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Molecular Biology of the Receptors for Somatostatin and Cortistatin

  • Chapter
Regulatory Peptides and Cognate Receptors

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 26))

Abstract

The neuropeptide somatostatin (SST) has been known for more than 25 years, and investigations into its function have yielded a large variety of physiological effects that can be ascribed to the peptide. These effects go far beyond the role as an inhibitor of the release of pituitary growth hormone which was observed initially. Consistently, somatostatin (and its more recently identified relative, cortistatin) exerts its functions via a whole family of different receptor subtypes. Since the molecular identification of these subtypes in the early 1990’s the assignment of specific functions to individual subtypes has been a major goal in somatostatin research. This review summarizes the recent advances that have been made with respect to the signal transduction by somatostatin receptors as well as the regulation of the receptors. In addition I will give an outlook on studies using mice deficient for individual receptor subtypes, which — in combination with newly deveolped subtype specific ligands — will hopefully provide a clearer picture of somatostatin receptor function in the near future.

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  1. Institut für Zellbiochemie und klinische Neurobiologie, Universitätskrankenhaus Eppendorf, Universität Hamburg, Martinistrasse 52, 20246, Hamburg, Germany

    Hans-Jürgen Kreienkamp

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  1. Hans-Jürgen Kreienkamp
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  1. Institut für Zellbiochemie und Klinische Neurobiologie, Universität Hamburg, Martinistr. 52, D-20246, Hamburg, Germany

    Dietmar Richter

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© 1999 Springer-Verlag Berlin Heidelberg

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Kreienkamp, HJ. (1999). Molecular Biology of the Receptors for Somatostatin and Cortistatin. In: Richter, D. (eds) Regulatory Peptides and Cognate Receptors. Results and Problems in Cell Differentiation, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49421-8_10

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  • DOI: https://doi.org/10.1007/978-3-540-49421-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12908-1

  • Online ISBN: 978-3-540-49421-8

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