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Microenvironment Influences Cancer Cell Mechanics from Tumor Growth to Metastasis

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Biomechanics in Oncology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1092))

Abstract

The microenvironment in a solid tumor includes a multitude of cell types, matrix proteins, and growth factors that profoundly influence cancer cell mechanics by providing both physical and chemical stimulation. This tumor microenvironment, which is both dynamic and heterogeneous in nature, plays a critical role in cancer progression from the growth of the primary tumor to the development of metastatic and drug-resistant tumors. This chapter provides an overview of the biophysical tools used to study cancer cell mechanics and mechanical changes in the tumor microenvironment at different stages of cancer progression, including growth of the primary tumor, local invasion, and metastasis. Quantitative single cell biophysical analysis of intracellular mechanics, cell traction forces, and cell motility can easily be combined with analysis of critical cell fate processes, including adhesion, proliferation, and drug resistance, to determine how changes in mechanics contribute to cancer progression. This biophysical approach can be used to systematically investigate the parameters in the tumor that control cancer cell interactions with the stroma and to identify specific conditions that induce tumor-promoting behavior, along with strategies for inhibiting these conditions to treat cancer. Increased understanding of the underlying biophysical mechanisms that drive cancer progression may provide insight into novel therapeutic approaches in the fight against cancer.

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Authors and Affiliations

  1. Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA

    Deepraj Ghosh & Michelle R. Dawson

  2. Center for Biomedical Engineering, Brown University, Providence, RI, USA

    Michelle R. Dawson

  3. School of Engineering, Brown University, Providence, RI, USA

    Michelle R. Dawson

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  1. Deepraj Ghosh
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  2. Michelle R. Dawson
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Correspondence to Michelle R. Dawson .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA

    Cheng Dong

  2. Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Nastaran Zahir

  3. Department of Chemical and Biomolecular Engineering Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA

    Konstantinos Konstantopoulos

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Ghosh, D., Dawson, M.R. (2018). Microenvironment Influences Cancer Cell Mechanics from Tumor Growth to Metastasis. In: Dong, C., Zahir, N., Konstantopoulos, K. (eds) Biomechanics in Oncology. Advances in Experimental Medicine and Biology, vol 1092. Springer, Cham. https://doi.org/10.1007/978-3-319-95294-9_5

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