Comparison of Two Methods to Develop Breast Models for Simulation of Breast Tomosynthesis and CT

Abstract

Dedicated x-ray computed tomography (CT) of the breast using a cone-beam flat-panel detector system is a modality under investigation by a number of research teams. Several teams, including ours, have fabricated prototype, bench-top flat-panel CT breast imaging (CTBI) systems. We also use computer simulation software to optimize system parameters. We are developing a methodology to use high resolution, low noise CT reconstructions of fresh mastectomy specimens in order to generate an ensemble of 3D digital breast phantoms that realistically model 3D compressed and uncompressed breast anatomy. The resulting breast models can then be used to simulate realistic projection data for both Breast Tomosynthesis (BT) and Breast CT (BCT) systems thereby providing a powerful evaluation and optimization mechanism for research and development of novel breast imaging systems as well as the optimization of imaging techniques for such systems. Having the capability of using breast object models and simulation software is clinically significant because prior to a clinical trial of any prototype breast imaging system many parameter tradeoffs can be investigated in a simulation environment. This capability is worthwhile not only for the obvious benefit of improving patient safety during initial clinical trials but also because simulation prior to prototype implementation should result in reduced cost and increased speed of development. The main goal of this study is to compare results obtained using two different methods to develop breast object models in order to select the better technique for developing the entire ensemble.