Abstract
From our better understanding of the natural history of prostate cancer, it is not unreasonable to believe that the disease is preventable. Prostate cancer has become a major healthcare problem worldwide, as life expectancy increases. Moreover, the cancer is slow growing, with a period of about 20–25 years from initiation to the stage when the clinically detectable phenotype can be identified. This review provides a simple overview of the endocrinology of prostate cancer and discusses some of the pharmaceutical agents that have been or are being tested to restrain, possibly arrest, the progression of this slowly growing cancer. Also discussed are many of the dietary factors that may influence the molecular or endocrine events implicated in its development. Dietary factors are considered responsible for the geographical differences in prostate cancer incidence and mortality. Since about 50% of all men worldwide, from both East and West, show evidence of microscopic cancer by 50 years of age, growth restraint would appear to be the pragmatic option to the possibility of preventing initiation.
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References
Huggins C (1963) Introduction. In: Vollmer EP, Kauffmann G (eds) Biology of the prostate and related tissues, monograph 12. National Cancer Institute, U.S. Department of Health Education and Welfare, pp xi–xii
Parkin DM, Whelan SI, Ferlay J, Raymond L, Young J (eds) (1997) Cancer incidence in five continents, vol VII. Scientific Publications
Adlercreutz H (1990) Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand J Clin Lab Invest Suppl 50:3–23
Griffiths K, Adlercreutz H, Boyle P, Denis L, Nicholson RI, Morton MS (1996) Nutrition and cancer. Isis Medical Media, Oxford
Griffiths K, Cockett ATK, Coffey D, Di Sant’Agnese A, Krieg M, Lee C, McKeehan W, Neal DE, Partin A, Schalken J (1997) Regulation of prostatic growth. In: Denis L, Griffiths K, Khoury S, Cockett ATK, McConnell J, Chatelain C, Murphy G, Yoshida O (eds) The 4th International Consultation on BPH. SCI, Paris, pp 85–128
Lee C, Cockett A, Cussenot O, Griffiths K, Isaacs W, Scalken J (2001) Regulation of prostate growth. In: Chatelain C, Denis L, Foo KT, Khoury S, Mc-Connell J (eds) Benign prostatic hyperplasia, the 5th International Consultation on BPH. Health Publications, Paris, pp 81–106
Weihua Z, Makela S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA (2001) A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc Natl Acad Sci U S A 98:6330–6335
Bartsch G, Klocker H, Ackermann R, Di Sant’Agnese PA, Cussenot O, Lee C, Narayan P, Nelson J, Salgaller ML, Schulman CC, Steiner MS (2000) Translational research areas and new treatment modalities. In: Murphy G, et al (eds) Second International Consultation on Prostate Cancer. Health Publications, Paris, pp 59–136
Griffiths K, Denis LJ, Turkes A (2002) Oestrogens, phyto-oestrogens and the pathogenesis of prostatic disease. Martin Dunitz, London
World Cancer Research Fund (1997) Food, nutrition and the prevention of cancer: a global perspective. Banta Book Group, Manasha
De Koning HJ, Auvinen A, Berenguer Sanchez A, et al (2002) Large scale randomised prostate cancer screening trials: program performances in the European Randomized Screening for Prostate Cancer and the Prostate, lung, Colorectal and Ovary Cancer Trial. Int J Cancer 97:237–244
Griffiths K, The Internatonal Prostate Health Council Study Group (2000) Estrogens and prostatic disease (review). Prostate 45:87–100
Rotkin ID (1976) Epidemiology of benign prostatic hypertrophy: Review and speculations. In: J.T. Grayhack, J.D. Wilson & M.J. Saherbenske (eds) Benign prostatic hyperplasia. DHEW Publications, pp 105–117
Rotkin ID (1980) Epidemiologic clues to increased risk of prostae cancer. In: Spring-Mills E, Hafez ESE (eds) Male accessory sex glands: biology and pathology. Elsevier/North-Holland Medical Press, Amsterdam, pp 289–311
Chang WY, Birch L, Woodham C, Gold LI, Prins GS (1999) Neonatal estrogen exposure alters the transforming growth factor-beta signaling system in the developing rat prostate and blocks the transient p21 (cip1/waf1) expression associated with epithelial differentiation. Endocrinology 140:2801–2813
Wang YZ, Hayward SW, Cao M, Young P, Cardiff R, Cunha GR (2001) Role of estrogen signalling in prostatic hormonal carcinogenesis. J Urol (Suppl) 165:132–133
Risbridger G, Wang H, Frydenberg M, Cunha GR (2001) The metaplastic effects of estrogen on prostate epithelium proliferation of cells with basal cell phenotype. Endocrinology 142:2443–2450
Cunha GR, Hayward SW, Wang YZ, Ricke WA (2003) Role of the stromal microenvironment in carcinogenesis of the prostate. Int J Cancer 107:1–10
Berry SJ, Coffey DS, Walsh PC, Ewing LL (1984) The development of human benign prostatic hyperplasia with age. J Urol 132:474–479
McNeal JE (1984) Anatomy of the prostate and morphogenesis of BPH. In: Kimball FA, Buhl AE, Carter DB (eds) New approaches to the study of benign prostatic hyperplasia. Alan R Liss, New York, pp 27–53
Sakr WA (1999) Prostatic intraepithelial neoplasia: a marker for high-risk groups and a potential target for chemoprevention. Eur Urol 35:474–478
Sakr WA, Partin AW (2001) Histological markers of risk and the role of high-grade prostatic intraepithelial neoplasia (Review). Urology 57(Suppl):115–120
Bostwick DG, Pacelli A, Lopez-Beltran A (1996) Molecular biology of prostatic intraepithelial hyperplasia. Prostate 29:117–134
De Marzo AM, Nelson WG, Isaacs WB, Epstein JI (2003) Pathological and molecular aspects of prostate cancer. Lancet 361:955–964
De Marzo AM, Marchi VL, Epstein JI, Nelson WG (1999) Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol 155:1985–1992
Naslund M, Coffey DS (1986) The differential effects of neonatal androgen, estrogen and progesterone on adult rat prostate growth. J Urol 136:1136–1140
Coffey DS (2001) Similarities of prostate and breast cancer: evolution, diet and estrogens. Urology 57Suppl 57:31–38
Putzi MJ, De Marzo AM (2000) Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia. Urology 56:828–832
Nelson WG, De Marzo AM, Deweese TL, Lin X, Brooks JD, Putzi MJ, Nelson CP, Groopman JD, Kensler TW (2001) Preneoplastic prostate lesions: an opportunity for prostate cancer prevention. Ann N Y Acad Sci 952:135–144
Prezioso D, et al (2005) Oestrogens and diseases of the prostate gland (In press)
Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM (1991) Brit. Cancer 63:963–966
Watanaba S (1993) Large-scale, populationbased prospective studies in Japan. Eur J Cancer 29A:2305–2314
Hsing AW, Tsao I, Devesa SS (2000) International trends and patterns of prostate cancer incidence and mortality. Int J Cancer 85:60–67
Thompson IM, Albanes D, Griffiths K et al (2003) Chemoprevention on prostate cancer. In: Denis L, Khoury S, Chatelain C, et al (eds) Third International Consultation on Prostate Cancer: New treatment modalities. Health Publications
Gann PH, Akaza H, Habib F, Kirby R, Mendoza AV, Thompson IM, Van Poppel H (2006) Prostate cancer prevention. In: Proceedings of the Sixth International Consultation on Prostate Cancer; New Development in Prostate Cancer, Paris, 24–27 June 2005. pp 247–274
Parnes HL, House MG, Kagan J, Kausal DJ, Lieberman R (2004) Prostate cancer chemoprevention agent development: the national cancer institute, division of cancer prevention portfolio. J Urol 171:S68–S75
Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson JA, Kushner PJ, Scanlan TN (1997) Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP-1 sites. Science 277:1508–1510
Bektic J, Berger AP, Pfeil K, Dobler G, Bartsch G, Klocker H (2004) Androgen receptor regulation by physiological concentratins of the isoflavnoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor β. Eur Urol 45:245–251
Matthews J, Gustafsson JA (2003) Estrogen signaling: a subtle balance between ER alpha and ER beta (Review). Mol Interv 3:281–292
Price KR, Fenwick GR (1985) Naturally occurring oestrogens in food-a review. Food Addit Contam 2:73–106
Hellendoorn EW (1976) Beneficial physiologic action of beans. J Am Diet Assoc 69:248–253
Adlercreutz H, Fotsis T, Lampe J, Wahala K, Makela T, Brunow G, Hase T (1993) Quantative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest 53:(Suppl) 5–18
Morton MS, Chan PS, Cheng C, Blacklock N, Matos-Ferreira A, Abranches-Monteiro L, Lloyd S, Griffiths K (1997) Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong and the United Kingdom. Prostate 32:122–128
Pumford SL, Morton MS, Turkes A, Griffiths K (2002) Determination of the isoflavonoids genistein and daidzein in biological samples by gas chromatography-mass spectrometry. Ann Clin Biochem 39:281–292
Kuhnau J (1976) The flavonoids. A class of semiessential food components: their role in human nutrition. World Rev Nutr Diet 24:117–191
Waladkhani A, Clemens MR (1998) Effect of dietary phytochemicals on cancer development (Review). Int J Mol Med 1:747–753
Nutrient Data Laboratory (2003) USDA database for the flavonoid content of selected foods. U.S. Department of Agriculture, pp 1–77
Rao CV, Rivensen A, Simi B, Reddy BS (1995) Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring phenolic compound. Cancer Res 55:259–266
Miksicek RJ (1995) Estrogenic flavonoids: structuralrequirements for biological activity. Proc Soc Exp Biol Med 208:440–450
Galati G, O’Brien JP (2004) Potential toxicity off flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37:287–303
Wolf CR (2001) Chemoprevention: increased potential to bear fruit. Proc Natl Acad Sci U S A 98:2941–2943
Shamberger RJ, Frost DV (1969) Possible protective effect of selenium against human cancer. Can Med Assoc J 100:682
Comstock GW, Bush TL, Helzlsouer K (1992) Serum retinol, beta-carotene, vitamin E and selenium as related to subsequent cancer specific sites. Am J Epidemiol 135:115–121
Combs GF (1997) Antioxidants and disease prevention. In: Garewal HS (ed) Selenium and cancer prevention. pp 97–112
Medina D, Morrison DG (1988) Current ideas on selenium as a chemopreventive agent. Pathol Immunopathol Res 7:187–199
Menter DG, Sabichi AL, Lippman SM (2000) Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev 9:1171–1182
Yoshizawa K, Willett WC, Morris SJ, Stampfer MJ, Spiegelman D, Rimm EB, Giovannucci E (1998) Study of prediagnostic selenium levels in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst 90:1219–1224
Clark LC, Dalkin B, Krongrad A, Combs GF, Turnbull BW, Slate EH, Witherington R, Herlong JH, Janosko E, Carpenter D, Borosso C, Falk S, Rounder J (1998) Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br J Urol 81:730–734
Rayman MP (1997) Dietary selenium: time to act. Br Med J 314:387–388
Howe GR (1990) Dietary fat and risk of breast cancer: combined analysis of 12 case-control studies. J Natl Cancer Inst 82:561–569
Garland M, Willett WC, Manson JE, Hunter DJ (1993) Antioxidant micronutrients and breast cancer. J Am Coll Nutr 12:400–411
Hunter DJ, Manson J, Colditz GA, Stampfer MJ, Rosner B, Hennekens CH, Speizer FE, Willett WC (1993) A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med 329:234–240
Boyle P, Maisonneuve P (1996) Diet, In: J. Waxman (ed) Molecular endocrinology of cancer. Cambridge University Press, pp 216–268
Boyle P, Maisonneuve P, Evstififeeva T, Alexander FE (1995) What is the significance of trends in prostate cancer? In: Murphy GP, Khoury S, Chatelain C, Denis L (eds) Fourth International Symposium on Recent Advances in Urological Cancer, Diagnosis and Treatment. SCI, Paris, pp 51–65
Albanes D, Heinonen OP, Huttunen JK, Taylor PR, Virtamo J, Edwards BK, Haapakoski J, Rautalahti M, Hartman AM, Palmgren J (1995) Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-carotene Cancer Prevention Study. Am J Clin Nutr 62(Suppl):1427S–1430S
Agarwal S, Roa AV (2000) Tomato, lycopene and its role in human health and chronic diseases. CMAJ 163:739–744
Sies H, Stahl W (1995) Vitamins E and C, β-carotene and other carotenoids as antioxidants. Am J Clin Nutr 62(Suppl 6):1315S–1321S
Kohimeier L, Kark JD, Gomez-Gracia E, Martin BC, Steek SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ (1997) Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol 146:618–626
Kotake-Nara E, Kushiro M, Zhang H, Sugawara T, Mayashita K, Nagao A (2001) Carotenoids affect the proliferation of human prostate cancer cells. J Nutr 131:3303–3306
Karas M, Amir H, Fishman D, Danilenko M, Segal S, Nahum A, Koifmann A, Giat Y, Levy J, Sharoni Y (2000) Lycopene interferes with cell cycle progression and insulin-like growth factor I signalling in mammary cancer cells. Nutr Cancer 36:101–111
Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW, Clinton SK (2003) Prostate carcinogenesis in N-methyl_N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst 95:1578–1586
Giovannucci E, Rimm ED, Liu Y, Stampfer MJ, Willett WC (2002) A prospective study of tomato products, lycopene and prostate cancer. J Natl Cancer Inst 94:391–398
Moon RC, Mehta RG (1990) Chemoprevention of mammary cancer by retinoids. Basic Life Sci 52:213–224
Olsen JA (1989) Provitamin A function of carotenoids: the conversion of ?-carotene into vitamin A. J Nutr 119:105–108
Parker RS (1989) Carotenoids in human blood and tissues. J Nutr 119:101–104
Hayes RB, Bogdanovicz JF, Schroeder FH, De Bruijn A, Raatgever JW, van der Maas PJ, Oishi K, Yoshida O (1988) Serum retinol and prostatic cancer. Cancer 62:2021–2026
Lasnitski I (1955) The influence of A-hypervitaminosis on the effect of 20-methylcholanthrene on mouse prostate glands in vitro. Br J Cancer 9:434–441
Lasnitski I (1976) Reversal of methylcholanthrene-induced changes in mouse prostates in vitro by retinoic acid and its analogues. Br J Cancer 34:239–248
Petkovich M, Brand NJ, Krust A, Chambon P (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444–450
Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM (1990) nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345:224–229
Zhang XK, Lehmann J, Hoffmann B, Dawson M, Cameron J, Graupner G, Hermann T, Pfahl M (1992) Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature 358:587–591
Blumberg B, Mangelsdorf DJ, Dyck JA, Bittner DA, Evans RM, De Robertis EM (1992) Multiple retinoid-responsive receptors in a single cell: families of retinoid “X” receptors and retinoic acid receptors in the Xenopus egg. Proc Natl Acad Sci U S A 89:2321–2325
Freedman LP, Arce V, Fernandez RP (1994) DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor. Mol Endocrinol 8:265–273
Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992) Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signaling. Nature 355:446–449
Graupner G, Zhang XK, Tzukerman M, Wills K, Hermann T, Pfahl M (1991) Thyroid hormone receptors repress estrogen receptor activation of a TRE. Mol Endocrinol 5:365–372
Ptahl M (1993) Nuclear receptor/AP-1 interaction. Endocr Rev 14:651–658
Roberts AB, Sporn MB (1984) Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS (eds) The retinoids. The Academic Press, Orlando, pp 209–286
de The H, Marchio A, Tiollais P, Dejean A (1989) Differential expression and ligand regulation of the retinoic acid receptor α and β genes. EMBO J 8:429–433
Dolle P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P (1989) Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature 342:702–705
Jones HE, Eaton CL, Barrow D, Dutkowski C, Griffiths K (1997) Response of cell growth and retinoic acid receptor expression to retinoic acid in neoplastic prostate cell lines. Prostate 30:174–182
Roman SD, Ormandy CJ, Manning DL, Blamey RW, Nicholson RI, Sutherland RL, Clarke CL (1993) Estradiol induction of retinoic acid receptors in human breast. Cancer Res 53:5940–5945
Schule R, Rangarajan P, Yang N, Kliewer S, Ransone LJ, Bolado J, Verma IM, Evans RM (1991) Retinoic acid is a negative regulator of AP-1 responsive genes. Proc Natl Acad Sci U S A 88:6092–6096
Yang-Yen HF, Zhang XK, Graupner G, Tzukerman M, Sakamoto B, Karin M, Pfahl M (1991) Antagonism between retinoic acid receptors and AP-1: implication for tumor promotion and inflammation. New Biol 3:1206–1219
Schwartz GG, Hulka BS (1990) Is vitamin D deficiency a risk factor for prostate cancer? Anticancer Res 10:1307–1311
Corder EH, Guess HA, Hulka B, Friedman GD, Sadler M, Vollmer RT, Lobaugh B, Drezner MK, Vogelman JH, Orentreich N (1993) Vitamin D and prostate cancer: a prediagnostic study with stored data. Cancer Epidemiol Biomarkers Prev 2:467–472
Pike JW (1991) Vitamin D3 receptors: structure and function in transcription. Annu Rev Nutr 11:189–216
Hosomi J, Hosoi J, Abe E, Suda T, Kuroki T (1983) Regulation of terminal differentiation of cultured mouse epidermal cells by 1α,25-dihydroxyvitamin D3. Endocrinology 113:1950–1957
Matsumoto K, Hashimoto K, Nishidi Y, Hashiro M, Yoshikawa K (1990) Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal human keratinocytes cultured in serum-free medium. Biochem Biophys Res Commun 166:916–923
Ahonen MH, Tenkanen L, Teppo L, et al (2000) Prostate cancer risk and prediagnostic serun 25-hydroxyvitamin D levels in Finland. Cancer Causes Control 11:847–852
Wynder EL, Mabuchi K, Whitmore WF (1971) Epidemiology of cancer of the prostate. Cancer 28:344–360
Huggins C, Stevens RE, Hodges CV (1941) Studies on prostatic cancer II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 43:209–223
Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE (1974) Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science 186:1213–1215
Imperato-McGinley J, Peterson RE, Gautier T, Sturla F (1979) Androgens and the evolution of male gender identity among male pseudohermaphrodites with 5-alpha reductase deficiency. N Engl J Med 300:1233–1237
Stoner E (1990) The clinical development of a 5alpha-reductase inhibitor, finasteride. J Steroid Biochem 37:375–384
McConnell JD, Wilson JD, George FW, Geller J, Pappas F, Stoner E (1992) Finasteride, an inhibitor of 5alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab 74:505–508
Unger JM, Thompson IM, LeBlanc M, Crowley JJ, Goodman PJ, Ford LG, Coltman CA (2005) Estimated impact of the prostate cancer prevention trial on population mortality. Cancer 103:1375–1380
Thompson IM, Goodman PJ, Tangem CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA Jr (2003) The influence of finasteride on the development of prostate cancer. N Engl J Med 349:215–224
Raghow S, Hooshdaran MZ, Katiyar S, et al (2002) Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model. Cancer Res 62:1370–1376
Risbridger G, Wang H, Young P, et al (2001) Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates the effects of estrogen on prostatic epithelium. Dev Biol 229:432–442
Steiner MS, Boger R, Barnette KG, Mitchell J, Bostwick D, Price D (2005) Evaluation of toremifene in reducing prostate cancer incidence in high risk men. 2005 Prostate Cancer Symposium. Am Soc Clin Oncol, abstr 7
Meikle AW, Smith JR, West DW (1985) Familial factors affecting prostatic cancer risk and plasma sex-steroid levels. Prostate 6:121–128
Gronberg H (2003) Prostate cancer epidemiology. Lancet 361:859–864
Eales RA, Durocher F, Edwards S, et al (1998) Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The CRC-British Prostate Group Familial Prostate Cancer Study. Am J Hum Genet 62:653–658
Coetzee GA, Ross RK (1994) Prostate cancer and the androgen receptor. J Natl Cancer Inst 86:872–873
Makridakis NM, Ross RK, Pike MC, Crocitto LE, Kolonel LN, Pearce CL, Hendersen BE, Reichardt JK (1999) Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles. Lancet 354:975–978
Culig Z, Klocker H, Bartsch G, Hobisch A (2002) Androgen receptors in prostate cancer. Endocr Relat Cancer 9:155–170
Ross RK (2001) The role of molecular genetics in chemoprevention studies of prostate cancer. In: Miller AB, et al (eds) Biomarkers in cancer prevention. IARC Scientific Publications, Lyon
Lopez-Otin C, Diamandis E (1998) Breast and prostate cancer: an analysis of common epidemiological, genetic and biochemical features. Endocr Rev 19:365–396
Imamov O, Lopatkin NA, Gustafsson JA (2004) Estrogen receptor beta in prostate cancer. N Engl J Med 351:2773–2774
Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15:617–631
Riboli E (2001) The european prospective investigation into cancer and nutrition (EPIC). J Nutr 131:170S–175S
Flegal KM, Carroll MD, Ogden CL, Johnson CL (2002) Prevalence and trends in obesity among US adults, 1999–2000. JAMA 288:1723–1727
Moyad MA (2002) Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning from breast or other cancers, and the big picture. Urology 59(Suppl 1):51–62
Skrabanek P (1994) Invited viewpoints. Eur J Cancer 30A:220–221
Taubes G (2001) The soft science of dietary fat. Science 291:2536–2545
Freedland SJ, Aronson WJ (2004) Examining the relationship between obesity and prostate cancer. Rev Urol 6:73–81
Engeland A, Tretli S, Bjorge T (2003) Height, body mass index and prostate cancer: a follow-up of 950,000 Norwegian men. Br J Cancer 89:1237–1242
Giovannucci E, Rimm EB, Liu Y, et al (2003) Body mass index and risk of prostate cancer in U. health professionals. J Natl Cancer Inst 95:1240–1244
Adlercreutz H, Bannwart C, Wahala K, Makela T, Brunow G, Hase T, Arosenema PJ, Kellis JT, Vickery LE (1993) Inhibition of human aromatase by mammalian lignan and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 44:147–153
Okasha M, McCarron P, McEwen J, Smith GD (2002) Body mass index in young adulthood and cancer mortality: a retrospective cohort study. J Epidemiol Community Health 56:780–784
Kaaks R (2001) Energy balance and cancer: the role of insulin and insulin-like growing factor-I. Proc Nutr Soc 60:91–106
Kaaks R, Lukanova A, Sommersberg B (2000) Plasma androgens, IGF-I and prostate cancer risk: a synthetic review. Prostate Cancer Prostatic Dis 3:157–172
Barnard RJ, Aronson WJ, Tymchk CN, Ngo TH (2002) Prostate cancer: another aspect of the insulin-resistance syndrome. Obes Rev 3:303–308
Yu H, Rohan T (2000) Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 92:1472–1489
Kaplan PJ, Mohan S, Cohen P, Foster BA, Greenberg NM (1999) The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Cancer Res 59:2203–2209
Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens H, Pollak M (1998) Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279:563–566
Turkes A, Peeling WB, Griffiths K (2000) Serum IGF-1 determination in relation to prostate cancer screening: possible differential diagnosis in relation to PSA assays. Prostate Cancer Prostatic Dis 3:173–175
Allen NE, Key TJ (2001) Plasma insulin-like growth factor-I, insulin-like growth factor binding proteins and prostate cancer risk: a prospective study. J Natl Cancer Inst 93:649–651
Apter D, Vihko R (1983) Early menarche, a risk factor for breast cancer, indicates early onset of ovulatory cycles. J Clin Endocrinol Metab 57:82–86
Lim SD, Sun C, Lambeth JD, Marshall F, Amin M, Chung L, Petros JA, Arnold RS (2005) Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate 62:200–207
Zha S, Gage WR, Sauvageot J, Saria EA, Putzi MJ, Ewing CM, Faith DA, Nelson WG, De Marzo AM, Isaacs WB (2001) Cyclooxygenase-2 is upregulated in proliferative inflammatory atrophy of the prostate, but not in prostate cancinoma. Cancer Res 61:8617–8623
Thun MJ, Henley SJ, Patrono C (2002) Nonsteroidal anti-inflammatory drugs as anti-cancer agents: mechanistic, parmacologic and clinical issues. J Natl Cancer Inst 94:252–257
Montano MM, Jaiswal AK, Katzenellenbogan BS (1998) Transcriptional regulation of the human quinone reductase gene by anti-estrogen liganded estrogen receptor-alpha and estrogen receptorbeta. J Biol Chem 273:25443–25449 i
Hedlund TE, Johannes WU, Miller GI (2003) Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro. Prostate 54:68–78
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD (2005) Dietary flavonols and flavanol-rich foods intake and the risk of breast cancer. Int J Cancer 114:628–633
Ratan HL, Steward WP, Gescher AJ, Mellon JK (2002) Resveratrol: a prostate cancer chemopreventive agent. Urol Oncol 7:223–227
Soleas GJ, Diamandis EP, Goldberg DM (1997) Wine as a biological fluid: history, production and role in disease prevention. J Clin Lab Anal 11:287–313
Shen G, Guo-Zhen L, Zhengxin W (2004) Modulation of androgen receptor-dependent transcription by resveratrol and genistein in prostate cancer cells. Prostate 59:214–225
Scaltriti M, Belloni L, Caporali A, Davalli P, Remondini D, Rizzi F, Astancolle S, Corti A, Bettuzzi S (2005) Molecular classification of green tea catechin-sensitive and-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling. Carcinogenesis 27:1047–1053
Mazur WM, Adlercreutz H (1998) Naturally occurring oestrogens in food. Pure Appl Chem 70:1759–1776
Adhami VM, Siddiqui IA, Ahmad N, Gupta S, Mukhtar H (2004) Oral consumption of green tea polyphenols inhibits insulin-like growth factor I-induced signalling in an autochthonous mouse model of prostate cancer. Cancer Res 64:8715–8722
Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from one-year proof-of-principle study. Cancer Res 66:1234–1240
Jian L, Xie LP, Lee AH, Binns CW (2004) Protective effect of green tea against prostate cancer: a case-control study in South Eastern China. Int J Cancer 108:130–135
Pezzato E, Sartor L, Dell’Aica I, Dittadi R, Gion M, Bellucco C, Lise M, Garbisa S (2004) Prostate carcinoma and green tea: PSA-triggered basement membrane degradation and MMP-2 activation are inhibited by (-)epigallocatechin-3-gallate. Int J Cancer 112:787–792
Ren F, Zhang S, Mitchell SH, Butler R, Young CYF (2000) Tea polyphenols down-regulate the expression of androgen receptor in LNCaP prostate cancer cells. Oncogene 19:1924–1932
Purohit V (2000) Can alcohol promote the aromatisation of androgens to estrogens? A review. Alcohol 22:123–127
Fahey JW, Zhang Y, Talalay P (1997) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect agains chemical carcinogens. Proc Natl Acad Sci U S A 94:10367–10372
Fereira CG, Epping M, Kruyt FA, Giaccone G (2002) Apoptosis: target of cancr therapy. Clin Cancer Res 8:2024–2034
Reed JC (1999) Dysregulation of apoptosis in cancer. J Clin Oncol 17:2941–2953
Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN (1991) Selective inhibition of isoprenylation of 21/26 kDa proteins by the anti-carcinogenic d-limonene and its metabolites. J Biol Chem 266:176–179
Magee T, Marshall C (1999) New insights into the interaction of Ras with plasma membrane. Cell 98:9–12
Miyamoto M, Matsushita Y, Kiyokawa A, Fukuda C, Iijima Y, Sugano M, Akiyama T (1998) Prenylflavonoids: a new class of non-steroidal phytoestrogen. Estrogenic effects of 8-isopentenylnaringenin on bone metabolism. Planta Med 64:516–519
Theriault A, Chao JT, Wang Q, Gapor A, Adeli K (1999) Tocotrienol: a review of its therapeutic potential. Clin Biochem 32:309–319
Bradlow L, Telang NT, Osborn MP (1996) Estrogen metabolites as bioreactive modulators of tumor initiation and promoters. Adv Exp Med Biol 367:285–296
Fotsis T, Zhang Y, Pepper MS, Adlercreutz H, Montesano R, Nawroth PP, Schweigerer L (1994) The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 368:237–239
Bonkhoff H, Fixemer T, Hunsicker I, Remberger K (1999) Estrogen receptor expression in prostatic cancer and premalignant prostatic lesions. Am J Pathol 155:641–647
Liotta LA, Steeg PS, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327–336
Brewster AM, Christo DK, Lai H, Helzlsouer K (2005) Breast carcinoma chemoprevention in the community setting: estimating risks and benefits. Cancer 103:1147–1153
Hirayama T (1979) Epidemiology of prostate cancer with special reference to the role of diet. Natl Cancer Inst Monogr Nov:149–155
Sporn MB (1996) The war on cancer. Lancet 347:1377–1381
Briel M, Nordmann AJ, Bucher HC (2005) Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and meta-analyses. Curr Opin Lipidol 16:601–605
Palmer ME, Haller C, McKinney PE, Klein-Schwartz W, Tschirgi A, Smolinske SC, Woolf A, Sprague BM, Ko R, Everson G, Nelson LS, Dodd-Butera T, Bartlett WD, Landzberg BR (2003) Adverse events associated with dietary supplements: an observational study. Lancet 361:101–106
Stephens NG, Parsons A, Scholfield PM, Kelly F, Cheeseman K, Mitchinson MJ (1996) Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge heart anti-oxidant study (CHAOS). Lancet 347:781–786
GISSI-Prevenzione Investigators (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione Trial. Lancet 354:447–455
Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142:140–146
Cook NR, Stampfer MJ, Ma J, Manson JE, Sacks FM, Buring JE, Hennekens CH (1999) Beta-carotene supplementation for patients with low baseline levels and decreased risks of prostate carcinoma and cancer overall. Cancer 86:1783–1792
Larkin M (1998) Controversy over diet to “prevent cancer”. Lancet 52:1789–1790
Sonn GA, Aronson W, Litwin MS (2005) Impact of diet on prostate cancer: a review. Prostate Cancer Prostatic Dis 8:304–310
Yan L, Spitznagel EL (2005) Meta-analysis of soy food and risk of prostatic cancer in men. Int J Cancer 117:667–669
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Griffiths, K., Prezioso, D., Turkes, A., Denis, L.J. (2007). The Prevention of Prostate Cancer. In: Ramon, J., Denis, L.J. (eds) Prostate Cancer. Recent Results in Cancer Research, vol 175. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-40901-4_4
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