this review, we discuss the pharmacological effects of psychostimulants and therapeutic agents on transmitter release.

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Authors and Affiliations

  1. The Biotechnology Centre of Oslo, Centre for Molecular Biology and Neuroscience, University of Oslo, 1125, Blindern, Oslo, 0317, Norway

    Farrukh A. Chaudhry

  2. The Biotechnology Centre of Oslo, Centre for Molecular Biology and Neuroscience, University of Oslo, 0317, Oslo, Norway

    Jean-Luc Boulland

  3. The Biotechnology Centre of Oslo, Centre for Molecular Biology and Neuroscience, University of Oslo, N-0317, Oslo, Norway

    Monica Jenstad

  4. The Biotechnology Centre of Oslo, University of Oslo, 0317, Oslo, Norway

    May K. L. Bredahl

  5. Departments of Neurology and Physiology, University of California, San Francisco School of Medicine, 600 16th Street, GH-N272B San Francisco, California, 94143-2140, USA

    Robert H. Edwards

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  1. Howard Hughes Medical Institute and Center for Basic Neuroscience, UT Southwestern Medical Center, 6000 Harry Hines Blvd. NA4.118, Dallas, TX 75390, USA

    Thomas C. Südhof

  2. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 25, D-79104 Freiburg i.Br., Germany

    K. Starke  & Klaus Starke  & 

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Chaudhry, F.A., Boulland, JL., Jenstad, M., Bredahl, M.K.L., Edwards, R.H. (2008). Pharmacology of Neurotransmitter Transport into Secretory Vesicles. In: Südhof, T.C., Starke, K. (eds) Pharmacology of Neurotransmitter Release. Handbook of Experimental Pharmacology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74805-2_4

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