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Cutaneous Adverse Drug Reactions

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Braun-Falco’s Dermatology

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Abstract

Epidemiology. Maculopapular exanthems are the most common adverse drug reactions, along with urticaria. Almost every medication on the market has caused at least one maculopapular exanthem.

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Bibliography

Books

  • Bork K (1988) Cutaneous side effects of drugs. Saunders, Philadelphia

    Google Scholar 

  • Bruinsma W (2000) Side effects in dermatology, 7th ed. Intermed Medical Publishers, Amsterdam

    Google Scholar 

  • Litt JZ (2004) Litt’s pocketbook of drug eruptions and interactions. 3rd ed. Parthenon, Boca Raton

    Google Scholar 

  • Litt JZ (2007) Litts drug eruption reference manual including drug interactions. 13th ed. Informa Healthcare, New York

    Google Scholar 

  • Zürcher K, Krebs A (1992) Cutaneous drug reactions, 2nd ed. Karger, Basel

    Google Scholar 

Papers

  • Agostoni A, Cicardi M (2001) Drug-induced angioedema without urticaria. Drug Safety 24:599–606

    Article  CAS  PubMed  Google Scholar 

  • Alley E, Green R, Schuchter L (2002) Cutaneous toxicities of cancer therapy. Curr Opin Oncol 14:212–216

    Article  CAS  PubMed  Google Scholar 

  • Autier J, Escudier B, Wechsler J et al (2008) Prospective study of the cutaneous adverse effects of sorafenib, a novel multikinase inhibitor. Arch Dermatol 144:886–892

    Article  CAS  PubMed  Google Scholar 

  • Baack BR, Burgdorf WH (1991) Chemotherapy-induced acral erythema. J Am Acad Dermatol 24:457–461

    Article  CAS  PubMed  Google Scholar 

  • Bastuji-Garin S, Joly P, Picard-Dahan C et al (1993) Drugs associated with bullous pemphigoid. A case-control study. Arch Dermatol 132:272–276

    Article  Google Scholar 

  • Bhattacharjee P, Glusac EJ (2004) Early histopathologic changes in purple glove syndrome. J Cutan Pathol 31:513–515

    Article  PubMed  Google Scholar 

  • Budach W, Bolke E, Homey B (2007) Severe cutaneous reaction during radiation therapy with concurrent cetuximab. N Engl J Med 357:514–515

    Article  CAS  PubMed  Google Scholar 

  • Callen JP (2001) Drug-induced cutaneous lupus erythematosus, a distinct syndrome that is frequently unrecognized. J Am Acad Dermatol 45:315–316

    Article  CAS  PubMed  Google Scholar 

  • Carroll MC, Yueng-Yue KA, Esterly NB et al (2001) Drug-induced hypersensitivity syndrome in pediatric patients. Pediatrics 108:485–492

    Article  CAS  PubMed  Google Scholar 

  • Comp PC (1993) Coumarin-induced skin necrosis. Incidence, mechanisms, management and avoidance. Drug Safety 8:128–135

    Article  CAS  PubMed  Google Scholar 

  • Dalmau J, Pimentel CL, Puig L et al (2005) Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa. J Am Acad Dermatol 53:62–66

    Article  PubMed  Google Scholar 

  • DeWitt CA, Siroy AE, Stone SP (2007) Acneiform eruptions associated with epidermal growth factor receptor-targeted chemotherapy. J Am Acad Dermatol 56:500–505

    Article  PubMed  Google Scholar 

  • Goldfeder KL, Levin JM, Katz KA et al (2007) Ultraviolet recall reaction after total body irradiation, etoposide, and methotrexate therapy. J Am Acad Dermatol 56:494–499

    Article  PubMed  Google Scholar 

  • Grattan CEH (2004) Aspirin sensitivity and urticaria. Clin Exp Dermatol 28:123–127

    Article  Google Scholar 

  • Heidary N, Naik H, Burgin S (2008) Chemotherapeutic agents and the skin: An update. J Am Acad Dermatol 58:545–570

    Article  PubMed  Google Scholar 

  • Justiniano H, Berlingeri-Ramos AC, Sanchez JL (2008) Pattern analysis of drug-induced skin diseases. Am J Dermatopathol 30:352–369

    Article  PubMed  Google Scholar 

  • Le Goff P, Saraux A (1999) Drug-induced lupus. Rev Rhum Engl Ed 66:40–45

    Google Scholar 

  • Lotti T, Ghersetich I, Comacchi C et al (1998) Cutaneous small-vessel vasculitis. J Am Acad Dermatol 39:667–687

    Article  CAS  PubMed  Google Scholar 

  • Mahhob A, Haroon TS (1998) Drugs causing fixed eruptions: a study of 450 cases. Int J Dermatol 37:833–838

    Article  Google Scholar 

  • Nettis E, Marcandrea M, Di Maggio G et al (2001) Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. Immunopharmacol Immunotoxicol 23:585–595

    Article  CAS  PubMed  Google Scholar 

  • Palareti G, Leali N, Coccheri S et al (1996) Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Lancet 348:423–428

    Article  CAS  PubMed  Google Scholar 

  • Patel DD, Goldberg RM (2006) Cetuximab-associated infusion reactions: pathology and management. Oncology 20:1373–1382

    PubMed  Google Scholar 

  • Payne AS, James WD, Weiss RB (2006) Dermatologic toxicity of chemotherapeutic agents. Semin Oncol 33:86–97

    Article  CAS  PubMed  Google Scholar 

  • Pichichero ME, Casey JR (2007) Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis. Otolaryngol Head Neck Surg 136:340–347

    Article  PubMed  Google Scholar 

  • Piraccini BM, Tosti A (1999) Drug-induced nail disorders: incidence, management and prognosis. Drug Safety 21:187–201

    Article  CAS  PubMed  Google Scholar 

  • Remlinger KA (2003) Cutaneous reactions to chemotherapy drugs: the art of consultation. Arch Dermatol 139:77–81

    Article  PubMed  Google Scholar 

  • Renn CN, Straff W, Dorfmüller A et al (2003) Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity. Br J Dermatol 147:1166–1167

    Article  Google Scholar 

  • Rubin RL (1999) Etiology and mechanisms of drug-induced lupus. Curr Opin Rheumatol 11:357–363

    Article  CAS  PubMed  Google Scholar 

  • Shiohara T, Mizukawa Y, Teraki Y (2002) Pathophysiology of fixed drug eruption: the role of skin-resident T cells. Curr Opin Allergy Clin Immunol 2:317–323

    Article  PubMed  Google Scholar 

  • Shipley D, Ormerod AD (2001) Drug-induced urticaria. Recognition and treatment. Am J Clin Dermatol 2:151–158

    Article  CAS  PubMed  Google Scholar 

  • Susser WS, Whitaker-Worth DL, Grant-Kels JM (1999) Mucocutaneous reactions to chemotherapy. J Am Acad Dermatol 40:367–398

    Article  CAS  PubMed  Google Scholar 

  • Tan EK, Grattan CE (2004) Drug-induced urticaria. Expert Opin Drug Saf 3:471–484

    Article  CAS  PubMed  Google Scholar 

  • Thorisdottir K, Tomecki KJ, Bergfeld WF et al (1993) Neutrophilic eccrine hidradenitis. J Am Acad Dermatol 28:775–777

    Article  CAS  PubMed  Google Scholar 

  • Tosti A, Misciali C, Piraccine BM et al (1994) Drug-induced hair loss and hair growth. Incidence, management and avoidance. Drug Safety 10: 310–317

    Article  CAS  Google Scholar 

  • Tosti A, Pazzaglia M (2007) Drug reactions affecting hair: diagnosis. Dermatol Clin 25:223–231

    Article  CAS  PubMed  Google Scholar 

  • Warner KK, Visconti JA, Tschampel MM (2000) Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema. Ann Pharmacother 34:526–528

    Article  CAS  PubMed  Google Scholar 

  • de Weck AL, Gamboa PM, Esparza R et al (2006) Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Curr Pharm Des 12:3347–3358

    Article  PubMed  Google Scholar 

  • Wong BB, Keith PK, Waserman S (2006) Clinical history as a predictor of penicillin skin test outcome. Ann Allergy Asthma Immunol 97:169–174

    Article  PubMed  Google Scholar 

  • Yawalkar N, Pichler WJ (2001) Pathogenesis of drug-induced exanthema. Int Arch Allergy Immunol 124:336–338

    Article  CAS  PubMed  Google Scholar 

Cutaneous Signs of Drug Abuse

  • Binswanger IA, Kral AH, Bluthenthal RN et al (2000) High prevalence of abscesses and cellulitis among community-recruited injection drug users in San Francisco. Clin Infect Dis 30:579–581

    Article  CAS  PubMed  Google Scholar 

  • Brewer JD, Meves A, Bostwick JM et al (2008) Cocaine abuse: Dermatologic manifestations and therapeutic approaches. J Am Acad Dermatol 59:483–487

    Article  PubMed  Google Scholar 

  • Burnett JW (1992) Drug abuse. Cutis 49:307–308

    CAS  PubMed  Google Scholar 

  • Del Giudice P (2004) Cutaneous complications of intravenous drug abuse. Br J Dermatol 150:1–10

    Article  PubMed  Google Scholar 

  • Del Giudice P, Durant J, Dellamonica P (2006) Hand edema and acrocyanosis: puffy hand syndrome. Arch Dermatol 142:1084–1085

    Article  PubMed  Google Scholar 

  • Feuillet L, Mallet S, Spadari M (2006) Twin girls with neurocutaneous symptoms caused by mothball intoxication. N Engl J Med 355:423–424

    Article  CAS  PubMed  Google Scholar 

  • Gordon RJ, Lowy FD (2005) Bacterial infections in drug users. N Engl J Med 353:1945–1954

    Article  CAS  PubMed  Google Scholar 

  • Kimura AC, Higa JI, Levin RM et al (2004) Outbreak of necrotizing fasciitis due to Clostridium sordellii among black-tar heroin users. Clin Infect Dis 38:e87–91

    Article  PubMed  Google Scholar 

  • Lu LK, High WA (2007) Acute generalized exanthematous pustulosis caused by illicit street drugs? Arch Dermatol 143:430–431

    Article  PubMed  Google Scholar 

  • Passaro DJ, Werner SB, McGee J, Mac Kenzie WR, Vugia DJ. (1998) Wound botulism associated with black tar heroin among injecting drug users. JAMA 279:859–863

    Article  CAS  PubMed  Google Scholar 

  • Wiesner O, Russell KA, Lee AS et al (2004) Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. Arthritis Rheum 50:2954–2965

    Article  CAS  PubMed  Google Scholar 

  • Wollina U, Kammler HJ, Hesselbarth N et al (1998) Ecstasy pimples — a new facial dermatosis. Dermatology 197:171–173

    Article  CAS  PubMed  Google Scholar 

Classic Papers

  • Andersen KE, Hjorth N, Menne T (1984) The baboon syndrome: Systemicallyinduced allergic contact dermatitis. Contact Dermatitis 10:97–100

    Article  CAS  PubMed  Google Scholar 

  • Burgdorf WHC, Gilmore WA, Ganick RG (1982) Peculiar acral erythema secondary to high-dose chemotherapy for acute myelogenous leukemia. Ann Intern Med 97:61–62

    CAS  PubMed  Google Scholar 

  • Freudenthal W (1924) Lokales embolisches Bismogenol-Exanthem. Arch Dermatol Syph (German) 147:155–160

    Article  Google Scholar 

  • Hoigné R, Schoch K (1959) Anaphylaktischer Schock und akute, nicht allergische Reaktionen nach Procain-Penicillin. Schweiz Med Wochenschr 89:1350–1356

    PubMed  Google Scholar 

  • Nicolau S (1925) Dermate livédoide et grangréneuse de la fesse, consécutive au injections intra-musculaires dans la syphilis. A propos d’un cas d’embolie artérielle bismuthique. Ann Mal Vénér 20:321–329

    Google Scholar 

  • Zuehlke RL (1974) Erythematous eruption of the palms and soles associated with mitotane therapy. Dermatologica 148:90–92

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Hautklinik, Johannes-Gutenberg-Universität, Langenbeckstraße 1, 55131, Mainz, Germany

    Konrad Bork

Authors
  1. Konrad Bork
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Editor information

Editors and Affiliations

  1. Traubinger Straße 45A, 82327, Tutzing, Germany

    Walter H.C. Burgdorf MD  & Otto Braun-Falco  & 

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstraße 9-11, 80337, München, Germany

    Gerd Plewig F.R.C.P.

  3. Thiewall 11, 31840, Hess.-Oldendorf/Lachem, Germany

    Helmut H. Wolff

  4. Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93042, Regensburg, Germany

    Michael Landthaler

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Bork, K. (2009). Cutaneous Adverse Drug Reactions. In: Burgdorf, W.H., Plewig, G., Wolff, H.H., Landthaler, M., Braun-Falco, O. (eds) Braun-Falco’s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29316-3_33

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  • DOI: https://doi.org/10.1007/978-3-540-29316-3_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-29312-5

  • Online ISBN: 978-3-540-29316-3

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