Abstract
The paper presents application of time-gated, intensified CCD camera for imaging of local changes of absorption in the non-homogenous liquid phantom. The surface of the phantom was illuminated sequentially at 25 points (forming 5×5 array) by laser beam at wavelength of 780 nm generated by picosecond, near-infrared diode laser. The spatial distribution of diffusely reflected photons was measured in reflectance geometry at null source-detector separation. For each position of the laser beam the reflectance was measured for two different time windows, distinctly delayed in respect to the laser pulse. The observation of late photons, which penetrated deeply in the optically turbid medium allowed to image the absorbing inclusion (10 mm diameter black ball) located at depth of 15 mm. For each of two time windows the single images for all scanned points were summed. Obtained final images allowed to localize the non-homogeneity in the phantom. The study shows, that the presented method based on imaging at null source-detector separation distance for late time windows may be applied in the evaluation of the tissue absorption measurements, especially in the brain oxygenation imaging.
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References
Litscher, G. and G. Schwarz (1997) Transcranial cerebral oximetry. Pabst Sci. Pub. Lengerich.
Siegel, A.M., J.J.A. Marota, and D.A. Boas (1999) Design and evaluation of a continuous-wave diffuse optical tomography system. Optics Express 4(8): 287–298.
Boas, D.A., et al. (2001) The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics. Neuroimage 13(1): 76–90.
Franceschini, M.A., et al. (2003) Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging. Psychophysiology 40(4): 548–60.
Yamashita, Y., A. Maki, and H. Koizumi (1999) Measurement system for noninvasive dynamic optical topography. Journal Of Biomedical Optics 4(4): 414–417.
Kohl-Bareis, M., et al. (2002) Near-Infrared Spectroscopic Topographic Imaging of Cortical Activation. Lecture Notes of ICB Seminar on Laser Doppler Flowmetry and Near Infrared Spectroscopy in Medical Diagnosis, Warsaw.
Chance, B., et al. (1998) A novel method for fast imaging of brain function, non- invasively, with light. Optics Express 2(10): 411–423.
Danen, R.M., et al. (1998) Regional Imager for Low-Resolution Functional Imaging of the Brain with Diffusing Near-Infrared Light. Photochemistry and Photobiology 67(1): 33–40.
Eda, H., et al. (1999) Multichannel time-resolved optical tomographic imaging system. Review Of Scientific Instruments 70(9): 3595–3602.
Miyai, I., et al. (2001) Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 14(5): 1186–92.
Selb, J. (2005) et al., Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. J Biomed Opt 10(1): 11013.
Kacprzak, M., A. Liebert, and R. Maniewski (2005) A time-resolved NIR topography system for two hemispheres of the brain, in European Conferences on Biomedical Optics. Munich, Germany.
Wabnitz, H., et al. (2006) Depth-selective analysis of responses to functional stimulation recorded with a time-domain NIR brain imager, in Biomedical Optics 2006 Technical Digest (Optical Society of America, Washington, DC). p. ME34.
Contini, D., et al. (2006) Design and characterization of a two-wavelength multichannel time-resolved system for optical topography. Biomedical Optics Technical Digest (Optical Society of America, Washington, DC).
Selb, J., et. al. (2006) Time-gated optical system for depth-resolved functional brain imaging Journal of Biomedical Optics 11(4), 044008 (July/August)
Selb, J., et. al. (2005) Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system:analytical model and experimental validation, Journal of Biomedical Optics 10(1), 011013 (January/February)
D'Andrea, C., et al. (2003) Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera. Journal Of Physics D-Applied Physics 36(14): 1675–1681.
Laidevant, A., et al. (2006) Time-Resolved Imaging of a Fluorescent Inclusion in a Turbid Medium Using a Gated CCD Camera. in Biomedical Optics 2006 Technical Digest (Optical Society of America, Washington, DC). Fort Lauderdale, Florida, USA.
Sase, I., et. al. (2006) Noncontact backscatter-mode near-infrared time-resolved imaging system: preliminary study for functional brain mapping, Journal of Biomedical Optics 11,(5), 054006 (September/October)
Torricelli, A., et. al. (2005) Time-Resolved Reflectance at Null Source-Detector Separation:Improving Contrast and Resolution in Diffuse Optical Imaging, PRL 95, 078101
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Sawosz, P., Kacprzak, M., Liebert, A., Maniewski, R. (2007). Application of time-gated, intensified CCD camera for imaging of absorption changes in non-homogenous medium.. In: Jarm, T., Kramar, P., Zupanic, A. (eds) 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007. IFMBE Proceedings, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73044-6_104
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DOI: https://doi.org/10.1007/978-3-540-73044-6_104
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