Immediately upon synthesis nascent transcripts associate with proteins to form large ribonucleoprotein (RNP) complexes, the protein content of which evolves as pre-mRNA is processed into mRNA and nuclear mRNA is exported to the cytoplasm (for recent reviews, see Dreyfuss et al. 2002; Reed and Hurt 2002). After being released from the gene templates, which are distributed throughout the nucleoplasm, messenger ribonucleoprotein particles (mRNPs) must reach the nuclear pore complexes in order to be transported to the cytoplasm – but what drives this intranuclear movement remains unknown.
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Braga, J., Rino, J., Carmo-Fonseca, M. (2008). Photobleaching Microscopy Reveals the Dynamics of mRNA-Binding Proteins Inside Live Cell Nuclei. In: Jeanteur, P. (eds) RNA Trafficking and Nuclear Structure Dynamics. Progress in Molecular and Subcellular Biology, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74266-1_6
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