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TRP Channels of the Pancreatic Beta Cell

  • Chapter
Transient Receptor Potential (TRP) Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 179))

Abstract

Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and may be essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hormone secretion and glucose homeostasis (reviewed by Houamed et al. 2004). This chapter focuses on transient receptor potential (TRP)-related channels found within the beta cells of the islet and reviews their roles in both insulin secretion and apoptosis.

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Authors and Affiliations

  1. Department of Medicine—Endocrinology Section, University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA

    D. A. Jacobson & L. H. Philipson

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  1. D. A. Jacobson
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  2. L. H. Philipson
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Editors and Affiliations

  1. Experimentele und Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Gebäude 46, 66421, Homburg, Deutschland

    Veit Flockerzi

  2. Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, België

    Bernd Nilius

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Jacobson, D.A., Philipson, L.H. (2007). TRP Channels of the Pancreatic Beta Cell. In: Flockerzi, V., Nilius, B. (eds) Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34891-7_24

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