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Pathophysiology of Solid Tumors

  • Chapter
The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

It is generally accepted that tumor blood flow, microcirculation, oxygen and nutrient supply, tissue pH distribution, lactate levels, and the bioenergetic status— factors that are usually closely linked and that define the so-called pathophysiological microenvironment (“tumor pathophysiome”)—can markedly influence the therapeutic response of malignant tumors to conventional irradiation, chemotherapy, other non-surgical treatment modalities, malignant progression, and the cell proliferation activity within tumors. Currently available information on the parameters defining the pathophysiological micromilieu in human tumors is presented in this chapter. According to these data, significant variations in these relevant factors are likely to occur between different locations within a tumor and between tumors of the same grading and clinical staging. Therefore, evaluation of the pathophysiological microenvironment in individual tumors before therapy and a corresponding “fine-tuning” of treatment protocols for individual patients may result in an improved tumor response to treatment.

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099, Mainz, Germany

    Peter Vaupel MD, MA

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  1. Peter Vaupel MD, MA
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  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Michael Molls MD

  2. Institute of Physiology and Pathophysiology, University Medical Center, Duesbergweg 6, 55099, Mainz, Germany

    Peter Vaupel MD, MA

  3. Department of Internal Medicine – Oncology, Nordlandssykehuset HF Hospital, 8092, Bodø, Norway

    Carsten Nieder MD

  4. Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401 College Street, 980058, 23298-0058, Richmond, VA, USA

    Mitchell S. Anscher MD, FACR, FACRO

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Vaupel, P. (2009). Pathophysiology of Solid Tumors. In: Molls, M., Vaupel, P., Nieder, C., Anscher, M. (eds) The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74386-6_4

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