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Magnetic Resonance Imaging Studies of Cigarette Smoking

  • Chapter
Nicotine Psychopharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 192))

Abstract

This chapter reviews studies that have applied magnetic resonance imaging (MRI) toward a better understanding of the neurobiological correlates and consequences of cigarette smoking and nicotine dependence. The findings demonstrate that smokers differ from nonsmokers in regional brain structure and neurochemistry, as well as in activation in response to smoking-related stimuli and during the execution of cognitive tasks. We also review functional neuroimaging studies on the effects of nicotine administration on brain activity, both at rest and during the execution of cognitive tasks, independent of issues related to nicotine withdrawal and craving. Although chronic cigarette smoking is associated with poor cognitive performance, acute nicotine administration appears to enhance cognitive performance and increase neural efficiency in smokers.

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Authors and Affiliations

  1. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA

    Allen Azizian, John Monterosso & Joseph O'Neill

  2. Department of Psychiatry and Biobehavioral Sciences, Department of Molecular and Medical Pharmacology, and Brain Research Institute, University of California, Los Angeles, CA, USA

    Edythe D. London

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  1. Allen Azizian
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  2. John Monterosso
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  3. Joseph O'Neill
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  4. Edythe D. London
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Editors and Affiliations

  1. Pinney Associates, 3 Bethesda Metro Center, Bethesda, MD, 20814-3472, USA

    Jack E. Henningfield

  2. UCLA Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA, 90024-1759, USA

    Edythe D. London

  3. Center for Brain Research, Bornova, Ege University, Izmir, 35100, Turkey

    Sakire Pogun

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© 2009 Springer-Verlag Berlin Heidelberg

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Azizian, A., Monterosso, J., O'Neill, J., London, E.D. (2009). Magnetic Resonance Imaging Studies of Cigarette Smoking. In: Henningfield, J.E., London, E.D., Pogun, S. (eds) Nicotine Psychopharmacology. Handbook of Experimental Pharmacology, vol 192. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69248-5_5

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