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TLR9-Mediated Recognition of DNA

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Toll-Like Receptors (TLRs) and Innate Immunity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 183))

The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role in this process. TLRmediated signaling activates immune cells and leads to an innate immune response with subsequent initiation of an adaptive immune response. Toll-like receptor 9 (TLR9) recognizes deoxyribonucleic acid (DNA) leading to cellular activation and cytokine production influencing the immune response against viruses and bacteria. The stimulation of TLR9 will be exploited for adjuvant therapy and treatment of cancer or allergy. In this review we will discuss TLR9 ligands, TLR9 expression, signaling, and the therapeutic potential of TLR9 ligands in treatment of infectious or allergic diseases and cancer.

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Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstrasse 30, 81675, München

    Thomas Müller

  2. 4SC AG, Am Klopferspitz 19a, 82152, Martinsried, Germany

    Svetlana Hamm

  3. Institut für Immunology, Philipps-Universität Marburg, BMFZ, Hans-Meerweinstr. 2, 35043, Marburg, Germany

    Stefan Bauer

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  1. Thomas Müller
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  2. Svetlana Hamm
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  3. Stefan Bauer
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Editors and Affiliations

  1. Institut für Immunologie BMFZ, Philipps-Universität Marburg, Hans-Meerwein-Str. 2, D-35043, Marburg, Germany

    Stefan Bauer

  2. Abteilung für Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany

    Gunther Hartmann

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Müller, T., Hamm, S., Bauer, S. (2008). TLR9-Mediated Recognition of DNA. In: Bauer, S., Hartmann, G. (eds) Toll-Like Receptors (TLRs) and Innate Immunity. Handbook of Experimental Pharmacology, vol 183. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72167-3_3

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