Abstract
Solar ultraviolet B (UVB) irradiance and/or vitamin D have been found inversely correlated with incidence, mortality, and/or survival rates for breast, colorectal, ovarian, and prostate cancer and Hodgkin’s and non-Hodgkin’s lymphoma. Evidence is emerging that more than 17 different types of cancer are likely to be vitamin Dsensitive. A recent meta-analysis concluded that 1,000 IU of oral vitamin D per day is associated with a 50% reduction in colorectal cancer incidence. Using this value, as well as the findings in a multifactorial ecologic study of cancer mortality rates in the US, estimates for reductions in risk of vitamin D-sensitive cancer mortality rates were made for 1,000 IU/day. These estimates, along with annual average serum 25-hydroxyvitamin D levels, were used to estimate the reduction in cancer mortality rates in several Western European and North American countries that would result from intake of 1,000 IU/day of vitamin D. It was estimated that reductions could be 7% for males and 9% for females in the US and 14% for males and 20% for females in Western European countries below 59°. It is proposed that increased fortification of food and increased availability of supplements could help increase vitamin D intake and could augment small increases in production of vitamin D from solar UVB irradiance. Providing 1,000 IU of vitamin D per day for all adult Americans would cost about $1 billion; the expected benefits for cancer would be in the range of $16–25 billion in addition to other health benefits of vitamin D.
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References
Agar NS, Halliday GM, Barnetson RS et al (2004) The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc Natl Acad Sci U S A 101:4954–4959
Andersen R, Brot C, Ovesen L et al (2001) Towards a strategy for optimal vitamin D fortification (OPTIFORD). Nutr Metab Cardiovasc Dis 11:74–77
Bates CJ, Prentice A, Cole TJ et al (1999) Micronutrients: highlights and research challenges from the 1994-5 National Diet and Nutrition Survey of people aged 65 years and over. Br J Nutr 82:7–15
Bettica P, Bevilacqua M, Vago T et al (1999) High prevalence of hypovitaminosis D among free-living postmenopausal women referred to an osteoporosis outpatient clinic in northern Italy for initial screening. Osteoporos Int 9:226–229
Boonen S, Vanderschueren D, Cheng XG et al (1997) Age-related (type II) femoral neck osteoporosis in men: biochemical evidence for both hypovitaminosis D-and androgen deficiency-induced bone resorption J Bone Miner Res 12:2119–2126
Calvo MS, Whiting SJ, Barton CN et al (2004) Vitamin D fortification in the United States and Canada: current status and data needs. Am J Clin Nutr 80:1710S–1716S
Calvo MS, Whiting SJ, Barton CN et al (2005) Vitamin D intake: a global perspective of current status. J Nutr 135:310–316
Cross HS, Peterlik M, Reddy GS, Schuster I (1997) Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism. J Steroid Biochem Mol Biol 62:21–28
Daly RM, Brown M, Bass S et al (2006) Calcium-and vitamin D(3)-fortified milk reduces bone loss at clinically relevant skeletal sites in older men: a 2-year randomized controlled trial. J Bone Miner Res 21:397–405
Devesa SS, Grauman DJ, Blot WJ, Pennello G, Hoover RN, Fraumeni JF Jr (1999) Atlas of Cancer Mortality in the United States, 1950–1994. NIH Publication No. 99-4564. US Govt Print Office, Washington, DC: http://cancer.gov/atlasplus/new.html.Cited 24 August 2006
Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66:1191–308
Donaldson MS (2004) Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr J 3:19
Ferlay J, Bray F, Pisani P et al (2002) GLOBOCAN: Cancer incidence, mortality and prevalence worldwide IARC CancerBase No. 5. version 2.0, IARC-Press, Lyon, http://www-dep.iarc.fr. Cited 24 August 2006
Freedman DM, Dosemeci M, McGlynn K et al (2002) Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study. Occup Environ Med 51:257–262
Garland CF, Garland FC (1980) Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 9:227–231
Garland CF, Garland FC (2006) Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 35:217–220
Garland C, Shekelle RB, Barrett-Connor E et al (1985) Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1:307–309
Garland CF, Comstock GW, Garland FC et al (1989) Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 2:1176–1178
Garland FC, Garland CF, Gorham ED et al (1990) Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med 19:614–622
Garland CF, Garland FC, Gorham ED et al (2003) Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol 13:395–404
Garland CF, Garland FC, Gorham ED et al (2006) The role of vitamin D in cancer prevention. Am J Public Health 96:252–261
Goldzieher JW, Zerwekh JE, Castracane VD et al (1999) Single-monthly-dose vitamin D supplementation in elderly patients. Endocr Pract 5:229–232
Gorham ED, Garland FC, Garland CF et al (1990) Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 19:820–824
Gorham ED, Garland CF, Garland FC et al (2005) Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 97:179–194
Grant WB (2002) An estimate of premature cancer mortality in the United States due to inadequate doses of solar ultraviolet-B radiation. Cancer 94:1867–1875
Grant WB (2004) Insufficient sunlight may kill 45,000 Americans each year from internal cancer. J Cos Dermatol 3:176–178
Grant WB (2006) Epidemiology of disease risks in relation to vitamin D insufficiency. Progress Biophys Molec Biol 92:65–79
Grant WB, Garland CF (2004) A critical review of studies on vitamin D in relation to colorectal cancer. Nutr Cancer 48:115–123
Grant WB, Garland CF (2006) The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res 26:2687–2699
Grant WB, Holick MF (2005) Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev 10:94–111
Grant WB, Garland CF, Holick, MF et al (2005) Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United States. Photochem Photobiol 81:1276–1286
Halliday GM (2005) Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis. Mutat Res 571:107–120
Halliday GM, Agar NS, Barnetson RS et al (2005) UVA fingerprint mutations in human skin cancer. Photochem Photobiol 81:3–8
Hanchette CL, Schwartz GG (1992) Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer 70:2861–2869
Heaney RP (2003) Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 78:912–919
Hill AB (1965) The environment and disease: Association or causation? Proc R Soc Med 58:295–300
Holick MF (2004a) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S–1688S
Holick MF (2004b) Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362–371
Holick MF (2006) High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81:353–373
Hughes AM, Armstrong BK, Vajdic CM et al (2004) Sun exposure may protect against non-Hodgkin lymphoma: a case-control study. Int J Cancer 112:865–871
Institute of Medicine, National Academy of Sciences (1997) Dietary reference intakes for calcium, phosphorous, magnesium, vitamin D, and fluoride. National Academy Press, Washington, DC
John EM, Schwartz GG, Koo J et al (2005) Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer. Cancer Res 65:5470–5479
Kennedy C, Bajdik CD, Willemze R et al (2003) The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer. J Invest Dermatol 120:1087–1093
Krishnan AV, Peehl DM, Feldman D et al (2003) The role of vitamin D in prostate cancer. Recent Results Cancer Res 164:205–221
Laaksi IT, Ruohola JP, Ylikomi TJ et al (2006) Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men. Eur J Clin Nutr 60:1035–1038
Lamprecht SA, Lipkin M (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer 3:601–614
Leffell DJ, Brash DE (1996) Sunlight and skin cancer. Sci Am 275:52–53, 56–59
Lefkowitz ES, Garland CF (1994) Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol 23:1133–1136
Lips P (1987) Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr 46:1005–1010
Matsuoka LY, Wortsman J, Hanifan N et al (1988) Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D. A preliminary study. Arch Dermatol 124:1802–1804
McKenna MJ (1992) Differences in vitamin D status between countries in young adults and the elderly. Am J Med 93:69–77
Millen AE, Tucker MA, Hartge P et al (2004) Diet and melanoma in a case-control study. Cancer Epidemiol Biomarkers Prev 13:1042–1051
Moan J, Porojnicu AC, Robsahm, Dahlback A et al. (2005) Solar radiation, vitamin D and survival rate of colon cancer in Norway. J Photochem Photobiol B 78:189–193
Mosekilde L (2005) Vitamin D and the elderly. Clin Endocrinol (Oxf) 62:265–281
Nakagawa K, Kawaura A, Kato S et al (2005) 1 alpha, 25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer. Carcinogenesis 26:429–440
National Cancer Institute (2006) Surveillance Research Program, SEER*Stat software (seer.cancer.gov/seerstat) version 6.1.4
Natri AM, Salo P, Vikstedt T et al (2006) Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement. J Nutr 136:123–127
Nutrition Monitoring Div., Human Nutrition Information Service, U.S. Dept. of Agriculture (1985) Food and nutrient intakes: individuals in four regions, year 1977–78. Report No. I–3. U.S. Dept. of Agriculture, Hyattsville, MD
Ovesen L, Andersen R, Jakobsen J et al (2003) Geographical differences in vitamin D status, with particular reference to European countries. Proc Nutr Soc 62:813–821
Palmer HG, Gonzalez-Sancho JM et al (2001) Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 154:369–387
Peterlik M, Cross HS (2005) Vitamin D and calcium insufficiencies predispose for multiple chronic diseases. Eur J Clin Invest 35:290–304
Plotnikoff GA, Quigley JM (2003) Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 78:1463–1470
Porojnicu AC, Robsahm TE, Ree AH et al (2005) Season of diagnosis is a prognostic factor in Hodgkin’s lymphoma: a possible role of sun-induced vitamin D. Br J Cancer 93:571–574
Punnonen R, Gillepsy M, Hahl M et al (1988) Serum 25-OHD, vitamin A and vitamin E concentrations in healthy Finnish and Floridian women. Int J Vitam Nutr Res 58:37–39
Riffenburgh RH (1999) Statistics in medicine. Academic Press, San Diego
Rucker D, Allan JA, Fick GH, Hanley DA (2002) Vitamin D insufficiency in a population of healthy western Canadians. CMAJ 166:1517–1524
Robsahm TE, Tretli S, Dahlback A, Moan J (2004) Vitamin D3 from sunlight may improve the prognosis of breast-, colon-and prostate cancer (Norway). Cancer Causes Control 15:149–158
Schwartz GG (2005) Vitamin D and the epidemiology of prostate cancer. Semin Dial 18:276–289
Schwarz T (2005) Mechanisms of UV-induced immunosuppression. Keio J Med 54:165–171
Slattery ML, Sweeney C, Murtaugh M et al (2006) Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer. Int J Cancer 118:3140–3146
Smedby KE, Hjalgrim H, Melbye M et al (2005) Ultraviolet radiation exposure and risk of malignant lymphomas. J Natl Cancer Inst 97:199–209
Tangpricha V, Koutkia P, Rieke SM et al (2003) Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Am J Clin Nutr 77:1478–1483
Ullrich SE (2005) Mechanisms underlying UV-induced immune suppression. Mutat Res 571:185–205
Van den Bemd GJ, Chang GT (2002) Vitamin D and vitamin D analogs in cancer treatment. Curr Drug Targets 3:85–94
Vieth R (1999) Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69:842–856
Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 67:373–378
Whiting SJ, Calvo MS (2005a) Dietary recommendations for vitamin D: a critical need for functional end points to establish an estimated average requirement. J Nutr 135:304–309
Whiting SJ, Calvo MS (2005b) Dietary recommendations to meet both endocrine and autocrine needs of Vitamin D. J Steroid Biochem Mol Biol 97:7–12
Wolpowitz D, Gilchrest BA (2006) The vitamin D questions: how much do you need and how should you get it? J Am Acad Dermatol 54:301–317
Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M (2001) Extrarenal expression of 25-hydroxyvitamin d(3)-1 alphahydroxylase. J Clin Endocrinol Metab 86:888–894
Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Giovannucci E, Christiani DC (2005) Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev 14:2303–2309
Zittermann A, Schleithoff SS, Koerfer R et al (2005) Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 94:483–492
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Grant, W.B., Garland, C.F., Gorham, E.D. (2007). An Estimate of Cancer Mortality Rate Reductions in Europe and the US with 1,000 IU of Oral Vitamin D Per Day. In: Senn, HJ., Kapp, U. (eds) Cancer Prevention. Recent Results in Cancer Research, vol 174. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37696-5_20
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DOI: https://doi.org/10.1007/978-3-540-37696-5_20
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