Abstract
One of the hopes of the large-scale genetic screens in zebrafish was that they would be informative regarding the process of patterning organ systems. That single gene mutations could reveal a logic to developmental patterning was evident from previous genetic screens in Drosophila, and these genetic findings have been successfully extrapolated to vertebrates by dint of evolutionary gene conservation. However, the Drosophila screens revealed little about organogenesis. How are the size and global form of organs controlled? What controls the onset of physiological function, especially when integrated among organs? At which points do development of form and function intersect? Are the parts of a complex organ generated as individual units that can be ablated by mutations in single genes? Alternatively, are pathways so interwoven and entangled that all mutations lead to an uninterpretable jumble of amorphous tissue?
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© 2002 Springer-Verlag Berlin Heidelberg
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Yelon, D., Weinstein, B.M., Fishman, M.C. (2002). Cardiovascular System. In: Solnica-Krezel, L. (eds) Pattern Formation in Zebrafish. Results and Problems in Cell Differentiation, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46041-1_15
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DOI: https://doi.org/10.1007/978-3-540-46041-1_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-07811-8
Online ISBN: 978-3-540-46041-1
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