Skip to main content

Diseases of the Lips and Mouth

  • Chapter
Braun-Falco’s Dermatology

Abstract

Although the oral mucosa is derived from the same embryonic tissue as the skin — the ectoderm — it differs in many ways. Structurally, the oral mucosa undergoes a different type of keratinization; in some sites, parakeratosis is normal, while in most others no granular layer is seen. The epithelial surface is capable of regenerating very rapidly, replacing the cells lost through the trauma of eating and drinking. The salivary glands coat the epithelium in saliva, which has a protective role, as well as facilitating the ingestion of food. The subepithelial connective tissue in the gastrointestinal tract, of which the mouth is a part, is known as the lamina propria, not the dermis. In some regions, such as the gingiva and hard palate, the lamina propria is directly attached to bone.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

Books

  • Bork K, Hoede N, Korting GW et al (1996) Disease of the oral mucosa and the lips. Saunders, Philadelphia

    Google Scholar 

  • Scully C, Flint S, Porter SR et al(2004) Oral and maxillofacial disease. Dunitz, London

    Google Scholar 

  • Greenberg M, Glick M. (2003) Burket’s oral medicine: diagnosis and treatment. Decker, Hamilton

    Google Scholar 

  • Regezi JA, Sciubba JJ, Jordan RCK. (2003) Oral pathology: clinical pathologic correlations. Saunders, Philadelphia

    Google Scholar 

  • Neville B, Damm DD, Allen CM, Bouquot (2002) Oral and maxillofacial pathology. Saunders, Philadelphia

    Google Scholar 

  • Sapp JP, Eversole LR, Wysocki GW (2004) Contemporary oral and maxillofacial pathology. Mosby, Saint Louis

    Google Scholar 

Diseases of Lips

  • Carrington PR, Horn TD (2006) Cheilitis glandularis: a clinical marker for both malignancy and/or severe inflammatory disease of the oral cavity. J Am Acad Dermatol 54:336–337

    Article  PubMed  Google Scholar 

  • Hornstein OP (1997) Melkersson-Rosenthal syndrome — a challenge for dermatologists to participate in the field of oral medicine. J Dermatol 24:281–296

    CAS  PubMed  Google Scholar 

  • Howell JB, Freeman RG (2002) The potential peril from caliber-persistent arteries of the lips. J Am Acad Dermatol 46:256–259

    Article  CAS  PubMed  Google Scholar 

  • Kocyigit P, Kocyigit D, Akay BN et al (2006) Calibre persistent labial artery: clinical features and noninvasive radiological diagnosis. Clin Exp Dermatol 31:528–530

    Article  CAS  PubMed  Google Scholar 

  • Sanderson J, Nunes C, Escudier M et al (2005) Oro-facial granulomatosis: Crohn’s disease or a new inflammatory bowel disease? Inflamm Bowel Dis 11:840–846

    Article  PubMed  Google Scholar 

  • Sciubba JJ, Said-Al-Naief N (2003) Orofacial granulomatosis: presentation, pathology and management of 13 cases. J Oral Pathol Med 32:576–585

    Article  PubMed  Google Scholar 

  • Rocha N, Mota F, Horta M et al (2004) Plasma cell cheilitis. J Eur Acad Dermatol Venereol 18:96–98

    Article  CAS  PubMed  Google Scholar 

Diseases of Tongue

  • el-Mofty SK, Swanson PE, Wick MR et al (1993) Eosinophilic ulcer of the oral mucosa. Report of 38 new cases with immunohistochemical observations. Oral Surg Oral Med Oral Pathol 75:716–722

    Article  CAS  PubMed  Google Scholar 

  • Gonzaga HF, Torres EA, Alchorne MM et al (1996) Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol 135:368–370

    Article  CAS  PubMed  Google Scholar 

  • Grushka M, Ching V, Epstein J (2006) Burning mouth syndrome. Adv Otorhinolaryngol 63:278–287

    PubMed  Google Scholar 

  • Isogai Z, Kanzaki T (1993) Pigmented fungiform papillae of the tongue. J Am Acad Dermatol 29:489–490

    Article  CAS  PubMed  Google Scholar 

  • Jainkittivong A, Langlais RP (2005) Geographic tongue: clinical characteristics of 188 cases. J Contemp Dent Pract 6:123–135

    PubMed  Google Scholar 

  • Lehman JS, Bruce AJ, Rogers RS (2006) Atrophic glossitis from vitamin B12 deficiency: a case misdiagnosed as burning mouth disorder. J Periodontol 77:2090–2092

    Article  PubMed  Google Scholar 

  • Pastore L, Lo Muzio L, Serpico R (2007) Atrophic glossitis leading to the diagnosis of celiac disease. N Engl J Med 356:2547

    Article  CAS  PubMed  Google Scholar 

  • Segura S, Romero D, Mascaro JM, Jr. et al (2006) Eosinophilic ulcer of the oral mucosa: another histological simulator of CD30+ lymphoproliferative disorders. Br J Dermatol 155:460–463

    Article  CAS  PubMed  Google Scholar 

  • Whitaker SB, Singh BB (1996) Cause of median rhomboid glossitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81:379–380

    Article  CAS  PubMed  Google Scholar 

  • Zhu JF, Kaminski MJ, Pulitzer DR et al (1996) Psoriasis: pathophysiology and oral manifestations. Oral Dis 2:135–144

    CAS  PubMed  Google Scholar 

  • Zaenglein AL, Chang MW, Meehan SA et al (2002) Extensive Riga-Fede disease of the lip and tongue. J Am Acad Dermatol 47:445–447

    Article  PubMed  Google Scholar 

Diseases of Gingiva

  • Glick M, Muzyka BC, Salkin LM et al (1994) Necrotizing ulcerative periodontitis: a marker for immune deterioration and a predictor for the diagnosis of AIDS. J Periodontol 65:393–397

    CAS  PubMed  Google Scholar 

  • Horning GM, Cohen ME (1995) Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors. J Periodontol 66:990–998

    CAS  PubMed  Google Scholar 

  • Jainkittivong A, Langlais RP (2000) Buccal and palatal exostoses: prevalence and concurrence with tori. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:48–53

    Article  CAS  PubMed  Google Scholar 

  • Khera P, Zirwas MJ, English JC, 3rd (2005) Diffuse gingival enlargement. J Am Acad Dermatol 52:491–499

    Article  PubMed  Google Scholar 

  • Mighell AJ, Robinson PA, Hume WJ (1995) Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients, and literature review. Oral Dis 1:12–19

    CAS  PubMed  Google Scholar 

  • Seah YH (1995) Torus palatinus and torus mandibularis: a review of the literature. Aust Dent J 40:318–321

    Article  CAS  PubMed  Google Scholar 

Diseases of Gums and Palate

  • Mehra S, Li L, Fan CY et al (2005) A novel somatic mutation of the 3betahydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma. Arch Dermatol 141:1263–1267

    Article  PubMed  Google Scholar 

  • Scully C, Eveson J (2004) Sialosis and necrotising sialometaplasia in bulimia; a case report. Int J Oral Maxillofac Surg 33:808–810

    CAS  PubMed  Google Scholar 

  • Diseases of Buccal and Palatal Mucosa (1990) Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet“s Disease. Lancet 335:1078–1080

    Google Scholar 

  • Alpsoy E, Donmez L, Onder M et al (2007) Clinical features and natural course of Behcet’s disease in 661 cases: a multicentre study. Br J Dermatol 157:901–906

    Article  CAS  PubMed  Google Scholar 

  • Balabanova M, Calamia KT, Perniciaro C et al (1999) A study of the cutaneous manifestations of Behcet’s disease in patients from the United States. J Am Acad Dermatol 41:540–545

    CAS  PubMed  Google Scholar 

  • Ballo FS, Camisa C, Allen CM (1989) Pyostomatitis vegetans. Report of a case and review of the literature. J Am Acad Dermatol 21:381–387

    Article  CAS  PubMed  Google Scholar 

  • Bruce A, Rogers RS (2007) New and old therapeutics for oral ulcerations. Arch Dermatol 143:519–523

    Article  PubMed  Google Scholar 

  • Cantatore JL, Klein PA, Lieblich LM (2002) Cutaneous dental sinus tract, a common misdiagnosis: a case report and review of the literature. Cutis 70:264–267

    PubMed  Google Scholar 

  • Enwonwu CO, Falkler WA, Jr., Phillips RS (2006) Noma (cancrum oris). Lancet 368:147–156

    Article  PubMed  Google Scholar 

  • Epstein JB, Zhang L, Rosin M (2002) Advances in the diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc 68:617–621

    PubMed  Google Scholar 

  • Eversole LR (2000) Papillary lesions of the oral cavity: relationship to human papillomaviruses. J Calif Dent Assoc 28:922–927

    CAS  PubMed  Google Scholar 

  • Gorsky M, Epstein JB (2002) The effect of retinoids on premalignant oral lesions: focus on topical therapy. Cancer 95:1258–1264

    Article  CAS  PubMed  Google Scholar 

  • Imbery TA, Edwards PA (1996) Necrotizing sialometaplasia: literature review and case reports. J Am Dent Assoc 127:1087–1092

    CAS  PubMed  Google Scholar 

  • LaPorta VN, Nikitakis NG, Sindler AJ et al (2005) Minocycline-associated intra-oral soft-tissue pigmentation: clinicopathologic correlations and review. J Clin Periodontol 32:119–122

    Article  PubMed  Google Scholar 

  • Letsinger JA, McCarty MA, Jorizzo JL (2005) Complex aphthosis: a large case series with evaluation algorithm and therapeutic ladder from topicals to thalidomide. J Am Acad Dermatol 52:500–508

    Article  PubMed  Google Scholar 

  • Martin JL (1992) Leukoedema: a review of the literature. J Natl Med Assoc 84:938–940

    CAS  PubMed  Google Scholar 

  • Mehra S, Li L, Fan CY et al (2005) A novel somatic mutation of the 3betahydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma. Arch Dermatol 141:1263–1267

    Article  PubMed  Google Scholar 

  • Miller CS, Johnstone BM (2001) Human papillomavirus as a risk factor for oral squamous cell carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:622–635

    Article  CAS  PubMed  Google Scholar 

  • Porter SR, Scully C (2006) Oral malodour (halitosis). Br Med J 333:632–635

    Article  CAS  Google Scholar 

  • Ruiz-Roca JA, Berini-Aytes L, Gay-Escoda C (2005) Pyostomatitis vegetans. Report of two cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:447–454

    Article  PubMed  Google Scholar 

  • Sakane T, Takeno M, Suzuki N et al (1999) Behcet’s disease. N Engl J Med 341:1284–1291

    Article  CAS  PubMed  Google Scholar 

  • Scully C, Eveson J (2004) Sialosis and necrotising sialometaplasia in bulimia; a case report. Int J Oral Maxillofac Surg 33:808–810

    CAS  PubMed  Google Scholar 

  • Scully C (2006) Clinical practice. Aphthous ulceration. N Engl J Med 355:165–172

    Article  CAS  PubMed  Google Scholar 

  • Thornhill MH, Baccaglini L, Theaker E et al (2007) A randomized, doubleblind, placebo-controlled trial of pentoxifylline for the treatment of recurrent aphthous stomatitis. Arch Dermatol 143:463–470

    Article  CAS  PubMed  Google Scholar 

  • Torgerson RR, Davis MD, Bruce AJ et al (2007) Contact allergy in oral disease. J Am Acad Dermatol 57:315–321

    Article  PubMed  Google Scholar 

  • Yarom N, Hirshberg A, Buchner A (2007) Solitary and multifocal oral melanoacanthoma. Int J Dermatol 46:1232–1236

    PubMed  Google Scholar 

Classic Papers

  • Abrams AM, Melrose RJ, Howell FV (1973) Necrotizing sialometaplasia: a disease simulating malignancy. Cancer 32:130–135

    Article  CAS  PubMed  Google Scholar 

  • Adamantiades B (1931) Sur un cas d’iritis hypopyon récidivant. Ann Oculist 168:271–278

    Google Scholar 

  • Archard HO, Heck JW, Stanley HR (1965) Focal epithelial hyperplasia: an unusual mucosal lesion found in Indian children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 20:201–206

    CAS  Google Scholar 

  • Arnemann J (1787) Commentatio de aphthis. Vanderhoeck et Ruprecht, Gottingae

    Google Scholar 

  • Bednaŕ A (1850-1853) Die Krankheiten der Neugebornen und Säuglinge vom klinischen und pathologisch-anatomische Standpunkten. 4 vol. Gerold, Wien, vol 1:104

    Google Scholar 

  • Behçet H (1937) über rezidivierende, aphthöse, durch einen Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 105:1152–1157

    Google Scholar 

  • Brocq L, Pautrier LM (1914) Glossite losangique médiane de la face dorsale de la langue. Ann Dermatol Syphiligr (Paris) 5:1–18

    Google Scholar 

  • Cannon AB (1935) White sponge nevus of the mucosa (naevus mucosus albus mucosae). Arch Dermatol Syphilol 31:365–370

    Google Scholar 

  • Chase MW (1946) Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 61:257

    CAS  Google Scholar 

  • Cooke BED, Armitage P (1960) Recurrent Mikulicz’s aphthae treatment with topical hydrocortisone hemisuccinate sodium. Double-blind controlled clinical trial. Br Med J I:764–766

    Article  Google Scholar 

  • Fede F (1891) Della produzione sottolinguale o malattia di Riga. Atto Congresso italiano di pediatria 1890. Napoli, p 251

    Google Scholar 

  • Fordyce J (1896) A peculiar affection of the mucous membrane of the lips and oral cavity. J Cutan Genito Urin Dis 14:413–419

    Google Scholar 

  • Gruetz O, (1928) Ueber Pseudoleukokeratose der Mundschleimhaut. Dermatol Wochenschr 87:1075–1078

    Google Scholar 

  • Hunter W (1900) Further observations on pernicious anaemia (seven cases): a chronic infective disease; its relation to infection from the mouth and stomach; suggested serum treatment. Lancet I:221–224

    Article  Google Scholar 

  • Leonard TMR (1905) Ankylosomiasis or uncinariasis. JAMA 45:588–594

    Google Scholar 

  • Levinstein O (1912) Ueber eine neue „pathologische Tonsille“ des menschlichen Schlundes, die „Tonsilla linguae lateralis“ und ihre Erkrankung der Angina. Arch Laryngol 26:687

    Google Scholar 

  • Manganotti G (1934) Cheilitis abrasiva praecancerosa. Arch Ital Dermatol 10:25

    Google Scholar 

  • McCarthy FP (1949) Pyostomatitis vegetans: report of three cases. Arch Dermatol Syphilol 60:750–764

    CAS  Google Scholar 

  • Melkersson E (1928) Ett fall av recidiverande facialispares i samband med angioneurotisk ödem. Hygiea 90:737–741

    Google Scholar 

  • Miescher G (1945) über essentielle granulomatöse Makrocheilie (Cheilitis granulomatosa). Dermatologica 91:57–85

    Article  Google Scholar 

  • Miko T, Adler P, Endes P (1980) Simulated cancer of the lower lip attributed to a „caliber persistent“ artery. J Oral Pathol 9:137–144

    Article  CAS  PubMed  Google Scholar 

  • von Mikulicz-Radecki J (1888) Ueber eine eigenartige symmetrische Erkrankung der Thränen-und Mundspeicheldrüsen. Beiträge zur Chirurgie: Festschrift gewidmet Theodor Billroth von seinen dankbaren Schülern zur Feier des vollendeten fünfzigsten Semesters seines Akademischen Wirkens in Wien. Enke, Stuttgart, p 610

    Google Scholar 

  • Möller JOL (1851) Klinische Bemerkungen über einige weniger bekannte Krankheiten der Zunge. Dtsch Klin 3:273–275

    Google Scholar 

  • Plaut HK (1894) Studien zur bacteriellen Diagnostik der Diphtherie und der Anginen. Deutsch Med Wochenschr 20:920–923

    Article  Google Scholar 

  • Riga A (1881) Di una malattia della prima infanzia, Probabilmente non trattata, di movimenti patologici. Napoli

    Google Scholar 

  • Rosenthal C (1931) Klinisch-erbbiologischer Beitrag zur Konstitutionspathologie. Gemeinsames Auftreten von (rezidivirender familiärer) Fazialislähmung, angioneurotischem Gesichtödem und Lingua plicata in Arthritismus-Familien. Z Neurol Psychiatr 131:475–500

    Article  Google Scholar 

  • von Sallmann L, Paton D (1960) Hereditary benign intraepithelial dyskeratosis. I. Ocular manifestations. Arch Ophthalmol 63:421–429

    Google Scholar 

  • Sandstead HR, Lowe JW (1953) Leukoedema and keratosis in relation to leukoplakia of the buccal mucosa in man. J Natl Cancer Inst 14:423–437

    CAS  PubMed  Google Scholar 

  • Schwimmer E (1877) Die idiopathischen Schleimhautplaques der Mundhöhle; (Leukoplakia buccalis). Arch Dermatol Syph (German) 9:511–570

    Google Scholar 

  • Sutton RL (1909) Cheilitis glandularis apostematosa (with case report). J Cutan Dis 27: 151–154

    Google Scholar 

  • Shafer WG (1971) Verruciform xanthoma. Oral Surg Med Oral Pathol 31: 784–789

    Article  CAS  Google Scholar 

  • Shapiro L, Juhlin EA (1970) Eosinophilic ulcer of the tongue. Dermatologica 140:242–250

    Article  CAS  PubMed  Google Scholar 

  • Sutton RL (1911) Periadenitis mucosa necrotica recurrens. J Cutan Dis 29: 65–71

    Google Scholar 

  • Takahara S, Muyamoto H (1948) Clinical and experimental studies on the odotogenous progressive necrotic ostitis due to lack of blood catalase. J Otorhinol Soc Jpn 51:163–164 (in Japanese)

    Google Scholar 

  • Vincent JH (1896) Sur l’étiologie et sur les lésions anatomo-pathologiques de la pourriture d’hôpital. Ann Inst Pasteur 10:488–510

    Google Scholar 

  • von Volkmann R (1870) Einige Fälle von Cheilitis glandularis apostematosa (Myxadenitis labialis). Virchows Arch Pathol Anat 50:142–144

    Article  Google Scholar 

  • Witkop CJ Jr, Shankle CH, Graham JB et al (1960) Hereditary benign intraepithelial dyskeratosis. II. Oral manifestations and hereditary transmission. Arch Pathol 70:696–711

    PubMed  Google Scholar 

  • Witkop CJ Jr, White JG, King RA et al (1979) Hereditary mucoepithelial dysplasia: a disease apparently of desmosome and gap junction formation. Am J Hum Genet 31:414–427

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Bork, K. (2009). Diseases of the Lips and Mouth. In: Burgdorf, W.H., Plewig, G., Wolff, H.H., Landthaler, M., Braun-Falco, O. (eds) Braun-Falco’s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29316-3_71

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-29316-3_71

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-29312-5

  • Online ISBN: 978-3-540-29316-3

Publish with us

Policies and ethics